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Active oxygen disinfection system and use thereof

A surfactant, singlet oxygen technology, applied in the direction of disinfection, photoactivated composition, cleaning method and utensils, etc.

Inactive Publication Date: 2012-11-21
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one disadvantage of this lens care system is that before the contact lens can be comfortably inserted into the patient's eye, the hydrogen peroxide in the solution containing the contact lens must be substantially decomposed or removed by other means, such as serial dilution or extraction

Method used

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  • Active oxygen disinfection system and use thereof
  • Active oxygen disinfection system and use thereof
  • Active oxygen disinfection system and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Pseudomonas aeruginosa (9027) was obtained from ATCC and reconstituted in nutrient medium according to ATCC recommendations before freezing in 10% glycerol solution. Pseudomonas aeruginosa were grown in nutrient broth for approximately 18 hours to enter the logarithmic phase of the bacteria, then spun down by centrifugation and the pellet resuspended in sterile phosphate buffered saline (PBS). The bacterial suspension was then diluted to obtain an OD of 0.9 at 540nm. The bacterial stock solution was then diluted 1:500 to obtain 5 -10 6 cfu / ml of the test solution.

[0080] Five photosensitizers were used: tetrakis(N-methyl-4-pyridyl)porphine tetramethylsylate (TMPyP) from Aldrich (Poole, Dorset, England), methylene blue (MB), toluidine blue O (TBO) and Rose Bengal (RB), and meso-tetrakis(4-sulfonatephenyl)porphine dihydrochloride (TSPP) were obtained from Frontier Scientific (Logan, Utah, U.S.A.). Solutions of one of the five photosensitizers were prepared at twice ...

Embodiment 2

[0095] Prepare the bacterial stock solution (Pseudomonas aeruginosa) according to the method described in Example 1, and then dilute it 1:500 to obtain a solution containing about 10 5 -10 6 cfu / ml of the test solution. Sensitizer solutions (TMPyP, MB and TBO) were prepared according to the method described in Example 1. Test solutions and control solutions were prepared according to the method described in Example 1. All solutions were then incubated for approximately 5 min at 37 °C in the dark in an orbital incubator before exposure to relevant light conditions.

[0096] Two light sources were used to evaluate the antibacterial activity of the series of photosensitizers. One is a broadband light source that emits light across the visible spectrum. This light source generates heat, so a fan is used to control the solution temperature when performing kill rate experiments. Another light source used was a red LED emitting light of a single wavelength at 630 nm. The light ...

Embodiment 3

[0109] This example illustrates the determination of absorption of photosensitizers by contact lenses. All photosensitizers were tested at a concentration of 10 μg / mL. Five lenses were tested for each photosensitizer. Experiments were performed by dipping the lenses in a photosensitizer solution and allowing them to sit overnight. Use medical tissue (medical tissue) to remove any excess liquid on the surface of the lens and record any visible color changes of the lens. The lenses were also evaluated using UV spectrometry to quantify any absorption, with blank lenses used to provide a spectral baseline. The results are shown in Table 3.

[0110] table 3

[0111]

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Abstract

The present invention provides a lens care kit for disinfecting and / or cleaning contact lenses. The lens care kit of the invention comprising: (1) a lens care solution; (2) a lens case for holding the lens care solution and a contact lens immersed in the lens care solution; (3) a singlet oxygen-generating agent which is dissolved or dispersed in a lens care solution; and (4) a light irradiation source for irradiating the singlet oxygen-generating agent for a period of time sufficient to produce a sufficient amount of singlet oxygen in the lens care solution to disinfect the contact lens.

Description

[0001] Generally, the present invention relates to methods, solutions and kits useful for cleaning and disinfecting contact lenses. Background technique [0002] Contact lenses provide vision correction tools for many consumers. There are many advantages to wearing contact lenses. Increased convenience and improved appearance are probably the two most important advantages for most consumers compared to rimmed glasses. However, contact lenses require a strict care regimen to ensure comfort and avoid eye infections. Proper care of contact lenses generally requires the consumer to regularly clean and disinfect the lenses; thereby preventing infection or other deleterious effects on ocular health that may be associated with wearing contact lenses. [0003] A currently commercially available lens care system uses an all-purpose solution to clean, disinfect and rinse contact lenses without mechanically wiping the lenses. These new "multipurpose" systems currently dominate the len...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L12/00B08B3/10
CPCC11D3/0078A61L12/06C11D3/0063C11D11/007A61L12/08
Inventor L·C·温特顿
Owner NOVARTIS AG
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