The invention discloses a rapid desulfurization refining method for a ladle furnace (LF). The method comprises the following steps of: 1) performing desulfurization refining in the LF, wherein the LF treatment starting temperature is between 1,570 and 1,605 DEG C; 2) after a ladle argon blowing device of the LF is turned on, blowing argon from the bottom of the ladle; 3) after finishing adjusting the temperature, inserting a desulfurization powder spraying gun into a molten steel liquid for spraying a desulfurizing agent; 4) after finishing spraying powder, switching the spraying gun to a functional stage of blowing the argon, blowing the argon from the top, simultaneously blowing the argon from the bottom of the ladle, and performing strong stirring desulfurization operation; 5) alloying, namely after desulfurization is finished, lifting the desulfurization powder spraying gun, adjusting a ladle bottom blowing flow, and performing alloy configuration to meet a target requirement on final components of a steel grade; and 6) after finishing adjusting components, performing soft stirring operation, measuring the temperature, sampling, and turning off the ladle argon blowing device to finish treating. The method realizes rapid desulfurization of the LF, and can shorten an overall melting cycle and improve the number of continuous casting furnaces and production efficiency.