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Tanshinone microemulsion and preparation method thereof

A technology of tanshinone and microemulsion, which is applied in the field of carrier systems in cosmetics technology, can solve the problems of poor water solubility, inability to directly apply cosmetics, and low tanshinone content, and achieve the effects of good stability, convenient preparation, and high content of active substances

Inactive Publication Date: 2012-09-26
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a mild microemulsion preparation with high stability and high tanshinone loading content, which solves the problems of poor water solubility, low tanshinone content, and inability to be directly applied to cosmetics in the prior art.

Method used

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  • Tanshinone microemulsion and preparation method thereof
  • Tanshinone microemulsion and preparation method thereof
  • Tanshinone microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 tanshinone microemulsion

[0048] Composition formula

[0049]

[0050] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0051] 1. Weigh 2.5 grams of triacetin, 3.6 grams of Tween 20, 4.4 grams of PEG-40 hydrogenated castor oil, 3.0 grams of ethoxydiethylene glycol, and 7.4 grams of ethanol into a beaker, and heat in a water bath at 40°C .

[0052] 2. Weigh 0.1 g of tanshinone and add it into the molten oil phase.

[0053] 3. Weigh 79.0 g of deionized water into a beaker, and heat it in a water bath at 40°C.

[0054] 5. Add the water phase to the above system and stir evenly;

[0055] 6. The uniformly stirred high-temperature microemulsion system was cooled and filtered to obtain the microemulsion. The particle size of the microemulsion was measured by photon correlation spectroscopy (PCS) to be 23nm.

Embodiment 2

[0056] The preparation of embodiment 2 tanshinone microemulsions

[0057] Composition formula

[0058]

[0059]

[0060] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0061] 1. Weigh 10.0 grams of triacetin, 4.2 grams of Tween 20, 4.0 grams of PEG-40 hydrogenated castor oil, 2.8 grams of ethoxydiethylene glycol, and 8.0 grams of ethanol in a beaker, and heat in a water bath at 40°C .

[0062] 2. Weigh 1.0 g of tanshinone and add it to the molten oil phase.

[0063] 3. Weigh 70.0 g of deionized water into a beaker, and heat it in a water bath at 40°C.

[0064] 5. Add the water phase to the above system and stir evenly;

[0065] 6. The uniformly stirred high-temperature microemulsion system is cooled and filtered to obtain the microemulsion. The particle size of the microemulsion measured by photon correlation spectroscopy (PCS) is 28nm.

Embodiment 3

[0066] The preparation of embodiment 3 tanshinone microemulsions

[0067] Composition formula

[0068]

[0069] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0070] 1. Weigh 12.0 grams of triacetin, 4.5 grams of Tween 20, 5.0 grams of PEG-40 hydrogenated castor oil, 3.2 grams of ethoxydiethylene glycol, and 10.0 grams of ethanol in a beaker, and heat in a water bath at 40°C .

[0071] 2. Weigh 1.8 grams of tanshinone and add it to the molten oil phase.

[0072] 3. Weigh 63.5 grams of deionized water into a beaker, and heat it in a water bath at 40°C.

[0073] 5. Add the water phase to the above system and stir evenly;

[0074] 6. The uniformly stirred high-temperature microemulsion system was cooled and filtered to obtain the microemulsion. The particle size of the microemulsion was measured by photon correlation spectroscopy (PCS) to be 34nm.

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Abstract

The invention discloses a tanshinone microemulsion. A carrier is loaded with tanshinone. The microemulsion has antibacterial, antioxidant, acne treatment and pockmark treatment effects. The invention is characterized in that the method for preparing the microemulsion is a constant-temperature stirring method. The carrier comprises the following components in percentage by weight: 0.01 to 5 percent of tanshinone, 8 to 25 percent of emulsifier, 2 to 18 percent of lipid material and the balance of deionized water, wherein the emulsifier is made of PEG-40, hydrogenated castor oil, PEG-8 caprylin / caprin, polyoxyethylene (21) stearate, Tween-20, Tween-60, Tween-80, ethyoxyl diethylene glycol, lecithin, polyethyleneglycol (PEG) (30) dipolyhydroxy stea, Polyethyleneglycol (PEG)-200, ethanol, propylene glycol, or 1,3-butylene glycol. The lipid material may be glyceryl triacetate, octyl and decyl glycerate, glyceride (L), isopropyl myristate, glyceryl monostearate or the ACETEM. The microemulsion has high stability and can be loaded with high-content tanshinone; the preparation method is simple and controllable with good repeating capacity; and the microemulsion can be used in cosmetics for treating acne and pockmark.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetic technology, and relates to a nanoscale carrier and a preparation method thereof, in particular to a preparation method of a microemulsion with tanshinone as an active ingredient. Background technique [0002] Salvia miltiorrhiza is slightly cold in nature and bitter in taste. It has the effects of promoting blood circulation and removing blood stasis, nourishing blood to calm the nerves, regulating menstruation and relieving pain, cooling blood and eliminating carbuncle. It is a commonly used traditional Chinese medicine for promoting blood circulation and removing blood stasis. Tanshinone (tanshinone) in the traditional Chinese medicine Salvia (Salvia miltiorrhizaBge) content is relatively high, has strong physiological activity, is one of the main active ingredients of Danshen. Studies have shown that tanshinones all contain o-quinone or p-quinone structure, which have natura...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/63A61K8/86A61K8/92A61Q19/00
Inventor 夏强郭星木
Owner SOUTHEAST UNIV
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