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Oxaprozin and preparation technology thereof

A technology of oxaprozin and medicine, which is applied in the field of Chinese and Western medicine preparations for the treatment of rheumatoid arthritis, can solve the problems of repeated drug withdrawal and slow onset of action, and achieve good therapeutic effect

Active Publication Date: 2012-07-11
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of rheumatoid arthritis and other diseases, overcome the obvious shortcomings of a single oxaprozin, such as the slow onset of effect, and the easy and repeated withdrawal of the drug, so as to achieve the goal of treating both symptoms and root causes

Method used

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  • Oxaprozin and preparation technology thereof
  • Oxaprozin and preparation technology thereof
  • Oxaprozin and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A compound oxaprozin pharmaceutical composition is characterized in that it is prepared from the following weight ratio raw materials,

[0032] 25 parts of oxapuqin, 300 parts of Zhichuanwu, 260 parts of notopterygium, 165 parts of papaya, 100 parts of Eucommia

[0033] Wherein said Oxaprozin preparation method is:

[0034] 1. Feeding ratio

[0035]

[0036] 2. Production process

[0037] 2.1 Preparation of ethyl benzoin hemisuccinate: open a 200L reaction tank, add benzoin and succinic anhydride from the feeding port, and accurately suck in pyridine. Open the nitrogen inlet valve, feed nitrogen gas (into the tank with atmospheric air flow for 10 minutes first, and then use slow air flow to pass through the tank), start stirring, slowly raise the temperature to 92±1°C, start timing, and react for 1.5 hours.

[0038] 2,2 The preparation of oxaprozin: after the esterification reaction is finished, open the valve that enters glacial acetic acid, add 30kg

[0039] Gl...

Embodiment 2

[0048] 1. Clinical data

[0049] Clinical data: A total of 150 outpatients with complete medical records were selected. They were randomly divided into a treatment group of 80 cases and a control group of 70 cases. The age of the treatment group was 31-57 years old, with an average age of 40.5 years, and the course of disease was 2-10 years, with an average of 4.8 years; the age of the control group was 35-60 years old, with an average age of 41.3 years, with a course of disease of 2-13 years, with an average of 5.2 years. The course of the disease was tested by Chi-square test, and there was no statistically significant difference (p>0.05).

[0050] 2. Diagnostic criteria:

[0051] Diagnostic criteria of western medicine: refer to the diagnostic criteria of rheumatoid arthritis of the American College of Rheumatology in 1989: ①morning stiffness: stiffness in and around the joints lasts for at least 1 hour (duration ≥ 6 weeks); ②joints in 3 or more regional joints Inflammat...

Embodiment 3

[0059] typical embodiment

[0060] Na Mou, female, 47 years old, mainly due to swelling and pain of small joints of limbs for more than 2 years, aggravated in the past 1 month, severe limitation of activities, unable to make fists with both hands in the morning, and needs support from others when dressing and eating. He once took oxaprozin, meloxicam, ibuprofen and other medicines for treatment. The medication was discontinued due to gastrointestinal reactions. Examination: The proximal interphalangeal joints of both fingers were fusiformly swollen, the metacarpophalangeal joints and metatarsophalangeals were obviously painful, and functional activities were limited. Test ESR52mm / h, RF strong positive. X-ray films showed osteoporotic changes in the metacarpophalangeal and proximal interphalangeal joints, with rough articular surfaces and narrowed gaps. Diagnosis: rheumatoid arthritis. After taking the compound oxaprozin pharmaceutical composition prepared in Example 1 for ...

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Abstract

The invention relates to an oxaprozin and a preparation technology thereof. The oxaprozin is prepared from the following raw materials according to parts by weight: 25 parts of oxaprozin, 300 parts of prepared Sichuan aconite root, 260 parts of notopterygium root, 165 parts of pawpaw and 100 parts of the bark of eucommia. With the common medicine preparation method, a starch active edible cellulose medicinal auxiliary material is added to obtain dosage forms, such as capsules, tablets, granules and the like. The compound oxaprozin medicine composition disclosed by the invention treats both principal and secondary aspect of rheumatoid arthritis, is non-toxic and harmless to the human body, does not have side effect, has the advantages of low price and wide application prospect and is simple and convenient to manufacture.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Chinese and western medicine preparation for treating rheumatoid arthritis, in particular to the application of a medicine made of western medicine oxaprozin and Chinese herbal medicine in rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a disease mainly characterized by non-suppurative inflammation of joints and tissues around the joints, often accompanied by symptoms of extra-articular diseases, so it is called rheumatoid. It is a common frequently-occurring disease. Synovial inflammation in the joint cavity, exudate, cell proliferation, granuloma formation, cartilage and bone tissue destruction, and finally joint ankylosis and dysfunction. It mainly affects the joints and the heart, manifested as joint and muscle pain, numbness, swelling, red heat, and autoantibodies can be found in the serum, so it is considered that the disease is a...

Claims

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Application Information

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IPC IPC(8): A61K36/732A61K9/20A61P19/02A61P29/00A61K31/421
Inventor 赵振桥聂昌盛张玉美徐平田王丽娟杜宾芳
Owner 仁和堂药业有限公司
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