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Eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin

The technology of body gel and baicalin is applied in the preparation of the gel preparation, and the pH-sensitive baicalin eye is used in the field of body gel preparation, which can solve the problems of low bioavailability, loss of baicalin and the like, and achieves the composition of Reasonable, solve the effect of excessive metabolism and improve bioavailability

Active Publication Date: 2012-08-29
北京汇诚瑞祥医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the shortcomings of the dosage form of eye drops and the physical and chemical properties of baicalin itself at different pH values, most of the baicalin instilled into the eyes is lost, and the bioavailability is low

Method used

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  • Eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin
  • Eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin
  • Eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation of Example 1pH Sensitive Baicalin Ophthalmic In-body Gel (1)

[0049] The composition of the drug prescription is: 0.1 part of baicalin, 0.3 part of carbomer 974P NF 974P NF), 0.6 parts of HPMC E4M, 0.9 parts of sodium chloride, 0.001 parts of benzalkonium bromide, and 94 parts of phosphate buffered saline (PBS) at pH 5.8.

[0050] The preparation method of the above-mentioned pH-sensitive ophthalmic in-body gel preparation comprises the following steps:

[0051] (1) preparation matrix: get the described ratio Add an appropriate amount of pH5.8 phosphate buffer with HPMC E4M under continuous stirring, and stir evenly to obtain the matrix;

[0052] (2) Prepare the drug solution: take the baicalin, sodium chloride and benzalkonium bromide in the ratio, gradually add them to the phosphate buffer solution with pH 5.8, and mix evenly to obtain the drug solution;

[0053] (3) Mixing: Add the drug solution prepared in step (2) into the matrix obtained in step ...

Embodiment 2

[0054] Preparation of embodiment 2pH-sensitive baicalin ophthalmic in-body gel (2)

[0055] The composition of the drug prescription is: 0.1 part of baicalin, 0.3 part 980NF, 0.6 parts of HPMC F4M, 0.9 parts of sodium chloride, 0.001 parts of benzalkonium bromide, and 94 parts of phosphate buffer at pH 5.8.

[0056] The preparation method of the pH-sensitive ophthalmic in-body gel preparation is the same as that in Example 1.

Embodiment 3

[0057] Preparation of Example 3 pH Sensitive Baicalin Ophthalmic In-body Gel (3)

[0058] The composition of the drug prescription is: 0.1 part of baicalin, 0.3 part 934P NF, 0.6 parts of HPMC K4M, 0.9 parts of sodium chloride, 0.001 parts of benzalkonium bromide, and 94 parts of phosphate buffer at pH 5.8.

[0059] The preparation method of the pH-sensitive ophthalmic in-body gel preparation is the same as that in Example 1.

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Abstract

The invention relates to an eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin, which comprises the following components in parts by weight: 0.05-10 parts of baicalin, 0.1-3 parts of pH sensitive material, 0.1-10 parts of thickening agent, 0.1-10 parts of isoosmotic adjusting agent, 0.001-3 parts of preservative and 80-100 parts of buffer solution of which the pH is 5-6.2. The invention also relates to a preparation method for the eye-purposed in-vivo gel preparation prepared from the pH sensitive type baicalin, and the application of the eye-purposed in-vivo gel preparation prepared from the pH sensitive type baicalin in preparing drugs capable of preventing and / or curing conjunctivitis, keratitis or cataract.

Description

technical field [0001] The present invention relates to an ophthalmic pharmaceutical preparation, in particular to an ophthalmic in-body gel preparation, especially a pH-sensitive baicalin ophthalmic in-body gel preparation, and the preparation method and application of the gel preparation . Background technique [0002] The traditional ophthalmic drug delivery method is often in the form of eye drops, but eye drops have problems such as short residence time and low bioavailability. Degrees are generally less than 10%. Therefore, the inherent deficiency of ophthalmic liquid preparations has prompted people to explore the development of ocular solid drug delivery systems with long residence time and slow and controlled release capabilities. Environmentally sensitive gel drug delivery system is a new dosage form born with the rapid development of pharmaceutical polymer material science, which improves patient compliance. Environmentally sensitive gel refers to a non-chemica...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/7048A61K47/32A61K47/36A61K47/38A61P27/02A61P27/12
Inventor 刘志东武昊昀李琳李楠李佳玮
Owner 北京汇诚瑞祥医药生物科技有限公司
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