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Aluminium adjuvant as well as preparation method and application thereof

An aluminum adjuvant and aluminum phosphate adjuvant technology, applied in chemical instruments and methods, pharmaceutical formulations, alumina/aluminum hydroxide, etc., can solve problems such as inhomogeneous product structure and unstable adjuvant performance, and achieve antibody titer high degree of effect

Inactive Publication Date: 2012-07-18
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the preparation method of aluminum adjuvant is mostly to add one of aluminum salt solution or alkaline solution to the other, and the structure of the product generated by this method is not uniform, and its adjuvant performance is not very stable.

Method used

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  • Aluminium adjuvant as well as preparation method and application thereof
  • Aluminium adjuvant as well as preparation method and application thereof
  • Aluminium adjuvant as well as preparation method and application thereof

Examples

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preparation example Construction

[0021] The invention provides a method for preparing an aluminum adjuvant, the method comprising contacting an aqueous solution of aluminum salt and / or phosphate with sodium hydroxide and / or ammonia solution, characterized in that the aluminum salt and / or phosphate The pH value of the whole process of contacting the aqueous solution with sodium hydroxide and / or ammonia solution is constant.

[0022] In the present invention, the constant pH value is a relative concept, that is, the above pH value can vary within a small range during actual operation, for example within ±0.1 range.

[0023] In the present invention, the mode of contacting the aqueous solution of the aluminum salt and / or phosphate with sodium hydroxide and / or ammonia solution is not particularly limited, as long as the aqueous solution of the aluminum salt and / or phosphate is mixed with hydrogen The pH value of the whole process of sodium oxide and / or ammonia solution contacting can be constant. For example, th...

Embodiment 1

[0046] Weigh a certain amount of AlCl 3 ·6H 2 O, dissolved in distilled water, and prepared into an aqueous solution with an aluminum ion concentration of 0.05 mol / L; weigh a certain amount of NaOH, dissolve it in distilled water, and obtain a 0.5 mol / L NaOH aqueous solution. Using a peristaltic pump, the AlCl 3 ·6H 2 O solution and NaOH solution were pumped into the bottom of the 2L reactor, stirred, AlCl 3 ·6H 2 The flow rate of O is 50ml / min, the flow rate of NaOH solution is 15ml / min, the pH value of the reaction solution in the reactor is controlled at 10±0.1, and the reaction temperature is 25°C. When the aqueous solution passed into the reactor is full of overflow, the suspension is discharged from the overflow port into the receiving tank. After discarding the initial 2L of suspension, collect the suspension, and after standing for 5 hours, discard the supernatant solution, centrifuged to obtain a precipitate, and washed 3 times with distilled water. The precipit...

Embodiment 2

[0048] Weigh a certain amount of aluminum sulfate, dissolve it in distilled water, and prepare an aqueous solution with an aluminum ion concentration of 0.025mol / L; weigh a certain amount of NaOH, dissolve it in distilled water, and obtain a 0.21mol / L NaOH aqueous solution. Using a peristaltic pump, the AlCl 3 ·6H 2 O solution and NaOH solution were pumped into the bottom of the 2L reactor, stirred, AlCl 3 ·6H 2 The flow rate of O is 100ml / min, the flow rate of NaOH solution is 30ml / min, the pH value of the reaction solution in the reactor is controlled at 9.5±0.1, and the reaction temperature is 25°C. When the aqueous solution passed through filled the reactor, it began to overflow, and the suspension was discharged from the overflow port into the receiving tank. After discarding the initial 1L suspension, the suspension was collected, and after standing for 5 hours, the supernatant was discarded. , and centrifuged to obtain a precipitate, which was washed 3 times with dis...

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Abstract

The invention provides a preparation method of an aluminium adjuvant. The method comprises the step that water solution of aluminium salt and / or phosphate is contacted with water solution of sodium hydroxide and / or ammonia, and is characterized in that the pH value is constant during the whole process that the water solution of aluminium salt and / or phosphate is contacted with the water solution of sodium hydroxide and / or ammonia. The invention further provides an aluminium adjuvant obtained through the preparation method and the application of the aluminium adjuvant on vaccine. The preparation method of aluminium adjuvant has the advantage that the obtained product is uniform in structure, stable in property and reliable in quality; and the aluminium adjuvant prepared through the method can adsorb more vaccine.

Description

technical field [0001] The invention relates to a preparation method of an aluminum adjuvant, the aluminum adjuvant and the application of the aluminum adjuvant in vaccines. Background technique [0002] Aluminum adjuvants are a class of Al-containing 3+ Aluminum hydroxide and aluminum phosphate adjuvants are the most commonly used and effective. Aluminum salt adjuvants are the earliest adjuvants approved by the U.S. Food and Drug Administration (FDA) for human vaccines. They are low in preparation cost and easy to use, and are the most widely used adjuvants in vaccine production. The mechanism of action of the aluminum adjuvant: form a complex with the antigen, form an antigen storage pool in the tissue after injection, make the antigen release slowly, stimulate immune cells for a long time, and enhance the immune response of the body. Aluminum adjuvant is currently the most important vaccine adjuvant. Since Glenny first applied aluminum salt to adsorb diphtheria toxoid i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F7/02C01B25/36A61K39/39B82Y40/00B82Y30/00
Inventor 梁兴杰贲虎钱峰
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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