Synthesis method for acrylpimaric acid base dithiadiazole derivative

A technology of propylene pimaric acid base and bisthiadiazole, which is applied in organic chemistry and other fields, can solve problems that have not been reported at home and abroad, and achieve the effects of expanding use, increasing added value, and increasing fat solubility
CN102875487AInactive Publication Date: 2013-01-16GUANGXI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGXI UNIV
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthesis method for an acrylpimaric acid base dithiadiazole derivative. The synthesis method comprises the following steps of: reacting acrylpimaric acid serving as a raw material with thionyl chloride to prepare acrylpimaric acid diacryl chloride; reacting thiosemicarbazide with various substituted benzoic acids under the action of POCl3 to prepare a 2-amino-5-substituted phenyl-1, 3, 4-thiadiazole compound; and then performing N-acylation reaction with the acrylpimaric acid diacryl chloride to synthesize the acrylpimaric acid base dithiadiazole compound. According to the synthesis method, a thiadiazole group with various bioactivities is introduced into the acrylpimaric acid structure, so that the application range of the acrylpimaric acid is expanded. The used acrylpimaric acid is a modified product of natural product rosin; and the preparation method is simple and the cost is low.
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Description

technical field

[0001] The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing acrylpimaric acid-based bisthiadiazole derivatives. Background technique

[0002] Thiadiazole compounds have been applied in the fields of medicine and pesticides due to their wide range of biological activities. The industrialized products that have been prepared in medicine include methazolamide for the treatment of cerebral edema, cardiac edema and glaucoma, diuretic sulfonamide and acetazolamide, etc. In the field of pesticides, we have produced the herbicide thiamidazolone, etc., the fungicide Yeqingshuang for the prevention and treatment of rice bacterial blight, the fluthiacetmethy developed by Novartis and the fluthiamide developed by Bayer, etc., and the insecticide acithiazole for the prevention and control of sanitary pests, etc. . Thiadiazole is an important active heterocyclic group. Because of its low toxicity to human body and ...

Claims

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