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Method for extracting hawthorn flavone by using pressurized liquid extraction (APLE) technique

A technology of hawthorn flavonoids and pressurized solvent is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., to achieve the effects of short extraction time, stable reaction and high yield of flavonoids

Inactive Publication Date: 2012-12-19
HEBEI NORMAL UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the advantages of less solvent consumption, simple operation, short time and high extraction efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Take the mature hawthorn fruit, remove the core, dry at low temperature, the drying temperature is 15 ℃ - 25 ℃, crush it with a pulverizer, put it into a sealed bag, and put it in a desiccator for later use;

[0015] 2. Accurately weigh 25 g of hawthorn powder and 20 g of diatomaceous earth, mix evenly, put it into a 100mL extraction pool, seal the extraction pool, place the extraction pool and collection bottle in the corresponding position of the extraction instrument, and insert 50% ethanol;

[0016] 3. Open the nitrogen valve, adjust the partial pressure of nitrogen to 0.8 MPa, turn on the power of the extractor, perform a self-inspection of the instrument, clean the pipeline of the extractor with 50% ethanol after the self-inspection is completed, and set the preheating temperature to 50 ℃ to start preheating;

[0017] 4. After step 3 is completed, set the extraction conditions: extraction temperature 50 ℃, extraction time 4 min, extraction pressure: 10 MPa, cycl...

Embodiment 2

[0019] 1, also adopt the step 1 of embodiment 1 to process standby;

[0020] 2. Accurately weigh 20 g of hawthorn powder and 20 g of diatomaceous earth, mix them evenly, put them into a 100mL extraction tank, add 5 g of diatomaceous earth to fill the gap, seal the extraction tank, put the extraction tank and the collection bottle on the opposite side of the extraction instrument position, access to methanol;

[0021] 3. Open the nitrogen valve, adjust the partial pressure of nitrogen to 0.8 MPa, turn on the power of the extractor, perform self-inspection of the instrument, clean the pipeline of the extractor with methanol after the self-inspection is completed, and set the preheating temperature to 60 ℃ to start preheating;

[0022] 4. After step 3 is completed, set the extraction conditions: extraction temperature 60 ℃, extraction time 8 min, extraction pressure: 10 MPa, cycle times: 2, rinse volume 60%, nitrogen blowing time 60 s, after the extraction is completed, hawthorn ...

Embodiment 3

[0024] 1, also adopt the step 1 of embodiment 1 to process standby;

[0025] 2. Take 30 g of the above-mentioned dried hawthorn powder and 15 g of diatomaceous earth, mix them evenly, put them into the extraction tank, then add 5 g of diatomaceous earth to fill the extraction tank, connect the nitrogen device and the extraction instrument, and extract The pool and collection bottle are placed in the corresponding position of the extractor, and connected to 70% ethanol;

[0026] 3. Open the nitrogen valve, adjust the partial pressure of nitrogen to 0.8 MPa, turn on the power of the extractor, and perform self-inspection of the instrument. After the self-inspection is completed, clean the pipeline of the extractor with 70% ethanol, and set the preheating temperature to 70 ℃ to start preheating;

[0027] 4. After step 3 is completed, set the extraction conditions: extraction temperature 70 ℃, extraction time 12 min, extraction pressure: 10 MPa, number of cycles: 3, rinsing volume...

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Abstract

The invention discloses a method for extracting flavone component in hawthorn by using a pressurized liquid extraction (APLE) technique. The method comprises removing kernels from matured hawthorn fruits, conducting low-temperature drying, smashing by using a grinder, screening hawthorn powder with needed particle size, placing for reserving, weighting certain amount of the hawthorn powder to be sufficiently mixed with certain amount of kieselguhr, filling in an extraction pool, sealing the extraction pool, placing in a pressurized solvent extraction device, adding solvent, setting parameters and then automatically extracting. Maximum 12 samples can be automatically extracted by using a same method. The pressurized liquid extraction method is adopted, extracting time is short, conditions are mild, the solvent is saved, and flavone yield is high. The method further has the advantages of simple operation, good continuity and the like. Obtained hawthorn flavone can be used for further research and development of medical treatment, health care and functional foods.

Description

technical field [0001] The invention belongs to natural product extraction technology, in particular to a process for extracting flavonoids in hawthorn by means of pressurized solvent extraction (APLE). Background technique [0002] Raw material Hawthorn fruit, Rosaceae Hawthorn genus, can be used for both medicine and food, and is rich in resources in our country. "Compendium of Materia Medica" records that this product is "sour, sweet and slightly warm, digests food accumulation, and nourishes the spleen". Hawthorn is warm in nature, sour in taste, and has the effects of digesting food accumulation, promoting blood circulation and removing blood stasis. Clinically, its dried fruit is mainly used for food accumulation, women's postpartum stasis and abdominal pain, hernia, and children's acne. The research on the chemical components of hawthorn began in 1921, and the research before the 1950s mostly focused on the cellulose, tannins, triterpenoids and other components conta...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P9/00A61K131/00
Inventor 杨越冬王同坤杜彬曹会凯
Owner HEBEI NORMAL UNIVERSITY OF SCIENCE AND TECHNOLOGY
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