Externally applied medicine composition for treating common acne

A technology for topical drugs and acne vulgaris, applied in drug combinations, pharmaceutical formulas, medical preparations with non-active ingredients, etc., can solve problems such as low solubility, easy precipitation of crystals, and influence on curative effect, and achieve good effects, good stability, The effect of enhancing the efficacy of the drug

Active Publication Date: 2012-07-25
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, Chinese patent CN 1210041C discloses a compound preparation for external use of tazarotene and antibacterial drugs, but general ointment preparations often require high-speed homogenization to obtain a cream with uniform particle size distribution and fineness. In addition, tazarotene The solubility in water is low, and crystals are easy to precipitate during long-term storage, which affects the curative effect. Therefore, the 2005 edition of Pharmacopoeia adds the requirement for particle size inspection to creams

Method used

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  • Externally applied medicine composition for treating common acne
  • Externally applied medicine composition for treating common acne

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Compound Tazarotene Clindamycin Cream

[0061] Table 1 Prescription Form of Compound Tazarotene Clindamycin Cream

[0062] name Quantity, g / 100g Tazarotene 0.05 clindamycin phosphate 1.19 Polyoxyl(40) Stearate 3.5 liquid paraffin 7.0 White Vaseline 8.0 cetyl alcohol 5.0 Glyceryl monostearate 3.5 Span 60 2.0 Tween 80 2.0 glycerin 7.0 Edetate Disodium 0.1 Benzyl alcohol 1.0 Triethylamine Adjust the pH of the aqueous phase to 5.5 purified water up to 100g

[0063] Preparation process: Take polyoxyl (40) stearate and heat to 80°C to melt, add tazarotene to dissolve; take oil phase base liquid paraffin, white petrolatum, cetyl alcohol, Span 60, and melt at 80°C ; Mix the two solutions to obtain an oil phase solution. Separately take clindamycin phosphate, Tween 80, glycerin, edetate disodium, benzyl alcohol and add purified water to dissolve, adjust the pH value t...

Embodiment 2

[0065] Example 2: Compound Tazarotene Clindamycin Cream

[0066] Table 2 Prescription Form of Compound Tazarotene Clindamycin Cream

[0067] name Quantity, g / 100g Tazarotene 0.03 clindamycin phosphate 1.19 Polyoxyl(40) Stearate 3.5 liquid paraffin 7.0 White Vaseline 8.0 cetyl alcohol 5.0 Glyceryl monostearate 3.5 Span 60 2.0 Tween 80 2.0 glycerin 7.0 Edetate Disodium 0.1 Benzyl alcohol 1.0 Triethylamine Adjust the pH of the aqueous phase to 5.5 purified water up to 100g

[0068] Preparation process: Take polyoxyl (40) stearate and heat to 80°C to melt, add tazarotene to dissolve; take oil phase base liquid paraffin, white petrolatum, cetyl alcohol, Span 60, and melt at 80°C ; Mix the two solutions to obtain an oil phase solution. Separately take clindamycin phosphate, Tween 80, glycerin, edetate disodium, benzyl alcohol and add purified water to dissolve, adjust the pH value t...

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Abstract

The invention provides an externally applied medicine composition for treating common acne, which contains a novel retinoic acid medicine selectively developed for a receptor as a first pharmacological active ingredient A, an antibacterial agent as a second pharmacological active ingredient B, and either polyoxyl (40) stearate or polyoxyl (15) stearate as a solvent component C. Compared with an ordinary cream, the cream containing the solvent component C is easier to uniformly emulsify in the preparation process; furthermore, the physical characteristics of the cream in the storing process are more stable; in addition, the compatibility between a medicament and the skin is increased via the solvent component C in the using process, the contact between the medicine and focus parts is increased, and the medicinal cure effect is increased.

Description

technical field [0001] The invention relates to an external pharmaceutical composition for treating acne vulgaris. Background technique [0002] Acne vulgaris (hereinafter referred to as acne) is a chronic inflammatory skin disease that occurs in the pilosebaceous glands. The pathogenesis of this disease is not fully understood, and the currently recognized pathogenesis includes the following four pathogenesis links. 1. Hyperkeratosis of the follicular infundibulum; 2. Androgen and sebaceous gland hyperfunction; 3. The role of microorganisms in the pilosebaceous unit (Propionibacterium acnes is the most closely related to acne); 4. Inflammation and the immune response of the host. After acne forms, it can be roughly divided into three grades according to the skin lesion situation, mild, moderate and severe acne. At present, all drug treatments are theoretically carried out through the intervention of the above four links. Combination therapy is currently the standard ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/4436A61K9/06A61K47/34A61P17/10
Inventor 付劼周海滨张新明
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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