Preparation method and application of morelberry effective fractions

A technology of effective parts and physalis, applied in the application of hypoglycemic drugs, the field of preparation of effective part groups, can solve the problems of the application of hypoglycemic drugs for the preparation method of separation of effective part groups that have not been disclosed publicly, and achieve low production cost and high efficacy Exact and easy preparation process

Active Publication Date: 2013-01-23
五源本草(山东)健康科技有限公司
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Problems solved by technology

[0006] The above-mentioned documents and patents, etc., have not yet disclosed the preparation method of

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  • Preparation method and application of morelberry effective fractions

Examples

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Example Embodiment

[0029] Example 1: Preparation of physalis effective part group

[0030] Put 20 kg of physalis in an extraction tank, add 15 times the amount of 80% ethanol, extract twice, 1 hour each time, combine the extracts, recover the ethanol, filter, and concentrate to a liquid medicine with a relative density of 1.10 (60°C); Extract three times with dichloromethane, the amount of each time is the same as the amount of the drug solution, combine the dichloromethane extracts, recover the solvent to dryness, and apply to the polyamide column, eluting with 30% ethanol for 3BV, 60% ethanol for eluting 3BV, and combined elution The solution was concentrated and dried to obtain 0.62kg of total terpenoid effective fractions; the remaining aqueous solution after dichloromethane extraction was evaporated off the solvent, and passed through the LSA-21 macroporous adsorption resin column, eluted with water 3 times the volume of the resin column (3BV), Then use 30% ethanol to elute 3BV and 70% ethanol...

Example Embodiment

[0031] Example 2: Preparation of physalis effective part group

[0032] Put 20kg of physalis calyx in an extraction tank, add 20 times the amount of 30% ethanol, extract 3 times, 2 hours each time, combine the extracts, recover the ethanol, filter, and concentrate to a relative density of 1.0 (60°C). Medicine solution; extract three times with ethyl acetate, the amount of each time is the same as the amount of the drug solution, combine the ethyl acetate extracts, recover the solvent to dryness, and put on a polyamide column, eluting 3BV with 10% ethanol, and eluting 3BV with 80% ethanol , Combine the eluates, concentrate and dry to obtain 0.52kg of total terpenoid effective parts; evaporate the remaining aqueous solution after ethyl acetate extraction, pass the NKA macroporous adsorption resin column, eluting 3 times the volume of the resin column with water (3BV ), then use 20% ethanol to elute 3BV, 90% ethanol to elute 2BV, combine the alcohol eluates, concentrate and dry to o...

Example Embodiment

[0033] Example 3: Preparation of physalis effective part group

[0034] Put 10kg of physalis root, physalis stem and physalis leaf mixture in an extraction tank, add 10 times the amount of water, extract 3 times, each 1.5 hours, combine the extracts, filter, and concentrate to a relative density of 1.20 (60℃ ) Liquid; extract three times with cyclohexane, the amount of each time is the same as the amount of the liquid, combine the cyclohexane extracts, recover the solvent to dryness, apply to the polyamide column, elute 3BV with 20% ethanol, and wash with 90% ethanol Remove 3BV, combine the eluates, concentrate and dry to obtain 0.24kg of total terpenoid effective parts; evaporate the remaining aqueous solution after cyclohexane extraction, pass through an ADS-17 macroporous adsorption resin column, and elute 3 times the amount of resin with water Column volume (3BV), then use 30% ethanol to elute 3BV, 70% ethanol to elute 2BV, 95% ethanol to elute 2BV, combine the alcohol eluate...

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Abstract

The invention relates to a preparation method and an application of morelberry effective fractions. The preparation method comprises the following steps of: extracting morelberry; performing chromatography purification techniques through polyamide, macroporous resins, ion exchange resins and the like to obtain a total steroid effective fraction, a general flavone effective fraction and a total organic acid effective fraction; and combining and uniformly mixing one or two or three of three effective fraction extracts to obtain the morelberry effective fractions. A morelberry effective fraction extract disclosed by the invention can be combined with pharmaceutically-acceptable carriers or other proper excipients, is prepared into an oral administration dosage form or a non-oral administration injection or other dosage forms according to the conventional method, and can be applied to preparation of a medicament for preventing and treating diabetes mellitus.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method and application of effective fractions of Chinese medicinal materials, in particular to a preparation method of effective fractions of physalis and its application in hypoglycemic drugs. Background technique [0002] With the aging of the world's population, diabetes has become a common and frequently-occurring disease, and its incidence is on the rise in industrialized countries. According to statistics, there are about 150 million diabetic patients in the world, 80% of which are non-insulin-dependent diabetes (type 2), of which there are about 30 million in my country. The number of deaths caused by diabetes complications ranks third after cardiovascular and cerebrovascular diseases and cancer in developed countries, which has attracted great attention from all over the world, and researches on the pathogenesis and drug prevention and ...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P3/10
Inventor 孔倩倩
Owner 五源本草(山东)健康科技有限公司
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