Rhizoma imperatae water-stage extract and application thereof

An extract of Imperata imperinae and the technology of Imperatae imperatae, applied in the field of Imperatae imperatae extract, can solve the problem of not finding effective anti-inflammatory parts of Imperatae imperatae

Active Publication Date: 2014-03-26
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above studies did not find the anti-inflammatory effective parts of Imperatae imperinae, and no relevant reports have been found in other literatures.

Method used

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  • Rhizoma imperatae water-stage extract and application thereof
  • Rhizoma imperatae water-stage extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 13.5Kg of imperina root coarse powder, reflux extraction with 70wt% ethanol aqueous solution twice (the first solvent consumption is 81Kg, the second solvent consumption is 54Kg), each time for one hour, the steam pressure is controlled at 0.05~0.1MPa, the extract After concentrating under reduced pressure, 760 g of extract was obtained. Take 580g of the extract, suspend it with 2Kg of hot water (50-60°C), then extract it with petroleum ether, extract the obtained aqueous phase (raffinate) and then extract it with ethyl acetate, and then extract it with ethyl acetate. The aqueous phase (raffinate) was extracted with n-butanol. When using petroleum ether, ethyl acetate and n-butanol to extract separately, the number of extractions of each extractant is generally based on the fact that the color of the extract does not change. In this example, 4 extractions were performed with petroleum ether, 10 extractions with ethyl acetate, and 14 extractions with n-butanol; 1 L...

Embodiment 2

[0033] Take 13.5Kg of imperina root coarse powder, reflux extraction with 50wt% ethanol aqueous solution twice (the first solvent consumption is 65Kg, the second solvent consumption is 43Kg), each time for one hour, the steam pressure is controlled at 0.05~0.1MPa, the extract After concentrating under reduced pressure, 760 g of extract was obtained. Take 580g of the extract, suspend it with 1.74Kg of hot water (50-60°C), and then extract it with petroleum ether first, then extract the obtained aqueous phase (raffinate) with ethyl acetate, after ethyl acetate extraction The resulting aqueous phase (raffinate) is further extracted with n-butanol. When using petroleum ether, ethyl acetate and n-butanol to extract separately, the number of extractions of each extractant is generally based on the fact that the color of the extract does not change. In this example, 5 extractions were performed with petroleum ether, 8 extractions with ethyl acetate, and 13 extractions with n-butanol...

Embodiment 3

[0035] Take 13.5Kg of imperina root coarse powder, reflux extraction with 90wt% ethanol aqueous solution twice (the first solvent consumption is 97Kg, the second solvent consumption is 65Kg), each time for one hour, the steam pressure is controlled at 0.05~0.1MPa, the extract After concentrating under reduced pressure, 760 g of extract was obtained. Take 580g of extract, suspend it with 2.9Kg of hot water (50-60°C), then extract it with petroleum ether first, then extract the obtained aqueous phase (raffinate) with ethyl acetate, after ethyl acetate extraction The resulting aqueous phase (raffinate) is further extracted with n-butanol. When using petroleum ether, ethyl acetate and n-butanol to extract separately, the number of extractions of each extractant is generally based on the fact that the color of the extract does not change. In this example, petroleum ether was used for 4 extractions, ethyl acetate was used for 10 extractions, and n-butanol was used for 15 extraction...

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Abstract

The invention provides a rhizoma imperatae water-stage extract which is prepared by the following steps of: 1) performing backflow extraction of the coarse powder of rhizoma imperatae by use of 50-90% ethanol water by weight, and concentrating the extracting solution to obtain extract; and 2) adding water into the extract obtained in the step 1) and mixing to obtain suspension, extracting with petroleum ether, ethyl acetate and n-butyl alcohol sequentially, evaporating the obtained raffinate, and drying to obtain the rhizoma imperatae water-stage extract. In the invention, the effective anti-inflammation part in the rhizoma imperatae is screened through stage extraction to obtain the rhizoma imperatae water-stage extract. Among all stage extracts of rhizoma imperatae, the extract has the most obvious effect on inhibiting the mouse auricle swelling inflammation caused by paraxylene, and is expected to be used as an anti-inflammation medicine for preventing inflammation.

Description

technical field [0001] The present invention relates to an extract of Imperata rhizome, in particular to an extract of Imperata rhizome water section with anti-inflammatory effect and its application in anti-inflammation. Background technique [0002] The rhizome of Imperata cylindrica Beauv.var.major (Nees) C.E.Hubb. Its English name is rhizome of Lalang Grass, and its Latin name is Rhizoma Imperatae cylindricae. , white flower root ("Rihuazi Materia Medica"), Dijiegen ("Qinghai Medicinal Materials"), thatch root ("Jiangsu Zhiyao Zhi"), sweet grass root ("Hebei Medicinal Materials"), silky grass root ("Chinese Medicine" ). [0003] Imperata coronata is produced in most parts of the country, especially in North China. It is sweet in taste and cold in nature. Indications for jaundice, edema, thirst, bleeding, lung heat cough, stomach heat vomiting, fever, primary glomerulonephritis, stranguria syndrome, panting syndrome and other diseases. It has the functions of hemosta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P29/00A61K125/00
Inventor 丁丽丽刘轩杨莉王峥涛詹常森沈丹萍黄昕明张正光
Owner HEHUANG PHARMA SHANGHAI
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