Nano-hydrogel with micro electric field response function and preparation method and application thereof
A nano-hydrogel and micro-electric field technology, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulations, aerosol delivery, etc., can solve problems that do not involve the evaluation of nano-hydrogel electric field response performance, and achieve drug Accelerated release speed, mild reaction conditions, and good dispersion stability
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Embodiment 1
[0046] Accurately weigh 8.5g of DMAEMA, 0.5g of ST and 0.5g of NaSS into a 250mL four-necked round bottom flask, and add 70ml of water. Accurately weigh 0.5 g of the cross-linking agent N, N-methylenebisacrylamide, add 10 ml of water, dissolve it ultrasonically in a water bath, and add it to the above-mentioned flask. At room temperature, turn on the stirring switch with a rotation speed of 150rpm / min. At the same time, nitrogen gas is introduced into the reaction bottle. After 1 hour, an aqueous solution of initiator (potassium persulfate and sodium metabisulfite dissolved in 10 mL of distilled water) is added to initiate the reaction, and nitrogen gas is continuously introduced to react for 24 hours. . After the reaction, the reaction solution was dialyzed for 48 hours with a dialysis bag with a molecular weight of 8-14K Dalton. The dialysate was freeze-dried for 24 hours to obtain a solid nano-hydrogel product.
[0047]The particle diameter of the nano hydrogel is deter...
Embodiment 2
[0049] Accurately weigh 8.5g of DMAEMA and 1.0g of ST into a 250mL four-neck round bottom flask, and add 70ml of water. Accurately weigh 0.5 g of the cross-linking agent N, N-methylenebisacrylamide, add 10 ml of water, dissolve it ultrasonically in a water bath, and add it to the above-mentioned flask. At room temperature, turn on the stirring switch, the rotation speed is 150rpm / min, and at the same time, nitrogen gas is introduced into the reaction bottle. After 1h, an aqueous solution of initiator (potassium persulfate and sodium metabisulfite dissolved in 10mL of distilled water) is added to initiate the reaction, and nitrogen gas is continuously introduced to react for 30h. . After the reaction, the reaction solution was dialyzed for 40 hours with a dialysis bag with a molecular weight of 8-14K Dalton. The dialysate was freeze-dried for 20 hours to obtain a solid nano-hydrogel product.
[0050] The particle size of the nano hydrogel is determined to be 150.2nm, and th...
Embodiment 3
[0052] Accurately weigh 8.5g of DMAEMA and 1.0g of NaSS into a 250mL four-neck round bottom flask, and add 70ml of water. Accurately weigh 0.5 g of the cross-linking agent N, N-methylenebisacrylamide, add 10 ml of water, dissolve it ultrasonically in a water bath, and add it to the above-mentioned flask. At room temperature, turn on the stirring switch with a rotation speed of 150rpm / min. At the same time, nitrogen gas is introduced into the reaction bottle. After 2 hours, an aqueous initiator solution (potassium persulfate and sodium metabisulfite dissolved in 10 mL of distilled water) is added to initiate the reaction, and nitrogen gas is continuously introduced to react for 24 hours. . After the reaction, the reaction solution was dialyzed for 40 hours with a dialysis bag with a molecular weight of 8-14K Dalton. The dialysate was freeze-dried for 30 hours to obtain a solid nano-hydrogel product.
[0053] The particle size of the nano-hydrogel is determined to be 122.2nm...
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