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Method for extracting ellagic acid from pomegranate peels

An extraction method and pomegranate peel technology are applied in the field of extraction of effective components of traditional Chinese medicine, can solve the problems of low conversion rate, complicated technical operation, long extraction time and the like, and achieve the effects of increased yield, simple process, increased content and extraction efficiency

Inactive Publication Date: 2012-05-16
张守力
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] An object of the present invention is to solve the problems of long extraction time, low conversion rate and complex technical operation of the above-mentioned prior art, and provide a kind of ellagitation that is easy to operate, reliable in conversion, high in product recovery rate, and can meet the requirements of industrial production. acid extraction method

Method used

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  • Method for extracting ellagic acid from pomegranate peels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Processing of raw materials; charcoal frying: Remove the impurities, wash, slice, and dry the original pomegranate peel medicinal material in a hot pot at 300°C until the skin is dark brown and the inside is burnt brown, and slice it for later use.

[0028] Slicing was made into sheets with a thickness of 2 mm.

[0029] Extraction: In terms of mass, add 3 times of tap water to the treated raw material, soak at room temperature for 3 hours, then heat the mixture of the two to 90°C, keep it warm for 2 hours, two times in a row, take the liquid from the filter residue, and then add 8 times of 80% acetone was extracted at 80°C, and the combined filtrates were concentrated.

[0030] In terms of mass, the ratio of the specific gravity of the extracted concentrated solution to the raw material is 1:1.

[0031] Oxidative dehydrogenation: Hydrogen peroxide is added to the concentrated solution for hydrolysis, the ratio of hydrogen peroxide and extract is 20:1, the time is 30 mi...

Embodiment 2

[0034] Processing of raw materials; charcoal frying: remove impurities, wash, slice, and dry the original pomegranate peel medicinal material in a hot pot at 200°C until the skin is dark brown and the inside is burnt brown, sliced ​​or crushed for later use.

[0035] Pulverize to make raw material powder of about 80 mesh.

[0036] Extraction: In terms of mass, add 3 times the amount of tap water to the treated raw material, soak at room temperature for 6 hours, then heat the mixture of the two to 80°C, keep it warm for 4 hours, 3 times in a row, take the liquid from the filter residue, combine and concentrate.

[0037] In terms of mass, the ratio of the specific gravity of the extracted concentrated solution to the raw material is 1:1.

[0038] Oxidative dehydrogenation: add hydrogen peroxide to the extract for hydrolysis, the ratio of hydrogen peroxide to extract is 20:1, the time is 5 minutes, filter and recover the hydrogen peroxide liquid, concentrate the recovered solutio...

Embodiment 3

[0041] Processing of raw materials; charcoal frying: remove impurities, wash, slice, and dry the raw pomegranate peel medicinal material in a hot pot at 400°C until the skin is dark brown and the inside is burnt brown, sliced ​​or crushed for later use.

[0042] Slicing was made into pieces with a thickness of 1 mm.

[0043] Extraction: In terms of mass, add 10 times the amount of tap water to the treated raw material, soak at room temperature for 0.5 hours, then heat the mixture of the two to 100°C, keep it warm for 4 hours, 4 times in a row, take the liquid from the filter residue, and add it to the filtrate 5 times 80% acetone extraction at 80°C, combined extracts and concentrated,

[0044] In terms of mass, the ratio of the specific gravity of the extracted concentrated solution to the raw material is 1:1.

[0045] Oxidative dehydrogenation: add hydrogen peroxide to the extract for hydrolysis, the ratio of hydrogen peroxide to extract is 20:1, the time is 5 minutes, filte...

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Abstract

The invention relates to the field of drug preparation, in particular a method for extracting ellagic acid from pomegranate peels, solving the problems existing in the prior art that the conversion rate is lower, and the yield is low and the product quality is bad. The process is as follows: treatment on raw materials; extraction; oxidative dehydrogenation; purification. The method disclosed by the invention largely raises the production efficiency and the conversion rate, and makes effective substances in the raw materials more converted into ellagic acid, and further raises the product quality and purity, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a method for extracting active ingredients of traditional Chinese medicines, in particular to a method for extracting ellagic acid from pomegranate peel. Background technique [0002] Method for extracting ellagic acid from pomegranate peel [0003] [0004] Reference: 200810056007.x; 200510002081.x; cn101701234A; CN101768165; CN101747388A. [0005] Pomegranate peel is the dry peel of Punica Granatum L., a plant of the family Pomegranate. , Punicalagin, Pomegranate A, Pomegranate B, Galloyl Dilactone, etc. Among them, ellagic acid is a dimeric derivative of gallic acid, which is a polyphenol dilactone with a molecular formula of C14H6O8, as shown in the molecular structure diagram above. [0006] Modern studies have proved that ellagic acid has obvious inhibitory effects on chemical substance-induced carcinogenesis and other carcinogenesis, especially colon cancer, esophageal cancer, liver cancer, lung cancer, tongue and ...

Claims

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Application Information

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IPC IPC(8): C07D493/06
Inventor 张守力
Owner 张守力
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