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Ion chromatography-ultraviolet detection method for measuring content of captopril in captopril medicine

An ion chromatography and external detection technology, which is applied in the direction of measuring devices, material separation, instruments, etc., can solve the problems of long time consumption and low sensitivity, and achieve the effect of short analysis time, high sensitivity and simple pretreatment

Inactive Publication Date: 2012-06-27
ZHEJIANG UNIV
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Problems solved by technology

Although some detection methods are simple, they take a long time and have low sensitivity
The amino group contained in the structure of captopril exists in the form of organic cations in an acidic environment, which is more suitable for separation and detection by ion chromatography; so far, there has been no report on the determination of the drug content of captopril by ion chromatography-ultraviolet detection

Method used

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  • Ion chromatography-ultraviolet detection method for measuring content of captopril in captopril medicine
  • Ion chromatography-ultraviolet detection method for measuring content of captopril in captopril medicine
  • Ion chromatography-ultraviolet detection method for measuring content of captopril in captopril medicine

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Embodiment Construction

[0017] The technical scheme of the present invention is further specifically described below by specific examples:

[0018] Determination of Captopril in Captopril Tablets by Ion Chromatography-Ultraviolet Detection

[0019] 1. Preparation of standard solution: Accurately weigh 10 mg of captopril standard sample, add 50% acetonitrile into a 10 ml volumetric flask, shake to dissolve, and set the volume to the mark;

[0020] 2. Preparation of standard curve: prepare standard solutions with different concentrations by step-by-step dilution;

[0021] 3. Sample pretreatment: remove the coating of the tablet, grind it into powder, add 50% acetonitrile after accurate weighing to dissolve, ultrasonic for 15 minutes, wait to cool to room temperature, and quantify to the scale line. After diluting to an appropriate concentration, filter through a 0.45μm filter;

[0022] 4. Selection of eluent: test different eluent ratios, and finally determine that: 30% acetonitrile + 5% 50mM methane...

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Abstract

The invention provides a novel method for detecting captopril. An ion chromatography cation exchange system and an ultraviolet detector are combined, appropriate separation conditions are selected according to the difference of the retention behavior of a substance on a chromatographic column, and the optimal ultraviolet detection wavelength is selected, so that the captopril can be separated and detected at relatively high sensitivity, and the method can be used for the detection of the content of the captopril in a captopril medicine, human body fluid pharmacokinetic study and the like.

Description

technical field [0001] The invention relates to an application system for chemical instrument analysis, in particular to an ion chromatography-ultraviolet detection system for detecting captopril. Background technique [0002] Captopril belongs to angiotensin-converting enzyme inhibitor (ACEI) and is a kind of antihypertensive drugs. Captopril, perindopril, lisinopril and trandolapril have the most side effects, and non-specific side effects include nausea, vomiting and other gastrointestinal reactions, headache, dizziness and other nervous system side effects. Common analysis methods are HPLC separation, ultraviolet, electrochemical, evaporative light scattering, and near-infrared spectroscopy, as well as titration and optical rotation detection. Although some detection methods are simple, they are time-consuming and have low sensitivity. The amino group contained in the structure of captopril exists in the form of organic cations in an acidic environment, which is more s...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 刘玉秀周丹朱岩
Owner ZHEJIANG UNIV
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