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Porous polysaccharide cell adsorption material as well as preparation method and application thereof

A technology of cell adsorption and polysaccharides, applied in chemical instruments and methods, absorbent pads, other chemical processes, etc., can solve the problems of high production cost, many toxic and side effects, complicated production process, etc., and achieve low price and simple preparation method , The effect of simple preparation process

Active Publication Date: 2012-07-18
TSINGHUA UNIV
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Problems solved by technology

[0003] In order to overcome the shortcomings of the existing hemostatic materials such as complex production process, high production cost and many side effects, the present invention provides a novel porous organic-inorganic hybrid polysaccharide cell adsorption material and its preparation method

Method used

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Embodiment

[0022] Example, Preparation of Porous Organic-Inorganic Hybrid Polysaccharide Cell Adsorption Material

[0023] 1. 3g chitosan is dissolved in the acetic acid solution of 97g 0.02g / ml, obtains the chitosan solution that mass concentration is 3%;

[0024] 2. Ethyl orthosilicate was hydrolyzed under acidic (pH value 3.5) conditions, stirred until the stratification disappeared, and 3ml of homogeneous aqueous solution (i.e. silica sol, wherein the mass content of silica was 21%;

[0025] 3. the aqueous solution (mass concentration 20%) of the polyethylene glycol of 1ml p-aldehyde benzoic acid end-blocking is mixed with the silica sol in step 2, then this mixed solution is mixed with chitosan solution, makes by stirring It mixes well.

[0026] 4. Aging the sol dispersed in the hydrogel (the aging condition is kept at a constant temperature of 50° C. for 24 hours). During the aging process, the silica sol undergoes polycondensation in situ to form a silica network scaffold.

[00...

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Abstract

The invention discloses a porous organic inorganic hybrid polysaccharide cell adsorption material as well as a preparation method and application thereof. The adsorption material provided by the invention is prepared through the method comprising the following steps: silicon dioxide collosol, chitosan solution and cross-linking agent water solution are mixed uniformly to obtain hydrogel, and the hydrogel is treated through seasoning and freeze drying in sequence to obtain the porous organic inorganic hybrid polysaccharide cell adsorption material, wherein cross-linking agent in the cross-linking agent water solution is aldehyde benzoic acid terminated polyethyleneglycol. According to the invention, the organic inorganic hybrid chitosan porous material taking a silicon dioxide network as the skeleton is formed in situ through a novel hydrogel preparation technology; and the material has favorable red blood cell adsorption capacity and is a potential admirable hemostatic material.

Description

technical field [0001] The invention relates to a porous polysaccharide cell adsorption material and its preparation method and application. Background technique [0002] At present, the hemostatic materials on the market are mainly divided into fibrin, polysaccharide and microporous zeolite. The hemostatic principle of hemostatic materials is mostly to increase the concentration of blood cells, platelets, and coagulation factors near the wound under the physical or chemical action of the material to form blood coagulation, so as to achieve the purpose of hemostasis. However, looking at the hemostatic materials currently on the market, there are problems such as complicated production process, high production cost, strict storage conditions (dry and low humidity), and some hemostatic materials will be accompanied by other side effects while achieving the purpose of hemostasis, such as microporous zeolite Hemostatic agents, in the process of blood coagulation, will be accomp...

Claims

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Application Information

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IPC IPC(8): B01J20/24B01J20/30A61L15/28A61L15/42
Inventor 危岩陶磊付长奎冯琳黎书樨
Owner TSINGHUA UNIV
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