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Resveratrol tetramer compound, its preparation method and application

A technology of resveratrol and compounds, applied in the field of medicine, to achieve the effect of simple process, clear medicinal ingredients, and remarkable effect of lowering uric acid

Inactive Publication Date: 2012-05-02
NANJING UNIV
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Problems solved by technology

[0005] At present, the treatment of gout and hyperuricemia mainly includes drugs that prevent endogenous purine synthesis (such as allopurinol) and drugs that promote uric acid excretion (probenecid, benzbromarone), while the natural product resveratrol four Polymer (Vaticaffinol) has not been reported for the prevention or treatment of hyperuricemia and gout

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  • Resveratrol tetramer compound, its preparation method and application
  • Resveratrol tetramer compound, its preparation method and application
  • Resveratrol tetramer compound, its preparation method and application

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Embodiment Construction

[0028] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0029]In order to better understand the essence of the present invention, the extraction and separation, pharmacological experiments and results of the resveratrol tetramer compound Vaticaffinol are used to illustrate its application in the preparation of prevention or treatment of hyperuricemia and gout medicine or health food .

[0030] The preparation method of resveratrol tetramer compound comprises the following steps:

[0031] (1) Alcohol extraction to prepare the extract: crush the twigs of Pteropterocarpa, pass through a 40-80 mesh sieve, and then continuously soak the twigs of Pteropterocarpa powder with ethanol with a concentration of 95-50%, and extracting, the number of times of extraction is 3 to 5 times, and the time of each time is 12 to 24 hours; the extracted extract is collected by filtration, evaporated to dryness by a...

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Abstract

The invention relates to a resveratrol tetramer compound and its preparation method. The preparation method comprises: (1) subjecting the twigs of dipterocarpus alatus to alcohol extraction for preparing extract, (2) conducting sample loading by a dry method, (3) carrying out elution with mobile phase eluent, and (4) performing gel column chromatography. The invention also relates to application of the resveratrol tetramer compound in medicaments for preventing or treating hyperuricemia and gout or in health food. The extraction and purification process of the resveratrol tetramer compound provided in the invention dose not employ a reversed phase and a semi-preparative column, so that the technology has simple process and high yield. In addition, compared with inventions directed at gout and hyperuricemia, the resveratrol tetramer compound of the invention is a monomeric compound, which, as a natural uric acid lowering agent, has clear effective components and an obvious uric acid lowering effect. Being able to serve as a quality standard, the compound of the invention is convenient and reliable, thus providing a scientific basis for its clinical application.

Description

technical field [0001] The invention relates to a resveratrol tetramer compound (Vaticaffinol) and its preparation method, as well as the application of the resveratrol tetramer compound (Vaticaffinol) in the prevention and treatment of hyperuricemia and gout, belonging to medical technology field. Background technique [0002] Resveratrol (resveratrol, referred to as Res) is a non-flavonoid polyphenol compound, and Japanese Tokaoka first obtained it from veratrol (Res veratrol) in 1940. Veratrum grangiflorum ) is separated from the root. In 1963, Nonomura et al proposed that resveratrol is an active ingredient of certain herbal medicines for treating inflammation, lipid metabolism disorders and cardiovascular diseases. With the in-depth research on resveratrol, it has been shown that resveratrol has anti-cancer, anti-oxidation, anti-bacterial, anti-inflammatory and other effects, and can be widely used in medicine, health products, food, cosmetics and other fields. [00...

Claims

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Application Information

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IPC IPC(8): C07D493/04A61K31/343A61P19/06A23L1/30
Inventor 戈惠明陈玉胜孔令东丁晓琴
Owner NANJING UNIV
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