Composition containing litchi seed extract for preventing or treating fatty liver or obesity

A composition and fatty liver technology, applied in the direction of food ingredients containing natural extracts, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of non-alcoholic fatty liver patients and achieve excellent active effects

Inactive Publication Date: 2012-10-17
YONSEI UNIV TECH HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, an ideal drug that has no side effects and is effective in the trea...

Method used

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  • Composition containing litchi seed extract for preventing or treating fatty liver or obesity
  • Composition containing litchi seed extract for preventing or treating fatty liver or obesity
  • Composition containing litchi seed extract for preventing or treating fatty liver or obesity

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Embodiment approach

[0066] Hereinafter, the present invention will be described in more detail through examples. These embodiments are only used to illustrate the present invention more specifically. According to the gist of the present invention, the scope of the present invention is not limited to these embodiments, which is obvious to those skilled in the art to which the present invention belongs.

[0067] 【Example】

[0068] Unless otherwise stated, solids / solids are (weight / weight) parts or percentages (%), solids / liquids are (weight / volume) parts or percentages, and liquids / liquids are (volume / volume) parts or percentage.

Embodiment 1

[0069] [Example 1: Preparation of Litchi Kernel Extract]

[0070] After 1.2 kg of litchi (Litchi chinensis Sonn.) seeds were made into coarse powder in a pulverizer, 6 l of alcohol (ethanol) was added, and hot water extraction was performed 3 times in a reflux extractor. After filtering the extract with filter paper, it was concentrated in a vacuum concentrator and then dried using a freeze dryer to obtain 25.5 g of the extract (yield 2.1%) for the experiment.

Embodiment 2

[0071] [Example 2: Body weight and visceral fat reduction effect using litchi seed extract in mice]

[0072] 【Experimental feed preparation and feeding of experimental animals】

[0073] The obesity-inducing diet used in this experiment was a high-fat control diet (high fat diet, HFD: 40% fat calories (fat calories), 17g lard + 3% corn oil (corn oil) / 100g food (diet )), the feed supplemented with litchi seed extract (Litch semen-supplemented high fat diet, LSD) has the same composition as HFD, and contains litchi seed extract at a level of 0.5%. Normal diet (ND) was based on AIN-76 rodent diet composition (American Institute of Nutrition, Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J. Nutr., 107:1340-1348, (1977)) deployment (Table 1).

[0074] 【Table 1】

[0075]

[0076] 1) Mineral mixture (g / kg of mix): CaHPO 4 500; NaCl 74; K 2 h 6 o 7 h 2 O220; K 2 SO 4 52; MgO 24; MnCO 3 3.5; Fe (C 6 h 5 o 7 )·6H ...

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Abstract

The present invention relates to a composition containing extracts of Litchi seed for preventing or treating fatty liver or obesity. The composition of the present invention may induce the reduction of body fat mass, intestinal fat mass, total cholesterol concentration, levels of C/EBPa and PPAR?2 which are important factors of nuclear transcription in generating fat tissue, and the expression amounts of the aP2 gene which is the target gene of C/EBPa and PPAR?2, and eventually activate the prevention or treatment of obesity. The composition of the present invention may inhibit the progression of fatty liver diseases and treat same by maintaining the morphological, structural, and physiological functions of the liver, in addition to having the effect of preventing the development said fatty liver diseases.; Moreover, the composition of the present invention may improve fat accumulation in liver tissue by reducing the lipid content level in the liver tissue, and may have the effects of preventing the development of fatty liver, inhibiting the progression or improving the condition of patients by normalizing liver function marker enzyme expression. In addition, the present invention provides preliminary data showing that Litchi seed extracts, as a medicinal material and food, are efficacious in preventing and treating fatty liver diseases.

Description

【Technical field】 [0001] The present invention relates to a composition for preventing or treating obesity or fatty liver comprising a litchi seed extract, and a method for preventing or treating obesity or fatty liver comprising a step of administering the composition to a subject in need. 【Background technique】 [0002] According to the Korean Pharmacopoeia of Chinese Herbal Medicine (Crude Drugs) specification collection, litchi core (Litchi core) is the seed of Litchi (Litchi chinensis Sonnerat) belonging to Sapindaceae (Sapindaceae). The scientific name is Litchi semen, also known as Dan Li core, There are different names for Lihe, Lizhi, Lizhihe, Zhihe, Liren and Lihe. The litchi core is oval-oval, slightly flattened on one side, with a length of 12mm-22mm and a diameter of 6mm-16mm. The surface is brownish-red or purple-brown, smooth and shiny, with slightly longitudinally wrinkled fine ripples, one end is round, and the texture is relatively hard. Moreover, it is t...

Claims

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Application Information

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IPC IPC(8): A61K36/77A61P3/04A61P3/00
CPCA61K36/77A61P3/00A61P3/04A23L33/105A23V2200/332A23V2250/21
Inventor 朴太瑄黄完均
Owner YONSEI UNIV TECH HLDG
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