Preparation method for radiopolymerized slow-release high-polymer material

A technology of polymer materials and radiation polymerization, applied in the field of preparation of radiation polymerization slow-release polymer materials, can solve the problems of high radiation dose and unfavorable radiation polymerization, so as to reduce the radiation dose, eliminate the possibility and eliminate the adverse effects

Inactive Publication Date: 2012-03-21
余姚市顺诚电子加速器技术服务有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to address the defects of the prior art, overcome the adverse effects of normal temperature and aerobic conditions, and the shortcomings of high radiati

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment 1

[0017] Example 1: Immobilization of gonadotropins

[0018] Polymerization immobilization material: using dihydroxyethyl methacrylate (HEMA) and polyethanol dimethacrylic acid series monomer (14G): the former is formed after irradiation because it has a hydrophilic hydroxyl group and is a monofunctional monomer Porous soft gel with low cross-linking density and high flexibility, has a continuous and round microporous structure, good permeability, easy diffusion of substrates, embedded and immobilized enzymes or drugs and substrates can be Full reaction, high relative activity; the latter is a bifunctional monomer, the carrier formed after irradiation increases the cross-linking plot, hardness increases, the permeability of the microporous structure is poor, the diffusion of the substrate is limited, and the relative activity is low . Therefore, the proportion of the two should be determined according to the practical requirements by using complementary measures. The gonadotro...

Embodiment 2

[0023] Embodiment 2: Fix Gibberella

[0024] Polymerized fixed-ratio materials: Polymerized polymer materials are sodium acrylate (SA), HEMA and hydroxyethyl acrylate (HEA), the ratio of the three is 2:1:1, mixed evenly, and placed in a sealed test tube;

[0025] Degassing and filling with nitrogen: vacuumize the sealed test tube first, then introduce high-purity nitrogen, repeat three times to ensure that the test tube is saturated with high-purity nitrogen;

[0026] Low-temperature pre-cooling: Cool the test tube in a low-temperature storage below -18°C and store it in a thermos;

[0027] Irradiation: with 60 Co γ-ray or 5-10MeV electron beam irradiation, irradiation working dose 15kGy, irradiation dose unevenness 1.3;

[0028] Inoculation of Gibberella: Make polymeric polymer carrier into 5-10 mm small pieces, put them in distilled water to make them absorb water and swell, after sterilization, put them into Gibberella culture to make them saturated, then inoculate Gibber...

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Abstract

The invention relates to a preparation method for radiopolymerized slow-release high-polymer material. The method includes the following steps: slow-release material as high-polymer material blended according to different proportions or slow-release high-polymer material uniformly mixed with drug to be slowly released is put into a plastic container without chlorine atoms, sealed, vacuumized, then saturated with high-purity nitrogen, put into a thermal insulating container under minus 18 DEG C and irradiated by 60 Co Gamma rays or 5 MeV to 10MeV of electron beam, the radiation dose is 9.9kGy to 20kGy, the lowest effective dose is 9.9kGy, the maximum tolerated dose is 20kGy, the ununiformity of the radiation dose is lower than 1.3, the high-polymer material is polymerized, and the radiopolymerized slow-release high-polymer material is then produced into the shapes of tablets, granules and needles according to different purposes, and is used for fixing chemicals, enzyme and bacteria after water swelling. The invention overcomes the defects of the prior art, and provides the method for preparing the slow-release material, which can better promote radiopolymerization.

Description

technical field [0001] The invention relates to a radiation processing method in the application field of atomic energy science and technology, in particular to a preparation method of a radiation-polymerized slow-release polymer material that can be used for immobilization of drugs, enzymes, bacteria, etc. Background technique [0002] Sustained-release technology refers to immobilizing drugs, enzymes or bacteria in slow-release materials, and releasing them slowly and steadily within a certain period of time to maintain a certain effective concentration. Commonly used slow-release materials include alginate blue, chitosan, and gelatin. Since the 1990s, my country has begun to prepare polymer slow-release materials with new technology of radiation polymerization. In Lin Han et al. (2009) "Nuclear Technology" 2009 (5) 375-378 "Radiation Preparation of PEG / BCD / NIPAAM Hydrogel and Drug Controlled Release Research" introduced 2MeV 2mA electron beam, irradiated PEG-BCD and NIP...

Claims

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Application Information

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IPC IPC(8): C08F220/28C08F222/14C08F220/06C08F2/46C08F2/54A61K47/32C12N11/08
Inventor 施惠栋谢宗传
Owner 余姚市顺诚电子加速器技术服务有限公司
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