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Bear bile extractive, preparation and application in preparing medicaments for treating scalds

A technology of extract and bear bile, which is applied in the field of medicine, can solve the problems of complex preparation process and cumbersome operation method, and achieve the effect of simple preparation process, strong quality controllability and high healing rate

Active Publication Date: 2012-07-04
福建归真堂药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of the above-mentioned compound Chinese medicine compositions is complicated, and the operation method is loaded down with trivial details

Method used

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  • Bear bile extractive, preparation and application in preparing medicaments for treating scalds
  • Bear bile extractive, preparation and application in preparing medicaments for treating scalds
  • Bear bile extractive, preparation and application in preparing medicaments for treating scalds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Preparation of bear bile powder alcohol extract

[0041]Add 2L methanol to 250g bear bile powder, after stirring and dissolving, filter, the filter residue is washed twice with 500ml methanol, and the 2 washings are merged into the filtrate to obtain a bear bile methanol solution;

[0042] The methanol solution of bear bile was evaporated to dryness to obtain 241 g of bear bile alcohol extract.

[0043] 2. Macroporous resin column separation

[0044] 1) Alternately wash the D101 macroporous resin with ethanol and distilled water until the washing liquid is clear, then wash with distilled water until there is no ethanol, and set aside;

[0045] 2) get 230g bear bile alcohol extract and dissolve in water, make bear bile aqueous solution, wherein the weight of adding water is 1kg, and the weight ratio with bear bile alcohol extract is 4.35: 1;

[0046] 3) the bear bile aqueous solution is passed through the macroporous resin column, and the flow velocity of the bear b...

Embodiment 2

[0052] Prepare bear bile powder ethanol extract step, except that extracting solvent is ethanol, and ethanol consumption is 1.5L, except that 230g bear bile alcohol extract is obtained, all the other are identical with embodiment 1;

[0053] Macroporous resin separation step, except selecting 4600g HPD100 type resin for use, the weight ratio of HPD100 type resin and ursool extract is 20: 1, and the column diameter of macroporous resin column and the ratio of column height are outside 1: 2.5, All the other are identical with embodiment 1.

[0054] The content of tauroursodeoxycholic acid in the obtained bear bile extract determined by HPLC method was 20.5%; the content of taurochenodeoxycholic acid was 62.8%.

Embodiment 3

[0055] Embodiment 3: preparation bear bile extract scald ointment

[0056] Prescription: a total of 1000g is prepared, and the components and contents are as follows:

[0057] Bear bile extract 165g

[0058] Vaseline 785g

[0059] Lanolin 50g

[0060] After the bear bile extract is crushed into fine powder, vaseline and lanolin are added, heated, filtered, allowed to cool until semi-solidified, and the bear bile extract scald ointment is prepared.

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Abstract

The invention relates to a bear bile extractive obtained from a traditional Chinese medicine bear bile powder as well as a preparation method and application in preparing medicaments for treating scalds. The bear bile extractive is obtained by extracting the bear bile powder by using an extracting solvent and then carrying out macroporous resin column separation after drying extracting solution. The result of a mice wound surface healing test indicates that the bear bile extractive prepared by the preparation method has high healing rate of scalded wound surfaces and short healing time, pathological examinations indicate that the renascent skin texture of the treated mice is intact and tight in arrangement, and has no obvious scar generation. The preparation method of the bear bile extractive has simplicity and low cost, and the bear bile extractive and the preparation method in the invention provide a new medicament source for treating the scalds.

Description

technical field [0001] The invention relates to a composition of bile acids, its preparation method and its application in the preparation of medicines for preventing and treating scalds, in particular to an extract of bear bile, its preparation method and its application in the preparation of medicines for preventing and treating scalds. The application in the invention belongs to the field of medical technology. Background technique [0002] Burns are tissue damage caused by physical, chemical, radiation and many other factors acting on the body, mainly targeting the skin and (or) mucous membranes, and in severe cases will also damage the subcutaneous tissue. It is an extremely complicated traumatic injury. Diseases, there are four major problems of wound pain, progressive necrosis, susceptibility to infection, and scar healing. [0003] Relevant medicines for the treatment of burns and scalds are divided into western medicines and traditional Chinese medicines, each of w...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61P17/02
Inventor 陈志鸿陈海峰张晓坤罗强许光辉陈全成陈丽玲吴德培
Owner 福建归真堂药业股份有限公司
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