Process for purifying L-phenylalanine

A technology of phenylalanine and process, which is applied in the process field of purifying L-phenylalanine by membrane method, can solve problems such as clean production analysis, and achieve the effects of low processing cost, convenient operation and low labor intensity

Inactive Publication Date: 2012-09-12
HANGZHOU BLUETEC ENVIRONMENTAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most domestic phenylalanine purification systems do not systematically analyze the process characteristics in

Method used

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  • Process for purifying L-phenylalanine

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Experimental program
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Effect test

Embodiment 1

[0055] 100 tons of fermented liquid with a phenylalanine content of 4.8% is pumped into the ceramic membrane system and filtered through the ceramic membrane. The produced water enters the next step, and the concentrated water is returned to the raw material tank. When the remaining raw material liquid in the raw material tank is about 6.7 Add pure water to the raw material tank for diafiltration. The flow rate of pure water is the same as that of the product water. When the residual phenylalanine in the raw material tank is <0.5%, the diafiltration is completed, and a total of 120 tons of ceramic membrane filtrate and 5 tons of ceramic membrane filtrate are obtained. tons of concentrated liquid containing bacteria and suspended matter; the concentrated liquid obtained in this process can be used as feed and other by-products. The permeate with a content of 4% enters the ion exchange system, phenylalanine is adsorbed to the separation column, and then eluted with ammonia water ...

Embodiment 2

[0058] 100T fermented liquid with a phenylalanine content of 6% is sent to the ceramic membrane system through a water pump, and after being filtered by the ceramic membrane, the produced water enters the next step, and the concentrated water is returned to the raw material tank. When the remaining material liquid in the raw material tank is 7T, Add pure water to the raw material tank for diafiltration. The flow rate of pure water is the same as that of the product water. When the residual phenylalanine in the raw material tank is <0.5%, the diafiltration is completed, and a total of 120T ceramic membrane filtrate and 5T concentrated solution are obtained. The concentrate can be used as feed and other by-products. The phenylalanine content in the product water was 5%. The phenylalanine permeate enters the ion exchange system, adsorbs phenylalanine to the separation column, and then uses ammonia water with a concentration of 1N to elute. After completion, 240T phenylalanine fee...

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Abstract

The invention relates to a process for purifying L-phenylalanine. The process comprises the following steps of performing membrane separation treatment on the fermentation liquor of L-phenylalanine in a ceramic membrane system, performing ion exchange treatment in an ion exchange system, performing ultra-filtration treatment, performing nanofiltration treatment and performing circulation filtration respectively; and when the content of phenylalanine in a residual solution reaches 0.1 percent, removing the residual solution to obtain a solution of phenylalanine. The process has the advantages of reasonable process combination and low investment and operational cost; and by the method, bacteria in the concentrated solution of the ceramic membrane can be appropriately treated, and an aim of changing wastes into valuables is fulfilled.

Description

technical field [0001] The invention relates to a preparation process for purifying L-phenylalanine, in particular to a process for purifying L-phenylalanine by membrane method. Background technique [0002] L-phenylalanine is an important amino acid with biological activity. Humans and animals cannot synthesize it by themselves and must ingest it from the outside. It is one of the eight essential amino acids. It is not only an important biochemical nutrient substance, but also can be safely added to any food and beverage as the main raw material of aspartame, and it is also a synthetic raw material of various drugs. L-phenylalanine has stable quality and can be stored for a long time under heat, air and light. The main uses of L-phenylalanine are: the main raw material for the synthesis of Aspartame, amino acid raw materials, pharmaceutical intermediates, feed and food additives, synthetic vitamins and nutritional fortifiers, etc. Synthesize anticancer drugs, antiviral dr...

Claims

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Application Information

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IPC IPC(8): C07C229/36C07C227/40B01D61/58
Inventor 楼永通李嘉
Owner HANGZHOU BLUETEC ENVIRONMENTAL TECH
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