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New processing method of biodegradable stent

A processing method and biological technology, applied in the processing field of biodegradable stents, can solve problems such as no obvious improvement in expansion and fracture, large elastic retraction of stents, and inability to significantly improve radial support force, etc.

Inactive Publication Date: 2012-03-14
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stent prepared by this method has no obvious improvement in solving the large elastic recoil and expansion fracture of the stent
Moreover, the fibers in this patent document can only be oriented along the circumferential direction and the axial direction, but cannot be oriented along the radial direction, so that the radial support force of the stent still cannot be significantly improved

Method used

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  • New processing method of biodegradable stent
  • New processing method of biodegradable stent
  • New processing method of biodegradable stent

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0054] The preparation of the blank type 2 mentioned in the above-mentioned steps 1. can be selected from any of the following methods, but is not limited to the following methods:

[0055] The biodegradable material is first processed into a tube by extrusion or injection molding, and then the tube is cut into a hollowed-out stent blank by laser2;

[0056] Prepare the biodegradable material into silk, and then weave the silk into mesh stent blank form 2;

[0057] Preparing a biodegradable material solution into a thin film by a precipitation method, then winding the film into a filament, and then weaving the filament into a stent blank 2; or

[0058] The biodegradable material is directly injected into the scaffold blank 2 in the injection mold.

[0059] The geometric dimensions of the stent blank mentioned in the above step ① need to be strictly controlled to ensure that the geometric dimensions of the final stent can meet the requirements of outer diameter and wall thickne...

example 1

[0071] The material of the stent body selected in Example 1 is polylactic acid, a biodegradable polymer material. The polylactic acid is extruded into a pipe with an outer diameter of 2.0 mm and a wall thickness of 0.3 mm. The tube is cut into such as by laser cutting method image 3 In the stent blank 2 shown, the outer diameter of the stent blank 2 is 2.0 mm, and the wall thickness is 0.3 mm. Press and grip this stent blank 2 on an elastic tubing, such as polyamide tubing or polyether block amide tubing (the outer diameter of the elastic tubing is 1.0 mm), to form a stent blank 2 in a crimped state with an outer diameter of only 1.6 mm . Put the crimped stent blank 2 and elastic tubing into a stainless steel casing with an inner diameter of 3 mm, and the whole stent blank processing system is as follows: figure 1 shown. One end of the elastic tube is closed, and the other end of the elastic tube is connected to the filling device 4 through a high-pressure gas path, and t...

example 2

[0075] The material of the stent body selected in Example 2 is a biodegradable polymer material polylactic acid-glycolic acid copolymer. First, by injection molding, polylactic acid-glycolic acid copolymer is injection-molded into a mesh stent blank 2 with an outer diameter of 1.0 mm and a wall thickness of 0.2 mm. Put the stent blank 2 over an elastic tubing (such as latex tubing). Then, put the stent blank 2 and the latex tube into a stainless steel casing with an inner diameter of 2.5 mm, wherein one end of the latex tube is closed, and the other end of the latex tube is connected to the filling device 4 through a high-pressure air circuit. Then, the entire stent blank processing system (including the stent blank 2, the latex tube and the stainless steel casing) was heated to 40° C., and at the same time, the latex tube was filled with high-pressure air with a pressure of 400 Psi. Thus, while the latex tube is expanding, the stent blank 2 is expanded. The stent blank 2 ex...

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Abstract

The invention provides a new processing method of a biodegradable stent. The processing method comprises the following steps: (1) preparing a parison of the biodegradable stent from a biodegradable material; and (2) blow-molding the parison so that a material in each wave pole of the parison is highly oriented along the forced direction at the wave pole, and finally obtaining the biodegradable stent. By adopting the processing method, the strength and toughness of the biodegradable stent can be effectively improved.

Description

technical field [0001] The invention relates to a processing method of a biodegradable bracket for medical use. Background technique [0002] Medical devices for coronary intervention have experienced two major breakthroughs, from balloon-expandable catheters to permanent bare-metal stents, and then to drug-eluting permanent metal stents. The implantation of drug-eluting permanent metal stents can effectively avoid the complications of acute vascular occlusion, and can also significantly reduce the incidence of restenosis after percutaneous coronary intervention (PCI). However, drug-eluting permanent metal stents will permanently remain in the human body after completing their tasks, so they will weaken MRI or CT images of coronary arteries, interfere with surgical revascularization, hinder the formation of collateral circulation, and inhibit positive vascular remodeling and other defects. Based on such problems, biodegradable scaffolds have attracted more and more attenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C49/00A61F2/82A61F2/90
CPCA61L31/148A61F2/915B29C49/04B29L2031/7542
Inventor 孟娟陈树国石秀凤陈宝爱罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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