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Poria peel extract and application of poria peel extract in medicine for treating chronic renal failure

A technology of poria cocos cortex and extract, applied in the field of poria cocos cocos cortex ethyl acetate extract, can solve the problems of large side effects, high recurrence rate, and large toxic and side effects

Inactive Publication Date: 2012-11-14
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These therapies can improve clinical symptoms, relieve patients' pain, and improve their quality of life, but there are still many insurmountable problems: for example, medical therapy is still difficult to completely block the pathological progress, and the side effects are large; dialysis can only solve part of the kidney. Metabolic problems, the endocrine function of the kidneys cannot be improved; the kidney source for kidney transplantation is limited, and the phenomenon of immune rejection is still difficult to solve for a while
Although western medicine has a certain curative effect, it has the disadvantages of high toxicity and high recurrence rate. For example, Essite is effective in the early stage, but it will aggravate the condition in the later stage, and the blood creatinine and blood urea nitrogen remain high. eventually develop into uremia

Method used

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  • Poria peel extract and application of poria peel extract in medicine for treating chronic renal failure
  • Poria peel extract and application of poria peel extract in medicine for treating chronic renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of Poria Cortex Extract and Poria Cortex Ethyl Acetate Extract

[0017] At present, the methods of extracting medicinal materials include ultrasonic extraction, heating reflux, Soxhlet extraction, percolation and so on. The inventor adopts a simple and rapid ultrasonic extraction method to investigate the Poria cocos skin after drying and crushing, soaking with 8-10 times the volume of 95% ethanol for about 24 hours, ultrasonic time (15 minutes, 30 minutes, 45 minutes) and ultrasonic times ( 2 times and 3 times) on the extraction rate (extracted extract / crude drug amount). The results showed that under the premise of ultrasonic extraction twice, the extraction rates were 3.2%, 4.5%, and 5.2% when the ultrasonic time was 15 minutes, 30 minutes, and 45 minutes; Minutes, 30 minutes, and 45 minutes, the extraction rates were 4.8%, 6.2%, and 6.3%, respectively. The condition of final ultrasonic extraction is: ultrasonic extraction 3 times, 30 minutes...

Embodiment 2

[0019] In order to verify the effect of Poria cocos cortex ethyl acetate extract on the treatment of chronic renal failure, the applicant used the adenine-induced chronic renal failure rat model to conduct pharmacodynamic tests. The various test conditions are as follows:

[0020] 1. Experimental drug

[0021] The Poria cortex ethyl acetate extract suspension prepared in Example 1 was prepared with tap water containing 2% gum arabic powder.

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Abstract

The invention discloses a poria peel extract, which is prepared by the following preparation methods: after drying and grinding poria peels, soaking and extracting by 5-10 times of volume of 70-96% ethanol, recovering the ethanol, and condensing the ethanol to obtain a brown cream; dissolving the brown cream by distilled water, extracting liquid by ethyl acetate, and condensing ethyl acetate extract to obtain a cream. The poria peel extract provided by the invention is capable of being utilized to prepare a medicine for treating chronic renal failure.

Description

technical field [0001] The invention relates to an extract of poria cocos cortex and its application in medicine for treating chronic renal failure. The extract is an ethyl acetate extract of poria cocos cortex and belongs to the technical field of medicine. Background technique [0002] The treatment of chronic renal failure has always been a difficult problem in the medical field. According to statistics from the International Society of Nephrology, the annual incidence of chronic renal failure in natural populations is 98-198 / 1 million, and the incidence is higher in economically developed countries. The incidence rates in the United States and Japan are 802 / 1 million and 996 / 1 million, respectively. . In Western countries, renal failure is mainly secondary. It has been recognized that diabetes and hypertension are the two leading factors. At least 40% of diabetic patients have kidney disease, and about 50% of hypertensive patients have kidney disease. The number of pat...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61P13/12
Inventor 赵英永林瑞超程显隆魏锋
Owner NORTHWEST UNIV
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