Clopidogrel and salt submicron emulsion injection thereof as well as preparation method of same

A technology of clopidogrel and injection, which is applied in the field of medicine, can solve the problems such as the preparation method of clopidogrel and its salt submicroemulsion injection, and achieve the effects of avoiding and covering up bad smell, low solubility and convenient medication
CN102697724AInactive Publication Date: 2012-10-03SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2012-10-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicine and relates to clopidogrel and salt submicron emulsion injection thereof as well as a preparation method of the clopidogrel and the salt submicron emulsion injection thereof. Particularly, the invention provides clopidogrel, salt submicron emulsion injection including clopidogrel, salt, oil for injection, assistant emulsifier, isoosmotic adjusting agents, pH adjusting agents and water for injection, and a preparation method of the clopidogrel and the salt submicron emulsion injection. 100 mL of the injection comprises clopidogrel, 0.05 g to 0.15 g salt (measured according to clopidogrel), 5 g to 30 g of oil for injection, 0.5 g to 3.4 g of emulsifier, 0 g to 1 g of assistant emulsifier, 2.0 g to 4.0 g of isoosmotic adjusting agents, and 7.0 g to 9.0 g of pH adjusting agents, and 100 mL of water for injection is added. The clopidogrel and the salt submicron emulsion injection thereof, provided by the invention, have the physical chemical property conforming to the requirement of drug for intravenous use and are suitable for clinical application.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a submicroemulsion injection of clopidogrel and its salt and a preparation method thereof. Background technique

[0002] Clopidogrel, the second thienopyridine drug, is an adenosine diphosphate (ADP) receptor inhibitor. Its chemical name is (S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)acetic acid methyl ester. The chemical structural formula is as follows:

[0003]

[0004] Clopidogrel is a platelet aggregation inhibitor, which can selectively and irreversibly inhibit the binding of adenosine diphosphate (ADP) to its platelet receptor and the secondary ADP-mediated activation of the glycoprotein GPⅡb / Ⅲa complex, thereby inhibiting Mutual aggregation of platelets. In addition, clopidogrel can also block the platelet activation expansion caused by ADP release, thereby inhibiting platelet aggregation induced by other agonists.

[0005] Clopidogrel can be used t...

Claims

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