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Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent

An artificial bile duct and double-layer composite technology, which is applied in the human tubular structure device, medical science, prosthesis, etc., can solve the problems of threatening the life of patients, bile leakage, and inability to effectively support bile flow, so as to avoid secondary surgery , prevent bile leakage, good clinical application prospects

Inactive Publication Date: 2014-12-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the porous structure of the tissue-engineered bile duct stent, it cannot effectively support the flow of bile before the bile duct tissue is formed, and there is a risk of bile leakage, which greatly threatens the life of the patient

Method used

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  • Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent
  • Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent
  • Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0026] 1) Apply a polyester solution with a comparative mass concentration of 15%on a glass rod with a diameter of 5.5mm. Release it and remove it from the glass rod to obtain a dense membrane polycophactone tube.

[0027] 2) The dense membrane -shaped polycophactone tube is made in step 1 as an internal tube, and the outer diameter of the outer diameter of the outer axis is 7.5 mm.The gelatin particles with a particle size of 280 μm, and then injected into a ethanol solution with a volume of 85%, infiltrate the gelatin particles, and the temperature is 70 o C's oven, after the glue particles are bonded, removed, in -25 o C, freezing, freezing and drying at the temperature of C, removing the glass external tube, obtained the inner layer as a polycophactone tube, and the outer layer is a composite tube of the gelatin particle adhesive layer.

[0028] 3) Soak the composite tube of step 2) in a polyester solution with a mass concentration of 10%for 0.5 minutes. After removing o Froze...

example 2

[0032] 1) Painting the mass concentration of 15%(lactic acid-ethanol acid) co-solution on the glass rod with a diameter of 2 mm, dry it, remove it from the glass rod to get the dense membrane polymer (lactic acid-Etheric acid) Co -concentration.

[0033] 2) The dense membrane-shaped agglomeration (lactic acid-ethanol) co-pipe is used as an internal tube with step 1). The outer diameter of the outer diameter of the coaxial coaxial rays is 6 mm.) Fill the gelatin particles with a particle size of 450 μm between the co -concentration tubes and the glass tube, and then inject the ethanol solution with a volume concentration of 85%, infiltrate the gelatin particles, put the temperature in 70 at 70 o C's oven, after the glue particles are bonded, removed, in -25 o C freezes, freezing and drying at the temperature, remove the glass outer tube, obtain the inner layer (lactic acid-ethanol acid) co-concentration tube, and the outer layer is a composite tube of the gelatin particle bonding l...

example 3

[0036] 1) Apply a polysile -aternal solution with a mass concentration of 15%on the glass rod with a diameter of 1mm. Release it and remove it from the glass rod to obtain the dense membrane polycophactone tube.

[0037] 2) The dense membrane -shaped polycophactone tube is made by step 1, and the outer diameter of the outer diameter of 3 mm is placed in the outer axis of the outer axis.The gelatin particles with a particle size of 250 μm, and then injected into a ethanol solution with a volume of 85%, infiltrate the gelatin particles, and the temperature is 70 o C's oven, after the glue particles are bonded, removed, in -25 oC, freezing, freezing and drying at the temperature of C, removing the glass external tube, obtained the inner layer as a polycophactone tube, and the outer layer is a composite tube of the gelatin particle adhesive layer.

[0038] 3) The composite tube of step 2) is soaked in a cluster (lactic acid-ethanol) with a mass concentration of 8%in the mass concentra...

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Abstract

The invention discloses an artificial bile duct bionic stent with a double-layered compound structure and a preparation method of the artificial bile duct bionic stent. The preparation method includes using biodegradable polyester as raw materials; preparing a compact membrane-shaped inner duct by a coating method; preparing a polyester outer duct with a communicated porous structure by a gelatin porogen method; and compounding the outer duct with the inner duct so as to obtain the artificial bile duct bionic stent with the double-layered compound structure. Repeatability of a preparation process is good. The inner duct of the artificial bile duct bionic stent can support bile circulation and prevent bile leakage, and the outer duct can support cell growth and regeneration to form new bile duct tissues. The artificial bile duct bionic stent is fine in biocompatibility, free of cytotoxicity and capable of realizing regeneration and repair of a bile duct, avoids secondary surgery, can be used for tissue engineering bile duct construction and bile duct coloboma repair, and has a good clinical application prospect.

Description

Technical field [0001] The present invention involves the construction of porous brackets for organizational engineering, especially a method of degradable polyester. The method of artificial biliary bionic stent with a double -layer composite structure through the coating method and gelatin pores. Background technique [0002] Organizational projects are cross -research topics involving multi -disciplinary and multi -fields involving medical, chemistry, biology, and material science.In the research of organizational engineering, the selection of bracket materials and the construction of brackets are the key links.Only by constructing a stand with specific micro -structure, excellent mechanical performance, suitable degradation performance, and good biocompatibility, can we effectively promote the adhesion and growth of cells, and then guide the regeneration of tissue and organs.Polyester can be completely degraded in the organism. The product after degradation is carbon dioxide ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/04A61L27/18A61L27/56
Inventor 马列王美聪董洁王千千高长有
Owner ZHEJIANG UNIV
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