Tissue engineering bone cartilage composite bracket and integrated photocuringable forming method thereof

Abstract

The invention discloses a tissue engineering bone cartilage composite bracket and an integrated photocuringable forming method thereof. The tissue engineering bone cartilage composite bracket serves as a ceramic bracket, wherein the ceramic bracket is served as a bone-repair part, and a porous structure is arranged on the surface of the ceramic bracketbone-repair part of the porous structure; and the ceramic bracket is fixed on a supporting plate of a photocuringable quick forming machine. A laser scanning path is driven through a computer aided design (CAD) model; and laser directly exposes and cures a hydrogel bracket and a pure hydrogel bracket which contain a ceramic component onto the ceramic bracket sequentially to form a three-layer composite bracket. Therefore, quick and fine preparation of a three-dimensional composite bracket of bone cartilage-like tissue histomorphometry is realized; uncontrollable structures and low efficiency because of handwork in the preparation process of a traditional composite bracket are avoided; the preparation efficiency is improved; and a calcified cartilage-like layer bracket and a hydrogel cartilage bracket with subtle structures can be bonded and compounded on the surface of the ceramic bracket by means of a rivet and a two-phase material.

Description

technical field [0001] The invention relates to the technical field of biomanufacturing, in particular to a tissue engineering osteochondral composite scaffold and an integrated photocuring molding method thereof. Background technique [0002] Due to the limited self-repair ability of adult articular cartilage, surgical intervention is usually required for articular cartilage and bone defects in clinical practice, including arthroscopic debridement, microscopic microfracture, and osteochondral autografting. The above methods have disadvantages such as poor repair effect, limited by the patient's age and defect area, and limited sources of grafts. Through the research on the repair of artificial osteochondral defects in recent years, osteochondral tissue engineering has been developed deeply, and has shown great potential in clinical application. [0003] Osteochondral tissue engineering scaffolds include simple bone (cartilage) scaffolds, osteochondral composite scaffolds, ...

AI Technical Summary

Problems solved by technology

[0003] Osteochondral tissue engineering scaffolds include simple bone (cartilage) scaffolds, osteochondral composite scaffolds, and osteochondral composite scaffolds containing calcified cartilage layers. At present, most osteochondral composite scaffolds are mainly prepared by manual suturing and bonding. The process is complicated, the degree of automation and customization is low, and the structure of the composite stent is unstable. After the stent is implanted, delamination and peeling are easy to occur, and it cannot provide a good environment for the growth of new tissue and the fusion of the stent and the surrounding tissue. mechanical support environment

In addition, there is a layer of calcified cartilage between the natural osteocartilage, which plays a role in supporting the pressure bearing of cartilage and preventing blood vessel invasion. The preparation of traditional scaffolds does not take into account the transitional structure of preparing calcified cartilage layer scaffolds, but adopts 3D printing The layered structure scaffold prepared by the method has the problems of poor binding force and easy collapse after implantation.

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