Preparation method for EGCC phosphatide compound

A phospholipid complex and phospholipid technology, which can be used in food preparation, medical preparations with non-active ingredients, food science, etc., and can solve the problems of preparation and application of EGCG phospholipid complexes that have not been seen before.

Inactive Publication Date: 2012-07-18
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After literature search, there is no report about the preparation and application of EGCG phospholipid complex

Method used

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  • Preparation method for EGCC phosphatide compound
  • Preparation method for EGCC phosphatide compound
  • Preparation method for EGCC phosphatide compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 4.9 grams of soybean lecithin in a round-bottomed flask, add 100 milliliters of ethanol and stir to dissolve at room temperature, then gradually add 1 gram of EGCG while stirring, gradually raise the temperature to 40 ° C, and continue to stir and condense and reflux for 4 hours. Vacuum drying to obtain EGCG phospholipid complex products.

Embodiment 2

[0020] Dissolve 1 g of EGCG in 5 ml of ethanol. Another 1.8 grams of soybean lecithin was placed in a round bottom flask, and 35 milliliters of chloroform was added to dissolve at room temperature, then gradually added EGCG ethanol solution while stirring, and the temperature was gradually raised to 30°C, and the reaction was continuously stirred and condensed for 2 hours. Vacuum drying to obtain EGCG phospholipid complex products.

Embodiment 3

[0022] Dissolve 1 g of EGCG in 5 ml of ethanol. Another 3.4 grams of soybean lecithin was placed in a round-bottomed flask, and 70 milliliters of ethyl acetate was added to dissolve at room temperature, and then EGCG ethanol solution was gradually added while stirring, and the temperature was gradually raised to 40 ° C, and the reaction was continuously stirred and condensed for 3 hours. Vacuum drying to obtain EGCG phospholipid complex products.

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Abstract

The invention discloses a preparation method for an EGCC phosphatide compound. The EGCC phosphatide compound is prepared by compounding EGCC and phosphatide, wherein, the mol ratio of EGCC to phosphatide is 1: 1-3. The EGCC phosphatide compound prepared by using the method can effectively change physical and chemical properties of EGCC, maintain or enhance antioxidation performance of EGCC in different environments and improve bioavailability of EGCC, thereby enlarging application fields of EGCC.

Description

technical field [0001] The invention relates to a preparation method of epigallocatechin gallate phospholipid complex. Background technique [0002] Epigallocatechin gallate (EGCG) is an important monomer of catechins in tea, accounting for 80% of catechins. The pharmacological effects such as anti-cancer, anti-inflammation, anti-mutation, anti-aging and improving liver function have become the focus of catechin separation, purification and clinical application research. However, because EGCG has polyphenolic hydroxyl groups and is a highly polar substance, it is easily soluble in water and difficult to dissolve in oil, which limits its application in oils and other products and exerts a better physiological activity on human body. In addition, because EGCG has a strong bitter taste and poor stability during use, especially in an alkaline environment, it is easily oxidized and loses its unique antioxidant effect, which limits its use in food. of widespread use. Furthermor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/353A23L1/30A61P1/16A61P29/00A61P35/00A61P39/06
Inventor 曾晓雄雷时成胡冰续斐
Owner NANJING AGRICULTURAL UNIVERSITY
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