Method for crystallizing milrinone

A milrinone and crystallization technology, applied in the direction of organic chemistry, can solve problems such as unsatisfactory effects, achieve the effects of increased yield and purity, simple process, and solvent saving
CN102558044AInactive Publication Date: 2012-07-11方晏燕
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
方晏燕
Publication Date
2012-07-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for crystallizing milrinone without recrystallizing. A mixed solvent is used, and hot water is added to dimethyl formamide (DFM), thus the defects of multiple re-crystallization low crystal purity due to the utilization of signal solvent in the prior art are overcome. In the last step of subjecting materials to reaction to synthesize the milrinone, the crystallization is carried out to obtain the milrinone with a good crystal form, higher purity and higher yield, thus the operation and the reaction process are simplified, the pollution is reduced, and the cost is lowered. The milrinone is suitable for large-scale industrial production as the active pharmaceutical ingredient and meets the requirement of the injection preparation.
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Description

technical field

[0001] The application relates to a crystallization method of milrinone, which belongs to the crystallization method of specific drugs. Background technique

[0002] Milrinone (milrinone) is a drug for the treatment of heart failure, which can be used clinically for the treatment of heart failure patients with severe congestive heart failure or digitalis poisoning. Milrinone, as a non-digital and non-catecholamine cardiotonic drug, has both positive inotropic and vasodilation effects, because it can enhance myocardial contractility and increase cardiac output, while reducing cardiac load without Increase myocardial oxygen consumption, thereby improving cardiac function in patients with severe congestive heart failure or digitalis poisoning, and reducing dyspnea, cyanosis and pulmonary rales. In clinical applications, milrinone is generally used by intravenous injection, so as a drug that can be used as an emergency and administered intravenously, there are v...

Claims

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