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Preparation and application of isononyl ferulate as cosmetic additive with whitening and sunscreen functions

A technology of isononyl ferulate and ferulic acid, which is applied in the field of preparation of a new whitening sunscreen agent - isononyl ferulate, can solve the problems that no one has reported the preparation of isononyl ferulate

Inactive Publication Date: 2012-06-20
GUANGDONG IND TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no one has reported the preparation of isononyl ferulate proposed by the present invention

Method used

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  • Preparation and application of isononyl ferulate as cosmetic additive with whitening and sunscreen functions
  • Preparation and application of isononyl ferulate as cosmetic additive with whitening and sunscreen functions
  • Preparation and application of isononyl ferulate as cosmetic additive with whitening and sunscreen functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of embodiment 1 isononyl ferulate (direct heating method)

[0014] Add ferulic acid, isononyl alcohol, water-carrying agent (using cyclohexane, or xylene), catalyst (using p-toluenesulfonic acid, or sulfamic acid, or sodium bisulfate). Heat in an oil bath and stir to dissolve the solids. After the solid dissolves, keep stirring at a constant speed. When the temperature reaches about 90°C, start to reflux and keep reflux for 1 to 6 hours until no more water is generated and the reaction ends. Then cool to room temperature, add appropriate amount of NaHCO 3 Saturated solution (or mass fraction is the sodium carbonate solution of 10%), leave standstill to separate organic layer, after washing with water again, after vacuum distillation removes unreacted n-octanol, light yellow liquid is obtained, which is the present invention. isononyl ferulate compound.

Embodiment 2

[0015] The preparation of embodiment 2 isononyl ferulate (microwave assisted method)

[0016] Add ferulic acid, isononanol, water-carrying agent (use cyclohexane or xylene as water-carrying agent), catalyst (use p-toluene) in the microwave reactor equipped with agitator, reflux condenser and water separator Sulfonic acid, or sulfamic acid, or sodium bisulfate as a catalyst). Use microwave (200W-600W) to irradiate for 20min-40min. Keep stirring at a constant speed during the reaction. After the reaction was finished, cool to room temperature, add appropriate amount of NaHCO 3 Saturated solution (or mass fraction is the sodium carbonate solution of 10%), leave standstill to separate organic layer, after washing with water again, after vacuum distillation removes unreacted n-octanol, light yellow liquid is obtained, which is the present invention. isononyl ferulate compound.

[0017] 2. Preparation of cosmetics containing isononyl ferulate

[0018] The preparation of embodim...

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Abstract

The invention discloses synthesis of isononyl ferulate as cosmetic additive with both whitening and sunscreen functions and application of isononyl ferulate in cosmetics. Isononyl ferulate is synthesized by esterification of ferulic acid and isononyl alcohol as major raw materials in the presence of p-toluenesulfonic acid (or sulfamic acid or sodium hydrogen sulfate) as catalyst. Isononyl ferulate has both the whitening function of inhibiting production of skin melanin and the sunscreen function of absorbing UV, and can be used as a whitening agent in whitening cosmetic production and also used as a sunscreen agent in sunscreen cosmetic production. Isononyl ferulate is modified from a natural compound ferulic acid by esterification; has the advantages of good whitening effect, high safety, stable chemical property, easily-accessible raw material and low cost; overcomes the problems of hydroquinone, superoxide dismutase (SOD), vitamin C and other common whitening agents, such as severe irritation, poor stability, non-ideal effect and high price; and has good application prospects.

Description

technical field [0001] The invention relates to the preparation of a novel whitening sunscreen agent-isononyl ferulate. The compound has good functions of inhibiting skin melanin and absorbing ultraviolet rays, and can be used as a whitening agent and sunscreen agent in cosmetics. Background technique [0002] Skin whitening research has always been a hot spot in the cosmetics industry and the pharmaceutical industry, and cosmetics with the concept of whitening have become the best-selling cosmetics. At present, there are major defects in the management and technology of whitening cosmetics in my country. The phenomenon of illegal addition is very serious. Some even use contraband such as mercuric chloride as whitening agent or add peroxide such as hydrogen peroxide for bleaching. Many beauty accidents, even disfigurement, have caused great harm to consumers, and have attracted great attention from the country and consumers. In recent years, the whitening agents used in cosm...

Claims

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Application Information

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IPC IPC(8): C07C69/734C07C67/08A61K8/37A61Q19/02A61Q17/04
Inventor 龚盛昭
Owner GUANGDONG IND TECHN COLLEGE
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