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Plastic medical bone repairing composite material

A composite material, mixing and stirring technology, applied in the field of medical biomaterials, can solve the problems of insufficient establishment of bone conduction structure, prolonged bone healing time, poor bridging, etc.

Inactive Publication Date: 2012-11-07
TIANJIN BEIYI BIOLOGICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The more important problem is that the gap left by these materials after filling or fixation can still be large or small, and the bridging ability is poor, that is, the establishment of bone conduction structure is insufficient, which ultimately prolongs the bone healing time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 1.0 g of commercially available chitosan hydrochloride, slowly pour it into 100 ml of collagen solution with a concentration of 5.0%, and pour it while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type III collagen dissolved in 0.2% phosphoric acid. After stirring evenly, slowly pour 15.0 g of calcium chloride powder into it, stir for 1 hour, and the ambient temperature is 23°C. Adjust the pH value to 9 with 1.0mol / L sodium hydroxide solution. Part of the water was removed by suction filtration of the obtained composite material, and the weight loss on drying was 70%. 5.0 μg of commercially available bone morphogenetic protein (BMP) was added and blended. Sealed packaging, γ-ray irradiation sterilization. The mass ratio of polysaccharide to collagen is 1:5; the relationship between bone morphogenetic protein (BMP) and collagen is 1.0 μg / g; the mass ratio of collagen to inorganic calcium salt is 1:3.

Embodiment 2

[0013] Take 1.3 g of commercially available sodium alginate, slowly pour it into 100 ml of collagen solution with a concentration of 13.0%, and pour it while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type II collagen dissolved in 3.0% phosphoric acid. After stirring evenly, slowly pour 65.0 g of calcium chloride powder into it, stir for 7 hours, and the ambient temperature is 23°C. Adjust the pH value to 6 with 5.0mol / L sodium hydroxide solution. The obtained composite material was freeze-dried to remove part of the moisture, and the drying weight loss was 20%, and 0.4 μg of commercially available bone morphogenetic protein (BMP) was added and pounded to homogenize. Sealed packaging, γ-ray irradiation sterilization. The mass ratio of polysaccharide to collagen is 1:10; the relationship between bone morphogenetic protein (BMP) and collagen is 0.03 μg / g; the mass ratio of collagen to inorganic calcium salt is 1:5.

Embodiment 3

[0015] Take 1.5 g of commercially available carboxylated chitosan, slowly pour it into 100 ml of collagen solution with a concentration of 1.0%, and pour it while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type III collagen dissolved in 0.2% hydrochloric acid. After stirring evenly, slowly pour in 2.0 g of calcium phosphate powder, and stir for 12 hours at an ambient temperature of 38°C. Adjust the pH value to 9 with 1.0mol / L sodium hydroxide solution. Part of the moisture was removed by suction filtration of the obtained composite material, and the loss on drying was 40%, and 0.2 μg of commercially available bone morphogenetic protein (BMP) was added, and the mixture was blended. Sealed packaging, γ-ray irradiation sterilization. The mass ratio of polysaccharide to collagen is 3:2; the relationship between bone morphogenetic protein (BMP) and collagen is 0.2 μg / g; the mass ratio of collagen to inorganic calcium salt is 1:2.

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PUM

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Abstract

The invention describes a plastic bone repairing composite material for bone filling and repairing in clinic and a preparation method thereof, belongs to the field of medical biomaterials, and mainly solves the problem that present bone repairing materials used in clinic have fixed shapes and are not easy to mould freely. In addition, through the addition of osteoinductive bone morphogenetic protein and transforming growth factor, the purpose of further accelerating bone healing is achieved. By the adoption of the method, the material is prepared by blending, stirring and free combination of polysaccharide, a collagen solution and inorganic calcium salt at a certain ambient temperature and adjustment of pH value within a certain range, and is a stable plastic viscous clay-shaped filler. The material provided by the invention is helpful for complete filling of bone defect sits and has an effect of enhancing bone forming.

Description

technical field [0001] The invention relates to a composite material of polysaccharide, collagen and inorganic calcium salt and a preparation method thereof. This material is moldable, viscous, and has a clay-like appearance and feel. For bone filling and repair. It belongs to the field of medical biomaterials. Background technique [0002] At present, there are many orthopedic medical materials, including supporting metal medical devices, and various medical composite materials with good biocompatibility and degradability, such as allogeneic bone, heterogeneous bone, collagen-based bone repair materials, bone repair ceramics, silicon-based Bone repair materials, polymer-based bone repair materials. The purpose is to reduce the distance between the broken ends of the bone, provide a good bone support, enhance bone conduction, and help accelerate the healing of bone injuries. However, most of these materials are solid and have a regular appearance, which requires the doct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/24A61L27/20A61L27/12A61L27/02A61L27/54A61L27/50
Inventor 张春红王宗龙万力
Owner TIANJIN BEIYI BIOLOGICAL PRODS
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