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Cefalexin-borneol composition

A technology for cephalexin and cephalexin, which is applied to the active ingredients of hydroxyl compounds, antibacterial drugs, organic active ingredients, etc., can solve the problems such as the increase of drug-resistant bacteria and the ineffective treatment effect of cephalexin, and achieve the improvement of drug resistance. Phenomenon, effect with broad application prospects

Inactive Publication Date: 2012-09-19
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to address the deficiencies in the prior art, such as the increase of drug-resistant bacteria and the inconspicuous therapeutic effect of cephalexin, to provide a cephalexin borneol composition, so as to improve the sensitivity of these drug-resistant strains to drugs

Method used

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  • Cefalexin-borneol composition
  • Cefalexin-borneol composition
  • Cefalexin-borneol composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 antibacterial experiment

[0020] The cephalexin borneol composition was taken for antibacterial experiment.

[0021] Simple borneol group:

[0022] Take a sterilized test tube, add 7.2mL of LB medium to tube 1, then add 0.8mL of borneol liquid, take out 4mL of the mixed solution from tube 1 by the 2-fold dilution method, place it in test tube 2 containing 4mL of LB medium, and mix Mix well, dilute to the 8th tube according to law, take out 4mL, and discard. Add 0.1 mL of bacterial suspension with a turbidity of 1 McFarland unit to each tube, and shake well.

[0023] Simple cephalexin group:

[0024] Take a sterilized test tube, add 7.2mL of LB medium to tube 1, then add 0.8m cephalexin liquid, take out 4mL of the mixed solution from tube 1 by 2-fold dilution, and place it in test tube 2 containing 4mL of LB medium. Mix well, dilute to the 8th tube according to law, take out 4mL, and discard. Add 0.1 mL of bacterial suspension with a turbidity of 1 McF...

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Abstract

The invention discloses a cefalexin-borneol composition belonging to the technical field of the preparation of medicines. The cefalexin-borneol composition comprises cefalexin and borneol according to the mass ratio of 1:0.1 to 1:10, wherein the optimal mass proportion is 1:1. The composition can be prepared into various medicament forms, such as tablets, capsules, granules, slow release preparations and injections, by using a conventional medicine preparation method and auxiliary materials which are universal pharmaceutically. The composition has a very good inhibiting action to various medicine-resistant bacteria, and the minimal inhibitory concentration (MIC) value is lowered at an order of magnitude. Therefore, the phenomenon of medicine resistance of common antibiotics is greatly improved, and the application prospect is extensive.

Description

technical field [0001] The invention relates to the field of antibacterial drugs, in particular to a cephalexin borneol composition. Background technique [0002] Cefalexin, chemical name: (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-aza Bicyclo[4.2.0]oct-2-ene-2-carboxylic acid-hydrate, formula C 16 h 17 N 3 o 4 S. h 2 O, the structural formula is as formula (Ⅰ): [0003] [0004] ( ) [0005] This product is a β-lactam antibacterial drug, the first generation of broad-spectrum enzyme-resistant cephalosporins, and its antibacterial spectrum is similar to that of cephalothin but its effect is weaker. Strong antibacterial activity against Gram-positive bacteria, Staphylococcus aureus, Penicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus viridans, Hemolytic streptococcus, Pneumococcus, Neisseria gonorrhoeae, Bacillus anthracis, Bacillus tetani , diphtheria, Clostridium, and Wei Rong bacteria have strong activi...

Claims

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Application Information

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IPC IPC(8): A61K31/545A61P31/04A61K31/045
CPCY02A50/30
Inventor 李明亚陈燕忠冼嘉雯
Owner GUANGDONG PHARMA UNIV