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Cimetidine injection and preparation process

A technology of cimetidine and injection, which is applied in the field of preparation of cimetidine medicaments, can solve the problems of animal body stress response, unfavorable disease treatment, poor palatability, etc., and achieve reduced injection times, high active ingredient content, The effect of avoiding harm

Inactive Publication Date: 2012-09-19
DINGZHENG ANIMAL PHARMA TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Cimetidine is easily soluble in methanol, dissolved in ethanol, slightly soluble in isopropanol, slightly soluble in water, easily soluble in dilute hydrochloric acid, and cimetidine has the disadvantages of bitter taste and poor palatability. , invented cimetidine injection, but its active ingredient content is only 0.4%. In clinical use, a large number of injections are needed to meet the needs of animals. irritative reaction, which is not conducive to the treatment of diseases

Method used

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  • Cimetidine injection and preparation process
  • Cimetidine injection and preparation process
  • Cimetidine injection and preparation process

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preparation example Construction

[0022] The preparation method of above-mentioned cimetidine injection comprises the following steps:

[0023] (1) Mix cimetidine with water for injection to form a suspension;

[0024] ⑵ After adding co-solvent to the suspension, continue to add water for injection to make the suspension into a colorless and transparent solution;

[0025] ⑶ adding antioxidants;

[0026] (4) adding chelating agent;

[0027] (5) Dilute the volume to 100 ml with water for injection, filter and sterilize to obtain the finished product. Advantage and positive effect of the present invention are:

Embodiment 1

[0029] (1) Mix 10 grams of cimetidine with 50 ml of water for injection to form a suspension;

[0030] ⑵ Add 20 grams of tartaric acid to the suspension, and then continue to add water for injection to make the suspension into a colorless and transparent solution;

[0031] (3) Add 0.2 gram of sodium metabisulfite;

[0032] (4) Add 0.2 grams of EDTA;

[0033] (5) Dilute the volume of water for injection to 100ml, filter and sterilize with a 0.22-micron filter membrane, and make a finished product after inspection and filling.

[0034] The active ingredient content of the prepared cimetidine injection is: 10%.

Embodiment 2

[0036] (1) Mix 15 grams of cimetidine with 50 ml of water for injection to form a suspension;

[0037] ⑵ Add 10 grams of lactic acid and 15 grams of butyrosine to the suspension, and then continue to add water for injection, so that the suspension forms a colorless and transparent solution;

[0038] (3) Add 0.4 gram of sodium thiosulfate;

[0039] (4) Add 1.0 g of EDTA;

[0040] (5) Dilute the volume of water for injection to 100ml, filter and sterilize with a 0.22 micron filter membrane, and make the finished product after inspection and filling.

[0041] The active ingredient content of the prepared cimetidine injection is: 15%.

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Abstract

The invention relates to cimetidine injection. Each 100 milliliter of cimetidine injection comprises components of 10-20g of cimetidine, 20-40g of cosolvent, 0.2-04g of antioxidant and 0.2-1.0 g of chelating agent. The cosolvent, the antioxidant and the chelating agent are added into the cimetidine serving as the essential component so that homogeneous and stable colorless transparent injection solution is formed. The injection is stable in characters after long-term preservation, has high content of active ingredients and is convenient and safe to use. The single injection quantity is increased greatly, injection frequency is lowered, and injury to animal bodies due to frequent injection is avoided.

Description

technical field [0001] The invention relates to the technical field of preparation of cimetidine medicaments, in particular to a cimetidine injection and a preparation method thereof. Background technique [0002] Cimetidine (N'-methyl-N"-[2[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-N-cyanoguanidine), White or off-white crystalline powder, almost odorless, bitter in taste, it has the effect of inhibiting gastric acid secretion, prevents and protects corrosive gastritis caused by chemical stimulation, and also has effect on stress gastritis and upper gastrointestinal bleeding Obvious curative effect. [0003] Cimetidine is easily soluble in methanol, dissolved in ethanol, slightly soluble in isopropanol, slightly soluble in water, easily soluble in dilute hydrochloric acid, cimetidine has the disadvantages of bitter taste and poor palatability, people have studied , invented cimetidine injection, but its active ingredient content is only 0.4%. In clinical use, a large...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4164A61K47/34A61K47/32A61K47/18A61K47/12A61P1/04
Inventor 刘鼎阔董惠峰王立红张勇张俊霞张凤洪
Owner DINGZHENG ANIMAL PHARMA TIANJIN
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