Method for refining water extract of traditional Chinese medicine (TCM) composition

A refining method and composition technology, which can be used in pharmaceutical combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of long production cycle, reduced drug efficacy, and thermal damage, and achieve the effect of satisfying industrial rapid production.

Active Publication Date: 2012-09-05
BEIJING YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The refining of traditional Chinese medicine is mostly based on the polarity difference between components (solvent precipitation or extraction, adsorption separation, etc.) Component loss or heat damage, resulting in reduced efficacy, etc.

Method used

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  • Method for refining water extract of traditional Chinese medicine (TCM) composition
  • Method for refining water extract of traditional Chinese medicine (TCM) composition
  • Method for refining water extract of traditional Chinese medicine (TCM) composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The raw material formula is :

[0069] Ginseng 89g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 224g

[0070] Fried Suanzaoren 186g, Sangjisheng 186g, Radix Paeoniae Rubra 89g, Ground Beetle 75g

[0071] Gansong 89g Coptidis 45g Southern Schisandra 67g Keel 149g

[0072] The refining method is :

[0073] (a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0074] (b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong were reflux extracted three times with 70% ethanol, the extracts were combined, filtered, ethanol was recovered, concentrated to obtain an extract, and set aside;

[0075] (c) In the above prescription, the ground beetle is crus...

Embodiment 2

[0082] The raw material drug formula is:

[0083] Ginseng 45g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 225g Fried jujube kernel 186g Sangji 186g Radix paeoniae Rubra 89g Gansong 45g Ground beetle 35g Coptidis 45g Southern Schisandra 67g Keel 149g.

[0084] The refining method is :

[0085] (a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0086] (b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong were reflux extracted three times with 70% ethanol, the extracts were combined, filtered, ethanol was recovered, concentrated to obtain an extract, and set aside;

[0087] (c) In the above prescription, the ground beetle is crushed into fine powder...

Embodiment 3

[0094] The raw material drug formula is:

[0095] Ginseng 175g, Ophiopogon japonicus 192g, Cornus officinalis 421g, Salvia miltiorrhiza 440g, fried jujube kernel 395g, mulberry root 396g, red peony root 188g, ground beetle 98g, Gansong 188g, Coptidis 85g, Southern Schisandra 147g, keel 278g.

[0096] The refining method is :

[0097] (a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0098] (b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong were reflux extracted three times with 70% ethanol, the extracts were combined, filtered, ethanol was recovered, concentrated to obtain an extract, and set aside;

[0099] (c) In the above prescription, the ground beetle is crushed ...

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Abstract

The invention discloses a method for refining water extract of a traditional Chinese medicine (TCM) composition. The TCM composition is composed of TCMs such as ginseng, radix ophiopogonis, fructus corni, salvia miltiorrhiza, fried spina date seeds, parasitic loranthus, red paeony root, ground beetle and rhizoma nardostachyos and can effectively treat premature ventricular contraction of coronary heart diseases. The method has the following beneficial effects: an inorganic ceramic membrane is adopted for filtration to refine the extract of the TCM composition; the active ingredients have high transfer rate; the extract can be industrially produced; the material liquid is simple to process; and the inorganic ceramic membrane is convenient to wash and can be regenerated.

Description

technical field [0001] The invention relates to a method for refining the water extract of a Chinese medicine composition, in particular to a method for refining the water extract of a Chinese medicine composition through inorganic ceramic membrane filtration. Background technique [0002] The main purpose of the production process of traditional Chinese medicine preparations is to enrich the active ingredients and remove invalid impurities. The refining of traditional Chinese medicine is mostly based on the polarity difference between components (solvent precipitation or extraction, adsorption separation, etc.) Component loss or heat damage, resulting in reduced efficacy, etc. Inorganic ceramic membrane separation technology is based on the principle of sieving, which can separate suspended particles of 0.05-10 μm and some macromolecular impurities in the solution. Inorganic ceramic membranes for traditional Chinese medicine separation are mostly Al 2 o 3 The ceramic me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P9/06A61K35/02A61K35/64
Inventor 王曙宾郭珊珊周东明黄开毅
Owner BEIJING YILING PHARMA
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