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Compound salicylic acid and clotrimazole aerosol

A compound salazole and aerosol technology, which can be used in aerosol delivery, antifungal agents, pharmaceutical formulations, etc., can solve problems such as the destruction of the atmospheric ozone layer, and achieve good safety performance, stable drug quality, social value and economic value. significant effect

Inactive Publication Date: 2012-08-08
GUIZHOU JINGCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Freon (F 12 ) has a destructive effect on the atmospheric ozone layer

Method used

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  • Compound salicylic acid and clotrimazole aerosol

Examples

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Effect test

Embodiment Construction

[0013] Embodiment of the present invention: its formula raw material comprises salicylic acid, clotrimazole, phenol, camphor, winter green oil, glycerin, ethanol, and propellant adopts fluoroalkane tetrafluoroethane. The volume ratio or weight ratio of the propellant to formula raw materials is 1:1.

[0014] The recipe ingredients for making are:

[0015] Salicylic acid 50g

[0016] Clotrimazole 10g

[0017] Phenol 5g

[0018] Camphor 10g

[0019] Oil of wintergreen 10g

[0020] Glycerin 100g

[0021] Proper amount of ethanol

[0022] Made 1000m1

[0023] The production method is as follows: take the crude drug according to the above proportion, stir and dissolve, adjust the total amount to 1000ml with 90% ethanol,

[0024] Mix evenly, put 25ml of liquid medicine in each bottle, press into the propellant to make the total weight 50g or put 15ml of liquid medicine in each bottle, press in the propellant to make the total weight to 30g, seal it, and get it.

...

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PUM

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Abstract

The invention discloses a compound salicylic acid and clotrimazole aerosol. Formula raw materials of the aerosol comprise salicylic acid, clotrimazole, phenol, camphor, methyl salicylate, glycerin, and ethanol, and a propellent adopts a hydrofluoroalkane of tetrafluoroethane or heptafluoropropane (HFA227), dimethyl ether (DME), a hydrocarbon or a compressed gas. The volume or weight ratio of the propellent to the formula raw materials is 1:1. The aerosol which uses HFA134a to substitute F-12 as the propellent can avoid the destroy to the atmospheric ozone layer, can realize energy saving and consumption reduction in the medicinal preparation process, and has substantial economic benefits.

Description

technical field [0001] The present invention relates to a kind of compound recipe salicidazole aerosol. Background technique [0002] "Compound Sudazole Aerosol" is used for tinea corporis and tinea manus and pedis, etc. caused by fungi, and is a two-phase aerosol for external use. It consists of liquid medicine, propellant, pressure-resistant container and valve system. The drug has good curative effect, is convenient and safe to use, has been praised by patients, and has a good market. However, Freon (F 12 ) has a destructive effect on the atmospheric ozone layer. [0003] In order to protect the ozone layer, in March 1985, government representatives of 21 countries signed the "Vienna Convention for the Protection of the Ozone Layer" in Vienna, marking the beginning of an international unified action for the protection of the ozone layer. The "Convention" came into force in September 1989. In September 1987, 24 countries signed the "Montreal Protocol on Substances tha...

Claims

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Application Information

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IPC IPC(8): A61K31/618A61K31/60A61K31/4174A61K31/125A61K9/12A61P31/10A61P17/00
Inventor 徐和石松罗琳栋
Owner GUIZHOU JINGCHENG PHARMA
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