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Cerium-loaded functional absorbable orthopedic instrument material and preparation method thereof

A technology of functionalization and carrier materials, applied in the field of absorbable orthopedic internal fixation devices and its preparation, cerium-loaded functionalized absorbable orthopedic devices and its preparation, can solve poor infiltration, unsatisfactory interface bonding, and deterioration of mechanical properties of orthopedic devices To achieve the effect of promoting fracture healing, improving long-acting antibacterial and anti-inflammatory effects, and improving antibacterial and anti-inflammatory properties

Inactive Publication Date: 2015-04-01
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor wettability between cerium-containing salts or ceramic particles and the polymer, the interface bonding is not ideal, and its addition will deteriorate the unsatisfactory mechanical properties of this type of orthopedic device itself.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] The invention relates to a cerium-carrying functionalized absorbable orthopedic device and a preparation method thereof. The material of the orthopedic device is composed of an absorbable polymer, graphene dispersed in the polymer for reinforcement and toughening, loaded with Composed of degradable carrier materials of rare earth element cerium, it can slowly release rare earth element cerium with antibacterial and anti-inflammatory effects during use. The composite loading technology is effectively loaded on the degradable carrier material of pure magnesium or magnesium alloy wire or plate containing a porous ceramic layer of hydroxyapatite on the surface, and the volume fraction of the pure magnesium or magnesium alloy wire or plate carrier material is The pore size of the surface porous ceramic layer is 1-50 μm, the layer thickness is 1-100 μm, and the volume percentage of graphene is 0.01%-5%. The specific preparation steps of the orthopedic device are as follows:

...

Embodiment 1

[0028] The selected biodegradable absorbent polymer is polylactic acid. The load carrier is pure magnesium, and the volume fraction of pure magnesium is 20%. The preparation process is as follows:

[0029] 1) Drawing pure magnesium into a wire with a diameter of 0.3mm;

[0030] 2) Preparation of Ce(OH) 4 Colloidal solution, electrophoresis-micro-arc oxidation treatment: 1L0.1mol / L cerium nitrate solution and excess 30%H 2 o 2 Mixing under slow stirring, the solution starts to turn yellow and then becomes orange red, and after 30 minutes, dilute ammonia water is added dropwise to obtain a colloidal solution. Add the colloidal solution to the micro-arc oxidation electrolyte. The main components of the electrolyte are 10g / L sodium silicate, 2g / L NaOH and 8g / L hydroxyapatite nanoparticles, immerse the magnesium wire in it, and apply a voltage of 400V 15 minutes of electrophoresis-micro-arc oxidation treatment to form a layer of cerium-containing porous ceramic protective layer...

Embodiment 2

[0034] The selected degradable absorbent polymer is PGLA, a copolymer of polylactic acid and polyglycolic acid. The load carrier is AZ31B magnesium alloy with a volume fraction of 40%. The preparation process is as follows:

[0035] 1) Hot rolling the magnesium alloy into a plate with a thickness of 0.4mm;

[0036] 2) Preparation of Ce(OH) 4 Colloidal solution, electrophoresis-micro-arc oxidation treatment: 1L0.15mol / L cerium nitrate solution and excess 30%H 2 o 2 Mix under slow stirring, the solution starts to turn yellow and then orange, and after 25 minutes, dilute ammonia water is added dropwise to obtain a colloidal solution. Add the solution to the micro-arc oxidation electrolyte, the main components of which are 8g / L sodium silicate, 3g / L NaOH, and 10g / L hydroxyapatite nanoparticles, immerse the magnesium alloy plate in it, and apply a voltage of 380V. Perform electrophoresis-micro-arc oxidation treatment for 25 minutes to form a porous ceramic protective layer cont...

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PUM

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Abstract

The invention discloses a cerium-loaded functional absorbable orthopedic instrument material and a preparation method thereof. The orthopedic instrument material consists of an absorbable high-molecular polymer, graphene dispersed and distributed in the polymer and used for strengthening and toughening, and a degradable carrier material loaded with rare earth element cerium, wherein the rare earth element cerium having antisepsis and anti-inflammation functions is slowly released in a use process; the rare earth element cerium is effectively loaded on the degradable carrier material, namely a pure magnesium or magnesium alloy wire or sheet which contains a hydroxyapatite porous ceramic layer on surface through a special dual-composite loading technology formed from electrophoresis-micro arc oxidation and chemical impregnation ion exchange reaction. A bar or sheet is firstly prepared through thermal mould pressing, extrusion, injection molding, drawing or other methods, and the bar or sheet is mechanically processed into such bone repair and fixation instruments as absorbable functional bone nail and bone board; the material disclosed by the invention is wide in application prospect.

Description

technical field [0001] The invention relates to an absorbable orthopedic internal fixation device with special functions and a preparation method thereof, which can slowly release rare earth element cerium with antibacterial and anti-inflammatory effects during the degradation process, has antibacterial and anti-inflammatory functions, and belongs to the technical field of orthopedic devices. Specifically, it is a cerium-carrying functionalized absorbable orthopedic device and a preparation method thereof. Background technique [0002] Bioabsorbable polymers have excellent biocompatibility and degradability without the need for secondary surgical removal, and the strength can be controlled to be close to normal bone. It gradually replaces traditional orthopedic fixation materials such as stainless steel and titanium alloys in clinical practice. Become the material of choice for orthopedic fixation devices. Absorbable polymer orthopedic devices also have problems such as wea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61L31/16A61L31/18C25D13/02C25D15/00C25D11/30
Inventor 储成林李旋白晶郭超薛烽林萍华
Owner SOUTHEAST UNIV
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