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Vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea and preparation method thereof

A technology of Sophora flavescens green tea and effervescent tablet, applied in Sophora flavescens green tea vagina effervescent tablet and preparation thereof, Sophora flavescens green tea vaginal effervescent tablet, preparation of medicines for preventing and treating cervical intraepithelial neoplasia of women, preparation of Sophora flavescens green tea In the field of vaginal effervescent tablets, it can solve problems that need to be strengthened

Active Publication Date: 2014-02-19
WUHAN HUADA PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current research on drugs for the treatment of cervical precancerous lesions caused by HPV infection, especially for the treatment of cervical erosion and mild and moderate cervical dysplasia caused by HPV infection, still needs to be strengthened

Method used

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  • Vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea and preparation method thereof
  • Vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea and preparation method thereof
  • Vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1. Selection of auxiliary materials and preparation process of Sophora flavescens green tea vaginal effervescent tablet

[0073] Prepare the Sophora flavescens extract used in the examples of the present invention according to the following steps, set aside: 360 grams of Sophora flavescens, boil 3 times with 8 times the amount of water, each time for 1 hour, so as to obtain the Sophora flavescens extract, and then combine Extract the liquid and filter it, and concentrate the filtrate to a concentrated liquid with a relative density of 1.06-1.08 (50°C). Then add hydrochloric acid to adjust the pH value to 3-4, filter, and pass the supernatant through a 732-type cation exchange resin column, wash away some impurities with 10 times the resin volume of water and 6 times the resin volume of 30% ethanol, and then wash with 1 times the resin volume Resin volume concentrated ammonia water alkalized the resin, then eluted with 30% ethanol 6 times the volume of the resin,...

Embodiment 2

[0148] Embodiment 2, preparation of sophora flavescens green tea vaginal effervescent tablet

[0149] 1) Prescription:

[0150]

[0151] 2) Preparation method:

[0152] a. Weigh 2450g of Sophora flavescens in the prescribed amount, and boil 3 times with 8 times the amount of water, each time for 1 hour. Combine the extracts and concentrate to a concentrated solution with a relative density of 1.06-1.08 (50°C). Add hydrochloric acid to adjust the pH value to 3-4, filter, and pass the supernatant through a 732-type cation exchange resin column, wash away some impurities with 10 times the resin volume of water and 6 times the resin volume of 30% ethanol, and then wash with 1 times the resin volume The resin was basified with concentrated ammonia water, and eluted with 6 times the volume of the resin with 30% ethanol. The eluate was concentrated under reduced pressure, dried, and pulverized to obtain a fine powder of Sophora flavescens extract.

[0153] b. Weigh the prescri...

Embodiment 3

[0158] Embodiment 3, preparation of sophora flavescens green tea vaginal effervescent tablet

[0159] 1) Prescription:

[0160]

[0161] 2) Preparation method:

[0162] a. The preparation method of Sophora flavescens extract and green tea extract and the pretreatment method of each raw material are the same as in Example 2;

[0163] b. Filter Sophora flavescens extract, green tea extract and other auxiliary materials through a 160-mesh sieve, and dissolve povidone K30 in absolute ethanol to prepare a 5% povidone K30 absolute ethanol solution for later use.

[0164]c. After mixing green tea extract with 160g of tartaric acid, 40g of palmitic acid stearate, and 140g of lactose, wet the soft material with an appropriate amount of 5% povidone K30 absolute ethanol solution, and granulate with a 20-mesh sieve; wet granules Air-dried at 45°C for 1.5 hours, sieved with a 16-mesh sieve; set aside.

[0165] d. Mix Sophora flavescens extract with 24g of sodium carbonate, 136g of so...

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Abstract

The invention provides a vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea and a preparation method thereof. The vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea contains radix sophorae flavescentis extract, green tea extract, a surface active agent, an effervescing agent, a filler, a binding agent, a disintegrating agent and a lubricating agent, wherein the radix sophorae flavescentis extract is water extract of radix sophorae flavescentis, and the green extract is ethanol extract of green tea. The vaginal effervescent tablet prepared from radix sophorae flavescentis and green tea has good preventing and treating effects on cervical intraepithelial neoplasia.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to Sophora flavescens green tea vaginal effervescent tablet and a preparation method thereof. More specifically, the present invention provides a Sophora flavescens green tea vaginal effervescent tablet, a method for preparing Sophora flavescens green tea vaginal effervescent tablet, and Sophora flavescens green tea vaginal effervescent tablet for preventing and treating female cervical intraepithelial neoplasia Uses in medicine. Background technique [0002] Cervical intraepithelial neoplasia (CIN) is included in the generalized cervical lesions, which refers to cervical atypical hyperplasia and carcinoma in situ, the so-called cervical precancerous lesions, reflecting the continuous process of cervical cancer development. According to the degree of cell abnormality, CIN is divided into 3 grades: CIN I, CIN II, and CIN III. CIN I is equivalent to mild dysplasia, and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K36/82A61P31/20A61K36/489
Inventor 黄璐张思佳陈顺钦牟峰汪建
Owner WUHAN HUADA PHARMA