Application of hydroxytyrosol in medicine used for preventing and curing obesity

A hydroxytyrosol and obesity technology, applied in the fields of biology and medicine, can solve problems such as increasing fat burning and consumption, and achieve the effects of promoting bone growth and development, high curative effect, and good bone growth and development.

Inactive Publication Date: 2012-10-31
XI AN JIAOTONG UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0006] In order to overcome the deficiencies in the existing methods of treating obesity in the prior art, the object of the present invention is to provide the application of hydroxytyrosol in the medicine for preventing and treating obesity, by taking in effective natural nutrient-hydroxytyrosol under the situation of normal diet, promoting the function, increase fat burning and consumption, and achieve the goal of weight loss without affecting food intake

Method used

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  • Application of hydroxytyrosol in medicine used for preventing and curing obesity
  • Application of hydroxytyrosol in medicine used for preventing and curing obesity
  • Application of hydroxytyrosol in medicine used for preventing and curing obesity

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] 1. Animal feeding

[0025] C57 male mice were purchased from Shanghai Slack Animal Co., Ltd. Mice were kept in a room with controlled temperature (22 to 28 degrees) and humidity (60%). The lights in the room were maintained in a 12-hour day and 12-hour night cycle. During the experiment, the mice were free to eat and drink. water.

[0026] 2. Establishment of Obesity Model

[0027] The experimental mice were divided into four groups, 10 in each group. The four groups were: (1) normal diet group; (2) high-fat diet group; (3) high-fat diet group was fed with 10 mg / kg of hydroxytyrosol every day; (4) high-fat diet group was fed with daily 50 mg / kg of hydroxytyrosol. The experimental period is 4 months.

[0028] 3. Related results

[0029] (1) Inhibitory effect of hydroxytyrosol on obesity induced by high-fat diet

[0030] The weight of the mice was measured before and after the experiment, and the weight of the mice at the beginning of the experiment was subtracted ...

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Abstract

The invention relates to an application of hydroxytyrosol in a medicine used for preventing and curing obesity. The hydroxytyrosol is capable of effectively reducing the increment of weight, as well as accumulation of epididymis fat and perirenal fat during the generating process of obesity. Moreover, the hydroxy tyrosol can reduce the contents of triglyceride, free fatty acid and hunger insulinum in blood; and in addition, the hydroxy tyrosol is capable of obviously restraining the generation of fatty liver, reducing the weight of the liver, and restraining the accumulation of the triglyceride and cholesterol in the liver. Therefore, the hydroxy tyrosol has the function of promoting fat metabolism and cholesterol metabolism, can effectively protect the liver function, and cure and prevent the occurrence of obesity, and belongs to a drug with high curative effect, safety and simplicity.

Description

technical field [0001] The invention relates to the fields of biology and medicine, in particular to the application of hydroxytyrosol in medicines for preventing and treating obesity. Background technique [0002] Obesity is a chronic disease. According to the estimation of the World Health Organization, it is the most easily overlooked disease facing human beings, but the incidence rate is rising rapidly. It is mainly manifested in a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. [0003] The occurrence of obesity can lead to the occurrence of various physical and psychological diseases such as diabetes, cancer, cardiovascular disease, non-alcoholic fatty liver, osteoarthritis, obstructive sleep apnea syndrome, social impairment, etc. Obesity is also one of the leading preventable causes of death. A large number of studies in the United States and Europe have shown that th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P3/04A61P1/16A61P3/06
Inventor 刘健康冯智辉龙建纲邹璇
Owner XI AN JIAOTONG UNIV
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