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Preparation method of extracts of effective fractions of lychee seeds

A technology of effective parts and lychee pits is applied in the field of preparation of extracts from effective parts of traditional Chinese medicine lychee pits, which can solve the problems of unmentioned extraction and the like, and achieve the effects of complete extraction, clear composition and easy operation.

Active Publication Date: 2012-07-04
GUANGZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN 102048885A discloses a litchi nucleus saponin extraction process, which can extract the effective components of litchi nucleus, and the extracted litchi nucleus saponin content is as high as 85.0%, but also does not mention the extraction of multiple effective fraction groups

Method used

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  • Preparation method of extracts of effective fractions of lychee seeds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Crush the lychee pits into a coarse powder. Take 100g of lychee seed powder, add 1000ml of 70v / v% ethanol for the first time, soak for 0.5 hours, then ultrasonically extract for 1 hour, pour the extract A into the container for later use. Continue to add 800ml of 70v / v% ethanol to the medicinal residues, after soaking for 1 hour, ultrasonically extract for 1 hour, pour out the extract B, and combine it with the extract A obtained by the first extraction. The combined extract A and extract B are recovered to ethanol until there is no alcohol smell. The recovery method is preferably vacuum distillation recovery (vacuum degree -0.1MPa, temperature 75°C). The medicinal solution after recovery of ethanol was diluted with distilled water to 250ml, left standing overnight, filtered, and the filtrate was set aside. The filtrate first passes through the treated AB-8 macroporous resin column at a flow rate of 2 times the column bed volume per hour (see below for the treatment m...

Embodiment 2

[0032] Crush the lychee pits into a coarse powder. Take 100g of lychee seed powder, add 800ml of 70v / v% ethanol for the first time, soak for 1 hour, ultrasonically extract for 1 hour, and pour the extract A into the container for later use. Continue to add 1000ml of 70v / v% ethanol to the dregs, soak for 0.5 hours, ultrasonically extract for 1 hour, pour out the extract B, and combine it with the extract A obtained by the first extraction. The combined extract A and extract B are recovered to ethanol until there is no alcohol smell. The recovery method is preferably vacuum distillation recovery (vacuum degree -0.1MPa, temperature 75°C). The medicinal solution after recovery of ethanol was diluted with distilled water to 250ml, left standing overnight, filtered, and the filtrate was set aside. The filtrate first passed through the treated AB-8 macroporous resin column at a flow rate of 2 times the column bed volume per hour, then eluted with pure water of 3 times the amount of...

Embodiment 3

[0035] Example 3 Pilot Scale-Up Test

[0036] Weigh 10Kg of lychee kernel coarse powder, add 100L of 70v / v% ethanol for the first time, soak for 0.5 hours, then ultrasonically extract for 1 hour, and pour the extract into a container for later use. Continue to add 80L of 70v / v% ethanol to the dregs, soak for 0.5 hours, ultrasonically extract for 1 hour, pour out the extract and combine it with the first extract; depressurize the combined total extract to recover ethanol until it has no alcohol smell (vacuum degree -0.1MPa, temperature 75°C), the extract was diluted with distilled water to a volume of 25L, left to stand overnight, filtered, and the filtrate was set aside. The filtrate first passed through the treated AB-8 macroporous resin column at a flow rate of 2 times the column bed volume per hour, then eluted with 3 times the resin amount of pure water at a flow rate of 2 times the column bed volume per hour, and discarded the water for washing liquid, then elute the eff...

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Abstract

The invention belongs to the technical field of extraction and purification of traditional Chinese medicines, and particularly relates to a preparation method of extracts of effective fractions of lychee seeds. The method comprises the following steps of: (1) crushing the lychee seed medicinal material, adding ethanol and performing ultrasonic extraction; (2) recycling ethanol from the extract solution and diluting the extract with water, standing still and filtering; (3) adsorbing the filtrate by use of AB-8 macroporous resin, and eluting with water and ethanol later; (4) collecting the ethanol eluent, recycling ethanol and then concentrating to obtain thick paste; and (5) drying the extractum to obtain the extracts of the effective fractions of lychee seed. According to the invention, the extracts of the effective fractions, comprising the total flavones, total saponins and tannins of the lychee seeds are obtained at the same time by use of the sufficient extraction effect of ethanol on the effective components of the lychee seeds and the selection effect of the high-selectivity macroporous resin, and the total content of the total flavones, total saponins and tannins reaches over 70%; the process is simple and stable, and the quality is controllable; and the obtained extracts of the effective fractions of the lychee seeds conform to the requirements of the traditional Chinese medicine theory and the traditional Chinese medicine modernization.

Description

technical field [0001] The invention belongs to the technical field of extraction and purification of traditional Chinese medicines, and in particular relates to a preparation method of extracts of effective fractions of litchi kernels of traditional Chinese medicines. Background technique [0002] Lychee Seed, Litchi Seed, is the dry mature seed of Sapindaceae plant Litchi (Litchi Chinensis Sonn), also known as Li Ren, Li He, Da Li He, included in "Chinese Pharmacopoeia" 2010 edition one, Warm in nature, sweet in taste, slightly bitter, has the effects of promoting qi and dispelling stagnation, dispelling cold and relieving pain. "Compendium of Materia Medica" records that lychee core "quenches thirst, benefits people's color, and eats it to relieve polydipsia" (polydipsia, modern medicine is called diabetes). Studies have shown that lychee core has the functions of lowering blood sugar, regulating blood lipids, improving anti-oxidation, and inhibiting the surface antigen ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P29/00A61P3/10A61P3/06A61P3/00A61P31/12A61P35/00A61P5/50A61P39/06A61P37/04A61P1/16A61K131/00
Inventor 郭洁文钟世顺叶碧波
Owner GUANGZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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