Method for effectively separating raceme and preparing homochiral substance

Abstract

The invention belongs to the technical field of chiral compound preparation, and specifically relates to a method for effectively separating raceme and preparing a homochiral substance. According to the invention, zeolite microcapsules (Pt@S1) with sealed catalytically active silicalite-1 are adopted as a catalyst; the catalyst is used in concerted catalysis with lipase (CALB), such that a homochiral substance is obtained. With the method, mutual influences between an active species Pt and enzyme, and intoxication are effectively prevented; one-step reaction of dynamic kinetic resolution can be realized with high efficiency; reaction efficiency can be improved; and reaction cost can be reduced. Also, according to the invention, with the tight protection of the zeolite microcapsules, loss of active species can be effectively prevented, and the catalyst can recycled and repeatedly used in practice, such that the service life of the catalyst can be improved. The applied catalyst is also characterized in adjustable shell thickness, adjustable catalytic active site number, easy separation, good stability, and the like. Therefore, the method is provided with better practicality and effectiveness.

Description

technical field [0001] The invention belongs to the technical field of preparation of chiral compounds, in particular to a method for one-step separation of racemates to prepare homochiral compounds. Background technique [0002] Pure optical enantiomers have important applications in chiral chemistry, agricultural chemistry, medicinal chemistry and other fields. At present, there are many methods to obtain pure chiral enantiomers, such as: chiral chromatographic separation technology, asymmetric synthesis method, kinetic resolution method and so on. Among them, the dynamic kinetic resolution (DKR) of amines is a relatively difficult subject. This is because the amine itself can be used as a ligand to combine with the active site of the metal, and the C-N bond may also be broken under the catalysis of the transition metal, which makes the hydrodehydrogenation and racemization of the amine difficult to proceed [Eur. J. Org. Chem. 2010, 999–1015], and the required conditions...

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Problems solved by technology

However, the main disadvantages of these catalysts are low reaction efficiency, low reaction selectivity, harsh reaction conditions, etc.

At the same time, the presence of metals may also cause interactions with enzymes, affecting the catalytic activity of metals and enzymes, and thus cannot effectively and highly selectively obtain pure chiral substances.

[0004] The noble metal Pt catalyst has good catalytic activity for hydrodehydrogenation, but because Pt will combine with sulfur-containing and nitrogen-containing substances in the enzyme, the enzyme and Pt will lose their activity at the same time, so it is rarely used in the racemization of phenethylamine. There are few reports

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