Compound sulfamethoxazole dry suspension and preparation method thereof

Abstract

The invention discloses a compound sulfamethoxazole dry suspension and a preparation method thereof. The compound sulfamethoxazole dry suspension comprises: by weight, 750 to 850 parts of sulfamethoxazole, 150 to 170 parts of trimethoprim, 50 to 200 parts of PEG 6000, 13 to 18 parts of sodium lauryl sulfate, 50 to 200 parts of sugar powder, 10 to 15 parts of xanthan gum, 4 to 6 parts of acesulfame potassium, 13 to 18 parts of aspartame, 8 to 12 parts of sodium glutamate, 10 to 60 parts of croscarmellose sodium, 8 to 12 parts of citric acid, 2 to 10 parts of peppermint oil, 14 to 16 parts of aerosol, 5 to 20 parts of orange essence powder, and an appropriate amount of ethanol having a concentration of 75%. The compound sulfamethoxazole dry suspension has the advantages that peppermint oil produces an effect of paralysis of taste buds; sodium glutamate can shorten bitter taste retention time so that patient compliance is good; and PEG 6000 as a wetting agent prevents gelatination and does not influence a taste so that a patient can take the compound sulfamethoxazole dry suspension successfully.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound sulfamethoxazole dry suspension and a preparation method thereof. Background technique [0002] Dry suspension is a new dosage form of fine particles developed on the basis of suspension (Suspension), which is stored in solid form and taken orally in the form of suspension. The dry suspension has uniform particle distribution, good stability, fast absorption and high bioavailability. After oral administration of the dry suspension with water, it forms a suspension solution similar to syrup, which has a good taste and is willing to be taken by patients. It is not only suitable for adults, but also especially suitable for infants, children, the elderly and those with dysphagia. Therefore, dry suspension is a promising dosage form worthy of research and development. [0003] At present, the particle size of the dry suspension on the market in my country is about 0.5mm. Generally...

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Problems solved by technology

[0003] At present, the particle size of the dry suspension on the market in my country is about 0.5mm. Generally, its components are mainly composed of active ingredients, flavoring agents, preservatives, wetting agents, suspending agents, etc., but drug researchers have always It is considered that these preparations are only medicines, and the mouthfeel and the convenience of taking are placed in a secondary position, so they are very bitter or inconvenient to take when taking, which affects the compliance of patients taking. The present invention realizes two concepts, one is to select an appropriate corrective medicine. Flavoring formulations improve the taste of the drug, and the second is to choose an appropriate wetting agent to change the situation that commercially available products are generally difficult to take after adding water, so as to improve patients' compliance with the preparation

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