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Child cefalexin composition

A technology of ampicillin composition and cephalosporin, which is applied in the directions of inactive components of polymer compounds, pill delivery, antibacterial drugs, etc., can solve the problems of low bioavailability, difficult swallowing by patients, inconvenient taking, etc., and achieves high safety. , Shorten freeze-drying time, no gritty effect

Active Publication Date: 2012-08-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tablets are pressurized, disintegrate slowly, have low bioavailability, and are difficult for some patients to swallow, especially for children.

Method used

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  • Child cefalexin composition
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  • Child cefalexin composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Prepare 75mg / tablet cephalexin composition freeze-dried orally disintegrating tablets for children,

[0046] Prescription: 1000 tablets

[0047]

[0048]

[0049] Preparation Process:

[0050]Dissolve the cephalexin of prescription quantity in the tert-butanol (solution a) of prescription quantity, stir and dissolve at normal temperature, continue to stir, the mannitol of prescription quantity, sucralose are dissolved in prescription and use purified water total amount 70% -80% purified water (solution b); then dissolve the prescribed amount of gelatin in purified water (solution c) with a prescribed water consumption of 20%-30%, and heat until completely dissolved; combine the above two solutions of b and c Form solution d, and stir evenly, and then cool the mixed solution to below 5°C. Mix the two solutions a and d, stir well, and adjust the pH value to 6.0-6.5 with sodium bicarbonate. According to the specifications of the freeze-dried orally disintegrating ...

Embodiment 2

[0052] Prepare 75mg / tablet cephalexin composition freeze-dried orally disintegrating tablets for children,

[0053] Prescription: 1000 tablets

[0054]

[0055] Preparation Process:

[0056] Dissolve the cephalexin of prescription quantity in the tert-butanol (solution a) of prescription quantity, stir and dissolve at normal temperature, continue to stir, the mannitol of prescription quantity, sucralose are dissolved in prescription and use purified water total amount 70% -80% purified water (solution b); then dissolve the prescribed amount of gelatin in purified water (solution c) with a prescribed water consumption of 20%-30%, and heat until completely dissolved; combine the above two solutions of b and c Form solution d, and stir evenly, and then cool the mixed solution to below 5°C. Mix the two solutions a and d, stir well, and adjust the pH value to 6.0-6.5 with sodium bicarbonate. According to the specifications of the freeze-dried orally disintegrating tablets of ...

Embodiment 3

[0058] Prepare 75mg / tablet cephalexin composition freeze-dried orally disintegrating tablets for children,

[0059] Prescription: 1000 tablets

[0060]

[0061] Preparation Process:

[0062] Dissolve the cephalexin of prescription quantity in the tert-butanol (solution a) of prescription quantity, stir and dissolve at normal temperature, continue to stir, the mannitol of prescription quantity, sucralose are dissolved in prescription and use purified water total amount 70% -80% purified water (solution b); then dissolve the prescribed amount of gelatin in purified water (solution c) with a prescribed water consumption of 20%-30%, and heat until completely dissolved; combine the above two solutions of b and c Form solution d, and stir evenly, and then cool the mixed solution to about 5°C. Mix the two solutions a and d, stir well, and adjust the pH value to 6.0-6.5 with sodium bicarbonate. According to the specifications of the freeze-dried orally disintegrating tablets of ...

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PUM

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Abstract

The invention discloses a child cefalexin composition, which relates to the technical field of medicinal preparations. A prescription of the composition consists of the following components in percentage by weight: 25 percent of cephalexin, 25-75 percent of mannitol, 2-4 percent of gelatin and 0.1-0.15 percent of sucralose. The invention further provides a child cefalexin composition freeze-driven oral disintegrated tablet containing the child cefalexin composition. The freeze-driven oral disintegrated tablet has the advantages of simple composition, no need of water for taking, no need of chewing, disintegration time of not more than 2 seconds in the oral cavity of a human being, quick response, small residues in intestinal canals, full absorption, small side effects, good mouthfeel and particular suitability for infant patients.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pediatric cephalexin composition and a pediatric cephalexin composition freeze-dried orally disintegrating tablet made from the composition and a preparation method thereof. Background technique [0002] Cephalexin is suitable for most strains of Streptococcus pneumoniae, Streptococcus hemolyticus, Staphylococcus penicillinase-producing or non-producing, and most strains are sensitive to this product. This product has good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; this product has certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis all showed resistance to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-po...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/42A61P31/04
Inventor 李祖红汪六一汪金灿
Owner HAINAN WEI KANG PHARMA QIANSHAN
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