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Production method and application of high-quality stable red-rooted salvia medicinal material

A technology of salvia miltiorrhiza and medicinal materials, which is applied in the field of medicine, can solve problems such as unclear key links, difficulties in preparation quality control, cost reduction, easy hydrolysis in storage, etc., and achieve the effects of increasing content and stability, increasing yield, and improving quality

Inactive Publication Date: 2012-07-04
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there are many factors affecting the quality of Danshen medicinal materials and the key links are not clear, it is still difficult to effectively control the quality of medicinal materials
In addition, since both tanshinones and salvianolic acids are chemical components of Danshen, they need to be effectively separated during the preparation process; salvianolic acids, especially its main component salvianolic acid B, are both It is prone to hydrolysis, which also causes great difficulties and costs for the quality control of related preparations

Method used

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  • Production method and application of high-quality stable red-rooted salvia medicinal material
  • Production method and application of high-quality stable red-rooted salvia medicinal material
  • Production method and application of high-quality stable red-rooted salvia medicinal material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1. Rapid drying method of high-quality salvia miltiorrhiza with significantly increased content of salvianolic acid B and tanshinone active ingredients

[0028] Materials and Methods: The fresh salvia miltiorrhiza was collected in Linqu, Shandong in November 2008. The collected fresh medicinal materials were brought back to the laboratory within two days, cut into 1-2 mm thin slices after removing the sediment, mixed evenly, stored in a -20°C refrigerator, and taken out in batches for drying process optimization research. The moisture content in the sample was determined according to the first method (drying method) of Appendix IX H of "Chinese Pharmacopoeia" (Part One); in the sample, there were 5 kinds of salvianolic acid B, dihydrotanshinone I; cryptotanshinone; tanshinone I and tanshinone IIA The content determination of main active ingredients adopts HPLC method.

[0029] Experimental results: Such as figure 1 , figure 2 The results showed that t...

Embodiment 2

[0030] Example 2. Combination drying process of high-quality salvia miltiorrhiza medicinal materials with significantly improved salvianolic acid B and tanshinone active ingredients

[0031] Materials and Methods: Fresh salvia miltiorrhiza was collected in Linqu County, Shandong Province in mid-October 2010. The collected fresh medicinal materials were brought back to the laboratory within two days, and after removing the sediment, they were stored in a -20°C refrigerator as a whole. For the preliminary experiment, about 3Kg of the whole sample was placed on the cement floor to dry, and about 100g was collected around 5:00 pm every day, sliced ​​and crushed immediately, and the water content in the sample and the content of 13 active ingredients such as salvianolic acid B were measured respectively. Then according to the determination results, the optimal drying process combination of Danshen medicinal materials was formulated. The water content in the sample was determi...

Embodiment 3

[0033] Example 3. Preparation method of total phenolic acid extract of salvia miltiorrhiza, effectively increasing salvianolic acid B content and yield and significantly reducing production cost

[0034] Materials and Methods: Fresh salvia miltiorrhiza was collected in Linqu County, Shandong Province in mid-October 2010. The collected fresh medicinal materials were brought back to the laboratory within two days. Take a whole sample of about 2Kg and put it on the cement floor to dry for 3 days, then cut the medicinal material into 2-3mm thin slices to obtain 620g of Danshen medicinal raw material with a humidity of about 20-15%. Cut the raw material into 2-3mm thin slices, extract twice with 6.0Kg of 70% acetone, filter, combine the extracts, and recover acetone. The concentrated water extract is diluted with 3 times the original volume of deionized water, filtered, and the clarified filtrate is adsorbed by a resin column equipped with 1.0Kg D101 macroporous adsorption res...

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Abstract

The invention belongs to the technical field of medicines, in particular relates to a production method of a high-quality red-rooted salvia medicinal material, and provides an application of the medicinal material in preparing red-rooted salvia extract and a red-rooted salvia preparation. According to the invention, a combined drying method of quick bake drying or airing, drying in shade, lyophilizing and quick baking is adopted, the formation and improvement of salvianolic acid B and tanshinone IIA and other active components are promoted, thus a high-quality red-rooted salvia medicinal material with high content of effective components and stable and controllable quality can be obtained; and the high-quality red-rooted salvia raw material prepared by utilizing the method is used for preparing total salvianolic acid extract, total tanshinone extract, salvianolic acid B, tanshinone IIA and other active medicinal intermediates, and various red-rooted salvia preparations of the medicinal material. According to the production method, the quality and stability of the red-rooted salvia medicinal material and related products can be greatly improved, and the resource utilization and economical benefit are increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, specifically a method for producing high-quality salvia miltiorrhiza medicinal material, and provides the application of the salvia miltiorrhiza medicinal material in preparing salvia miltiorrhiza extract and salvia miltiorrhiza preparation. Background technique [0002] Salvia miltiorrhiza is a plant of the labiatae family Salvia miltiorrhiza ( Salvia miltiorrhiza Bge . ) dry roots and rhizomes, which have the functions of promoting blood circulation and removing blood stasis, dredging menstruation and relieving pain, clearing heart and eliminating troubles, cooling blood and eliminating carbuncle, and are widely used in Chinese medicine for chest wall pain, wrist and abdomen pain, irregular menstruation, dysmenorrhea and other diseases . Its active ingredients are mainly water-soluble salvianolic acid compounds and fat-soluble tanshinone compounds. The former mainly includes danshensu, pro...

Claims

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Application Information

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IPC IPC(8): A61K36/537
Inventor 周铜水周国军李小兵王伟谢小梅
Owner FUDAN UNIV
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