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Nano-silver surface modified polyurethane central venous catheter and preparation method thereof

A central venous catheter, surface modification technology, applied in the direction of catheter, liquid chemical plating, metal material coating technology, etc., can solve the problems of variation, untreatable diseases, etc., and achieve long antibacterial validity period, strong antibacterial and anti-infection performance , good anti-infection effect

Inactive Publication Date: 2012-03-21
SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the abuse of chemical drugs such as antibiotics, more and more microorganisms have developed drug resistance through mutation, making some diseases caused by drug-resistant bacteria untreatable

Method used

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  • Nano-silver surface modified polyurethane central venous catheter and preparation method thereof
  • Nano-silver surface modified polyurethane central venous catheter and preparation method thereof
  • Nano-silver surface modified polyurethane central venous catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Soak a 15cm-long polyurethane central venous catheter in a mixed solvent of ethanol and deionized water with a volume ratio of 1:1 and ultrasonically clean it for 1 hour to remove the dirt on the surface of the catheter, take out the catheter, rinse it fully with deionized water, and put it in a vacuum After drying in the oven, weigh them.

[0035] Soak the dry polyurethane central venous catheter in 0.2mol / L AgNO 3 In aqueous solution (AgNO 3 directly dissolved in water), and irradiated at a distance of 10cm from the ultraviolet lamp for 20min, and finally the catheter was taken out, rinsed with a large amount of deionized water and soaked in water for 24h, during which the water was changed continuously, and vacuum-dried to constant weight.

[0036] The modified catheters with lengths of 15, 25, 35, and 45 mm were respectively taken for antibacterial ability test, and the obtained turbidities were 1.163, 0.533, 0.127, and 0.175 respectively; The turbidity of the ant...

Embodiment 2

[0038] Soak a 15cm-long polyurethane central venous catheter in a mixed solvent of ethanol and deionized water with a volume ratio of 1:1 and ultrasonically clean it for 1 hour to remove the dirt on the surface of the catheter, take it out and rinse it fully with deionized water, and put it in a vacuum drying oven After drying, weigh them.

[0039] Soak the dry polyurethane central venous catheter in 0.2mol / L AgNO 3 ethanol solution (AgNO 3 Dissolve in absolute ethanol, add water less than 2% of the total volume of the solution to help dissolve the remaining insoluble part, and mix the two), and irradiate for 20 minutes at a distance of 10cm from the ultraviolet lamp, finally take out the catheter, and then use a large amount of deionized Rinse with water and soak in water for 24 hours, change the water constantly, and vacuum dry to constant weight.

[0040] The modified catheters with lengths of 15, 25, 35, and 45 mm were respectively taken for antibacterial ability test, a...

Embodiment 3

[0042] Soak a 15cm-long polyurethane central venous catheter in a mixed solvent of ethanol and deionized water with a volume ratio of 1:1 and ultrasonically clean it for 1 hour to remove the dirt on the surface of the catheter, take it out and rinse it fully with deionized water, and put it in a vacuum drying oven After drying, weigh them.

[0043] Soak the dry polyurethane central venous catheter in 0.2mol / L AgNO 3 Aqueous solution (AgNO 3 Dissolve directly in water) for 2 minutes, take it out, then irradiate it at a distance of 10cm from the ultraviolet lamp for 20 minutes, finally take out the catheter, rinse it with a large amount of deionized water and soak it in water for 24 hours, change the water continuously, and vacuum dry to constant weight.

[0044] The modified catheters with lengths of 15, 25, 35, and 45 mm were respectively taken for antibacterial ability test, and the turbidities obtained were 1.515, 0.730, 0.908, and 0.338 respectively; The same length order...

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Abstract

The invention discloses a nano-silver surface modified polyurethane central venous catheter and a preparation method thereof. In the nano-silver surface modified polyurethane central venous catheter, a polyurethane central venous catheter is used as a matrix, and nano-silver is chemically plated on the surface of the matrix. The preparation method comprises the following steps: immersing the polyurethane central venous catheter in a mixed solvent of ethanol and deionized water for cleaning; taking out and drying, and immersing the dried polyurethane central venous catheter in silver nitrate solution; radiating with ultraviolet ray after the polyurethane central venous catheter is taken out; and washing and immersing with deionized water, regularly changing water during immersing, and finally drying to obtain the nano-silver surface modified polyurethane central venous catheter. The nano-silver surface modified polyurethane central venous catheter has strong antibacterial and anti-infection performance, and has wide application prospect.

Description

technical field [0001] The invention relates to a polyurethane central venous catheter with chemically plated nano-silver on the surface and a preparation method thereof. Background technique [0002] Medical polyurethanes mostly refer to non-foaming elastomers with structural features of segmented polyurethane (SPU). Compared with other interventional catheter materials (such as PE, PVC, PTFE and silicone rubber), it has excellent mechanical properties and blood compatibility, and is currently an ideal material for making interventional catheters. SPU is composed of soft segment formed by polyether diol and hard segment formed by diisocyanate and chain extender low molecular weight diamine or diol. The domains of rigid hard segments are dispersed in the continuous phase of soft segments to form sea-island structures. Its hard segment is hydrophobic and partially crystalline, and the soft segment is hydrophilic and amorphous. Since these two parts are incompatible, a so-c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/10A61L29/16C23C18/14A61L29/06A61M25/00
Inventor 祝方明丁侃贤陈翠欧阳习浩李志云杨立刘冉
Owner SUN YAT SEN UNIV
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