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Method for preparing edge rigidized artificial biological valve

A technology of biological valve and edge rigidity, which is applied in the field of medical devices, can solve the problems of cardiac dysfunction, long stent length, unsatisfactory opening design, etc., and achieve the effect of improving long-term stability and durability and enhancing edge rigidity

Active Publication Date: 2014-01-15
SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages and problems of this balloon-expandable biological valve are: in the process of stent compression and balloon expansion, the leaflet tissue structure of the biological valve will be greatly damaged, which seriously affects the service life of the heart valve after implantation
The disadvantages and problems of this self-expanding biological valve are: the length of the stent is too long, the opening design is not ideal, and it is easy to affect the hemodynamics of the left and right coronary ostia, resulting in cardiac dysfunction; Once the heart valve is implanted, if there is a problem, it cannot be recovered and can only be replaced by surgery
[0007] Document 1 [Hsing-Wen Sung, Yen Chang, Chi-Tung Chiu, Chiun-Nan Chen, Huang-Chien Liang. Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent. Biomaterials, 1999, 20: 1759-1772 】Using genipin to treat the collagen fibers in the artificial biological valve, and compared with the traditional glutaraldehyde method, it is found that the effect of genipin anti-calcification treatment is better than the traditional glutaraldehyde treatment method, but it has no effect on the Analysis of edge damage phenomenon of bioprosthetic valve
[0008] Document 2 [Peter Angele, Jochen Abke, Richard Kujat, Hubert Faltermeier, Detlef Schumann, Michael Nerlich, Bernd Kinner, Carsten Englert, Zbigniew Ruszczak, Robert Mehrl, Rainer Mueller. Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices.Biomaterials, 2004, 25: 2831-2841] Carboimide was used to treat the collagen fibers in the artificial biological valve, and its mechanical properties and swelling properties were studied, but the overall durability of the artificial biological valve was not studied. processing and research

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  • Method for preparing edge rigidized artificial biological valve
  • Method for preparing edge rigidized artificial biological valve
  • Method for preparing edge rigidized artificial biological valve

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The bioprosthetic valve was fixed in 0.625% glutaraldehyde / 0.5% hydroxyethylpiperazineethanesulfonic acid compound buffer solution (pH 7.4) for 3 days.

[0027] Put the bioprosthetic valve pretreated with glutaraldehyde into PBS buffer solution (pH 6.8) containing 0.5% sodium borohydride for modification for 5 hours.

[0028] The bioprosthetic valve pretreated with glutaraldehyde and treated with sodium borohydride solution was put into 0.5% myrica rubra extract in PBS solution (pH 6.8) for 2 days.

Embodiment 2

[0030] The bioprosthetic valve was fixed in 0.625% glutaraldehyde / 0.5% anhydrous morpholinoethanesulfonic acid compound buffer solution (pH 7.4) for 15 days.

[0031] Put the glutaraldehyde-pretreated bioprosthetic valve into PBS buffer solution (pH 6.8) containing 0.5% sodium borohydride for modification for 10 hours.

[0032] The bioprosthetic valve pretreated with glutaraldehyde and treated with sodium borohydride solution was put into 0.5% wattle extract in PBS buffer solution (pH 6.8) for 3 days.

Embodiment 3

[0034] The bioprosthetic valve was fixed in 0.625% glutaraldehyde / 0.5% tris buffer solution (pH 7.4) for 20 days.

[0035] The bioprosthetic valve pretreated with glutaraldehyde was modified in Hank's buffer solution (pH 6.8) containing 1% sodium borohydride for 20 hours.

[0036] The bioprosthetic valve pretreated with glutaraldehyde and treated with sodium borohydride solution was put into Hank's buffer solution (pH 6.8) of 1% quebracho extract for 7 days.

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Abstract

A method for preparing an edge-rigidized artificial biological valve comprising: first soaking an artificial biological valve in a pretreated glutaraldehyde solution, wherein the artificial biological valve can be partly fixed with glutaraldehyde before, after or during contact with the pretreated glutaraldehyde solution; and then closing the free aldehyde groups, carboxyl groups, amino groups, hydroxyl groups and carbonyl groups formed by the artificial biological valve pretreated with glutaraldehyde with a reducing agent and tannin extract. The edge rigidity of the artificial biological valve is enhanced, so that the long-term stability and durability of the artificial biological valve are improved.

Description

technical field [0001] The invention relates to the field of medical instruments. More specifically, the present invention relates to a preparation method of an artificial biological valve (membrane) with rigid edges. Background technique [0002] The development of artificial biological (heart) valves has always been one of the subjects of research in the field of cardiac surgery. The criteria for an ideal bioprosthetic valve are good durability and biocompatibility, hemodynamic performance close to that of a physiological valve, little damage to blood cells, easy implantation, anti-infection, and non-immunogenicity. [0003] Minimally invasive interventional artificial biological valves (membranes) include balloon-expandable biological valves and self-expandable biological valves. [0004] The balloon-expandable biological valve is a plastically deformable stent fixed artificial biological valve. The stent is radially compressed to fix it on the balloon, and the stent i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61F2/24C08J3/24
CPCA61L27/24A61F2/2415A61F2250/0029A61L2430/20A61L27/3625A61L27/3687A61L2400/02
Inventor 陈大凯李雨田聪房圆董教明陈诚程秀兰陈国明乐承筠罗七一
Owner SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD