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Kuh-seng and green tea suppository and preparation method thereof

The technology of Sophora flavescens green tea and Sophora flavescens is applied in the directions of suppository delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems that need to be strengthened.

Inactive Publication Date: 2012-09-05
WUHAN HUADA PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current research on drugs for the treatment of cervical precancerous lesions caused by HPV infection, especially for the treatment of cervical erosion and mild and moderate cervical dysplasia caused by HPV infection, still needs to be strengthened

Method used

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  • Kuh-seng and green tea suppository and preparation method thereof
  • Kuh-seng and green tea suppository and preparation method thereof
  • Kuh-seng and green tea suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1, preparation of Sophora flavescens extract, green tea extract

[0070] Preparation of Sophora flavescens extract:

[0071] Weigh the Sophora flavescens of the prescribed amount, add 8 times the volume of water each time, decoct 3 times for 1 hour each time, so as to obtain the Sophora flavescens extract, then combine the extract and filter it, and concentrate the filtrate to a relative density of 1.07 (50°C) concentrate. Then add hydrochloric acid to adjust the pH value to 3.5, filter, and pass the supernatant through a 732-type cation exchange resin column, remove impurities with water 10 times the volume of the resin and 30% ethanol 6 times the volume of the resin, and then use 1 times the volume of the resin to concentrate Ammonia water alkalized the resin, and then eluted with 6 times the volume of the resin with 30% ethanol, concentrated the eluate under reduced pressure, dried under reduced pressure, and pulverized to obtain a fine powder of Sophora ...

Embodiment 2

[0074] Embodiment 2, the preparation of sophora flavescens green tea suppository

[0075] Utilize the sophora flavescens extract and the green tea extract that the preparation of embodiment 1 obtains to carry out following experiment, so that the preparation technology of sophora flavescens green tea suppository is researched:

[0076] 1. Screening of suppository base

[0077] The suppository base is the key to suppository molding. The selected base must meet the requirements of easy mixing of drugs, injection molding, molding, good appearance of the finished suppository, and compliance with the pharmacopoeia for the melting time limit. Sophora flavescens extract and green tea extract are both water-soluble, so this experiment chooses oily base as the suppository base of Sophora flavescens and green tea suppository. Specifically, this test takes the appearance of the suppository, the melting time limit, the dissolution rate of matrine and oxymatrine in 1 hour, and the dissolu...

Embodiment 3

[0112] Embodiment 3, the preparation of sophora flavescens green tea suppository

[0113] 1) Prescription:

[0114]

[0115]

[0116] 2) Preparation method:

[0117] a. According to the method for preparing Sophora flavescens extract described in Example 1, 2400 g of Sophora flavescens was prepared as Sophora flavescens extract.

[0118] b. According to the method for preparing a green tea extract described in Example 1, 800 g of green tea is prepared into a green tea extract.

[0119] c. After dissolving the Sophora flavescens extract with 0.1mol / L hydrochloric acid solution, add 80g of lanolin and mix well to obtain the Sophora flavescens extract mixture; 250g of propylene glycol monostearate and 500g of 38 type mixed fatty acid glycerides in Heat and melt in a water bath at 50°C, mix evenly, and slowly drop into the above-mentioned Sophora flavescens extract mixture, stir and disperse evenly, so as to obtain a Sophora flavescens extract composition; after dissolving...

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Abstract

The invention provides a kuh-seng and green tea suppository and a preparation method thereof. The kuh-seng and green tea suppository contains kuh-seng extract which is water extract of kuh-seng, green tea extract which is ethanol extract of green tea, and suppository base. The kuh-seng and green tea suppository has the advantages of good appearance, high medicinal dissolution, high stability, strong anticorrosion capability and good sterilization effect, the dissolving time limit of the suppository meets the requirement, and the pH value of the suppository is close to that of vagina.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a sophora flavescens green tea suppository and a preparation method thereof. More specifically, the present invention provides a Sophora flavescens green tea suppository, a method for preparing the Sophora flavescens green tea suppository and the use of the Sophora flavescens green tea suppository in the preparation of medicaments for preventing and treating cervical intraepithelial neoplasia in women. Background technique [0002] Cervical intraepithelial neoplasia (CIN) is included in the generalized cervical lesions, which refers to cervical atypical hyperplasia and carcinoma in situ, the so-called cervical precancerous lesions, reflecting the continuous process of cervical cancer development. According to the degree of cell abnormality, CIN is divided into three grades: CIN I, CIN II, and CIN III. CIN I is equivalent to mild dysplasia, and the abnormal proliferati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/02A61P15/00
Inventor 张思佳黄璐牟峰陈顺钦汪建
Owner WUHAN HUADA PHARMA