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Preparation method of magnetically targeted localization magnetic drug carrier

A magnetic targeting and drug technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of large toxic and side effects, easy agglomeration, poor magnetic targeting ability and stability, etc. Achieve the effect of good saturation magnetization and high coercivity

Active Publication Date: 2012-12-12
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a method for preparing a magnetic drug carrier for magnetic targeting and positioning, which is a method for preparing an iron-filled carbon nanotube-nanometer hydroxyapatite in-situ composite magnetic targeting and positioning magnetic drug carrier , which overcomes the disadvantages of existing magnetic drug carriers, such as large toxic and side effects, easy aggregation and introduction of pollutants during the preparation process, limited drug loading, poor magnetic targeting ability and stability, and improves the magnetic targeting drug delivery system in the field of drug delivery. In vivo application effect in cancer patients

Method used

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  • Preparation method of magnetically targeted localization magnetic drug carrier
  • Preparation method of magnetically targeted localization magnetic drug carrier
  • Preparation method of magnetically targeted localization magnetic drug carrier

Examples

Experimental program
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Effect test

Embodiment 1

[0043] The first step, preparation of iron-nanometer hydroxyapatite catalyst

[0044] According to the ratio of ferric nitrate nonahydrate: hydroxyapatite=0.03:1 by mass ratio, after weighing the required amount of ferric nitrate nonahydrate and the hydroxyapatite particles of 30nm and mixing, adopt a planetary ball mill with 1000r / min Speed ​​ball milling for 2 hours to uniformly mix ferric nitrate nonahydrate and nano-hydroxyapatite, place the mixture in a quartz ark, then place the quartz ark in a box-type resistance furnace, and then raise the temperature of the box-type resistance furnace to 300 ℃, calcined for 2 hours, and then cooled to room temperature with the furnace to obtain the iron oxide-nanometer hydroxyapatite mixture. The quartz ark containing the mixture was placed in the constant temperature zone of the horizontal tube furnace, and the Pass hydrogen into the furnace, raise the temperature to 600°C and keep it for 2 hours to reduce the iron oxide-nano-hydroxy...

Embodiment 2

[0059] The first step, preparation of iron-nanometer hydroxyapatite catalyst

[0060] According to the ratio of ferric nitrate nonahydrate: hydroxyapatite=0.76:1 by mass ratio, after weighing the required amount of ferric nitrate nonahydrate and the hydroxyapatite particles of 50nm and mixing, adopt planetary ball mill with 1200r / min Speed ​​ball milling for 4 hours to uniformly mix ferric nitrate nonahydrate and nano-hydroxyapatite, place the mixture in a quartz ark, then place the quartz ark in a box-type resistance furnace, and then raise the temperature of the box-type resistance furnace to 400 ℃, calcined for 3 hours, and then cooled to room temperature with the furnace to obtain a mixture of iron oxide-nanometer hydroxyapatite. The quartz ark containing the mixture was placed in the constant temperature zone of the horizontal tube furnace, and the Pass hydrogen into the furnace, raise the temperature to 700°C and keep it for 3 hours to reduce the iron oxide-nanometer hyd...

Embodiment 3

[0070] The first step, preparation of iron-nanometer hydroxyapatite catalyst

[0071]Ferric nitrate nonahydrate by mass ratio: the ratio of hydroxyapatite=0.4:1, after weighing the required amount of ferric nitrate nonahydrate and the hydroxyapatite particle of 40nm and mixing, adopt planetary ball mill with 1100r / min Speed ​​ball milling for 3 hours to uniformly mix ferric nitrate nonahydrate and nano-hydroxyapatite, place the mixture in a quartz ark, then place the quartz ark in a box-type resistance furnace, and then raise the temperature of the box-type resistance furnace to 350 ℃, calcined for 2.5h, and then cooled to room temperature with the furnace to obtain the iron oxide-nanometer hydroxyapatite mixture. Hydrogen gas was introduced into the tube furnace, the temperature was raised to 650°C and kept for 2.5 hours to reduce the iron oxide-nanometer hydroxyapatite mixture, and then the tube furnace was cooled to room temperature under a hydrogen atmosphere at a flow rat...

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Abstract

The invention discloses a preparation method of a magnetically targeted localization magnetic drug carrier, relates to a medicinal preparation with a carrier as characteristic, and particularly relates to a preparation method of a ferrum-filled carbon nanometer tube-nanometer hydroxyapatite in-situ composite magnetically targeted localization magnetic drug carrier. The preparation method comprises the following steps: preparing a ferrum-nanometer hydroxyapatite catalyst; preparing ferrum-filled carbon nanometer tube-nanometer hydroxyapatite in-situ composite powder; preparing purified ferrum-filled carbon nanometer tube-nanometer hydroxyapatite in-situ composite powder; preparing ferrum-filled carbon nanometer tube-nanometer hydroxyapatite in-situ composite magnetic drug carrier powder having covalent functionalization; and preparing ferrum-filled carbon nanometer tube-nanometer hydroxyapatite magnetic drug carrier modified by folic acid and chitosan. With the adoption of the preparation method, the defects such as big toxic and side effects, easy agglomeration and introduction of pollutant during preparation process, limited drug loading capacity, poor ability of magnetically targeted localization and poor stability of the existing magnetic drug carrier are overcome, and the application effect of a magnetically targeted drug delivery system in a tumor patient is improved.

Description

technical field [0001] The technical solution of the invention relates to a medical preparation characterized by a carrier, in particular to a preparation method of a magnetic drug carrier for magnetic targeting and positioning. Background technique [0002] Compared with conventional chemotherapy, magnetic-targeted chemotherapy has the characteristics of less adverse reactions, accurate guidance, and strong targeting, so it has become an effective means in the process of tumor interventional chemotherapy. In the process of magnetic-targeted chemotherapy for the treatment of malignant tumors, the magnetic-targeted drug delivery system used is mainly composed of a magnetic drug carrier (skeleton) composed of magnetic materials and chemotherapy drugs. [0003] The development of new magnetic drug carriers to improve the efficacy of magnetically targeted drug delivery systems has become one of the hotspots in the field of biomedical materials research in recent years. Studies ...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/22A61K47/04A61K47/02A61P35/00
Inventor 李海鹏梁春永王洪水张娜范佳薇王雪霞
Owner HEBEI UNIV OF TECH
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