Fiber surface plasmon resonance glucose sensor with temperature self-compensation

Abstract

The invention relates to a fiber surface plasmon resonance glucose sensor with temperature self-compensation. The fiber surface plasmon resonance glucose sensor comprises a fiber core; a fiber cladding wraps the periphery of the fiber core; a fiber grating is written in a 10-30mm section of the fiber core; and a chromium layer, a gold film and a glucose molecule specific adsorption layer are arranged on the periphery of a 15-30mm section of the fiber cladding from inside to outside. Fiber is single mode fiber; the fiber grating is a long-period fiber grating or a tilted fiber grating; the thickness of the chromium layer is 3-5 nm; and the thickness of the gold film is 30-60 nm. The fiber surface plasmon resonance glucose sensor has the advantages of simple structure, small volume, anti-electromagnetic interference and corrosion resistance, can be easily combined with a tissue fluid transdermal extraction chip so as to manufacture a miniaturized instrument, and meanwhile, is suitable for implanted measurement. With the adoption of the fiber surface plasmon resonance glucose sensor with temperature self-compensation, the measurement errors arising from temperature and the interference on measurement caused by external environments can be reduced.

Description

technical field [0001] The invention relates to an optical fiber surface plasmon resonance (SPR) glucose sensor. In particular, it relates to an optical fiber surface plasmon resonance glucose sensor with temperature self-compensation, which includes an optical fiber core, an optical fiber cladding, an optical fiber grating, a chromium layer, a gold film, and a glucose molecule-specific adsorption layer. Background technique [0002] With the improvement of people's living standards, changes in lifestyle, population aging and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. Diabetes is a chronic metabolic disease characterized by high blood sugar. Long-term high blood sugar in diabetes often causes damage to many tissues, especially the eyes, nerves, heart and blood vessels, leading to functional defects and failure. Therefore, the World Health Organization lists it together with tumors and cardiovascular and cerebrovascular d...

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Problems solved by technology

However, since the interstitial fluid contains complex components other than glucose, the measurement is easily disturbed; at the same time, the optical fiber SPR measurement is also affected by the change of the external environment temperature, and the measurement error is large.

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