Method for disposing residues produced by fermentation of cephalosporin C through alkaline hydrolysis process

A technology for treating cephalosporin and head, which is applied in the field of residue treatment produced in the fermentation process of cephalosporin C, which can solve problems such as human health hazards and environmental pollution, achieve high ecological safety, simple process and equipment, and easy industrialization The effect of production

Active Publication Date: 2012-06-13
天津市裕川环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] During the production of cephalosporin C by fermentation, a large number of residues will be produced. These residues contain fermentation residual mother liquor nutrients, suspended solids, refractory organic matter and biotoxic substances such as DCPC and DOCPC, whic

Method used

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Experimental program
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Effect test

Embodiment 1

[0020] A kind of method of alkali hydrolysis process processing cephalosporin C production residue, comprises the steps:

[0021] 1), the pretreatment of cephalosporin C production residue: add 50kg of cephalosporin C production residue and lime water in the 100L mixing tank, make the pH of the mixed solution be 9 by controlling the addition of lime water, cover and seal Cover, electric stirring for 20min, and pump the evenly stirred mixture into a 100L hydrolysis reaction kettle.

[0022] 2) Hydrolysis: The hydrolysis process uses a sealed hydrolysis reactor, heats the reactor with heat transfer oil and keeps it warm. Under the conditions of working pressure of 0.4Mpa and hydrolysis temperature of 165°C, the hydrolysis time is 3 hours. Start the stirring device to stir the mixed solution in the hydrolysis reaction kettle.

[0023] 3) Filtration: After the hydrolysis is completed, the mixed liquid after hydrolysis is separated from solid and liquid by plate and frame filter p...

Embodiment 2

[0025] A kind of method of alkali hydrolysis process processing cephalosporin C production residue, comprises the steps:

[0026] 1), the pretreatment of cephalosporin C production residue: add 50kg of cephalosporin C production residue and lime water in the 100L mixing tank, make the pH of the mixed solution be 10 by controlling the addition of lime water, cover the sealing cap , electric stirring for 20min, and pump the evenly stirred mixture into a 100L hydrolysis reaction kettle.

[0027] 2) Hydrolysis: The hydrolysis process uses a sealed hydrolysis reactor, heats the reactor with heat transfer oil and keeps it warm. Under the conditions of working pressure of 0.6Mpa and hydrolysis temperature of 200°C, the hydrolysis time is 1.5h, and the heat preservation during the hydrolysis process Simultaneously start the stirring device to stir the mixed solution in the hydrolysis reaction kettle.

[0028] 3) Filtration: After the hydrolysis is completed, the mixed liquid after hy...

Embodiment 3

[0030] A kind of method of alkali hydrolysis process processing cephalosporin C production residue, comprises the steps:

[0031] 1), the pretreatment of cephalosporin C production residue: join 50kg of cephalosporin C production residue and sodium hydroxide solution in the 100L mixing tank, make the pH of mixed solution be 11 by controlling the addition of sodium hydroxide solution, Cover the airtight lid, stir it electrically for 20 minutes, and pump the evenly stirred mixture into a 100L hydrolysis reaction kettle.

[0032] 2) Hydrolysis: The hydrolysis process uses a sealed hydrolysis reactor, heats the reactor with heat transfer oil and keeps it warm. Under the conditions of working pressure of 0.65Mpa and hydrolysis temperature of 210°C, the hydrolysis time is 1.0h, and the heat preservation during the hydrolysis process Simultaneously start the stirring device to stir the mixed solution in the hydrolysis reaction kettle.

[0033] 3) Filtration: After the hydrolysis is ...

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PUM

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Abstract

The invention relates to a method for disposing residues produced by fermentation of cephalosporin C through an alkaline hydrolysis process, which comprises the following steps: putting the disposing residues produced by the cephalosporin C in aqueous alkali so as to be heat and hydrolyzed, wherein the working pressure is 0.4-0.7 Mpa, the hydrolysis temperature is 150-220 DEG C, and the hydrolysis time is 1-3h; and filtering after hydrolysis, and respectively collecting filtrate and filter residues. The process and equipment provided by the invention are simple, has low cost, high efficiency, less pollution, and is easy to industrial production; and the obtained filtrate and filter residues realize full degradation of antibiotics and intermediate products thereof, so that higher ecological safety is realized.

Description

technical field [0001] The invention relates to a treatment method for waste residues produced in the pharmaceutical industry, in particular to a treatment method for residues produced in a cephalosporin C fermentation process. Background technique [0002] The cephalosporin antibiotic industry has developed into an important industry accounting for more than 40% of the world's sales of anti-infective drugs. At present, the main production method of cephalosporin antibiotics is to produce the important component "cephalosporin C" of such drugs through fermentation, and then produce cephalosporins through fine processing. However, during the fermentation process, various intermediate substances with similar structures to "cephalosporin C" will be produced, such as 7-aminocephalosporanic acid (7-ACA), deacetylcephalosporin (DCPC) and deacetyloxygen Cephalosporin (DOCPC) and so on. [0003] These intermediate substances can have a certain impact on the production of cephalosp...

Claims

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Application Information

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IPC IPC(8): A62D3/36C05F5/00A62D101/28
CPCY02A40/20
Inventor 左健王广志于洋吴瑞华刘成林
Owner 天津市裕川环境科技有限公司
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