Qingwen Baidu San solid dispersion and preparation method thereof

A technology of solid dispersion, Qingwen Baidu Powder, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, aluminum/calcium/magnesium active ingredients, etc., to increase solubility, improve bioavailability, increase dispersion and The effect of specific surface area

Active Publication Date: 2013-01-23
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]The amount of carrier used in the preparation of solid dispersion is relatively large, and the percentage of drug is not high, so it is still difficult to apply to larger doses of drugs
Traditional Chinese medicine prescriptions often have large doses, which greatly restricts the application of solid dispersion technology in the field of traditional Chinese medicine. It is urgent to have a new type of carrier that has a large drug load and can promote the stability of solid dispersions.

Method used

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  • Qingwen Baidu San solid dispersion and preparation method thereof
  • Qingwen Baidu San solid dispersion and preparation method thereof
  • Qingwen Baidu San solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Qingwenbaidu powder solid dispersion, the raw materials used and their mass percentages are:

[0043] Gypsum 15%

[0044] Rehmannia glutinosa 3.75%

[0045] Buffalo Horn 7.5%

[0046] Coptis 2.5%

[0047] Gardenia 3.75%

[0048] Moutan Bark 2.5%

[0049] Skullcap 3.13%

[0050] Paeoniae Rubra 3.13%

[0051] Scrophulariaceae 3.13%

[0052] Anemarrhena 3.75%

[0053] Forsythia 3.75%

[0054] Bellflower 3.13%

[0055] Licorice 1.86%

[0056] Bamboo leaves 3.12%

[0057] Polyethylene glycol 6000 22%

[0058] Poloxamer 188 12%

[0059] Glycerin 6%.

[0060] The preparation method of described Qingwenbaidu powder solid dispersion, comprises the following steps:

[0061] (1) The ingredients are taken in proportion, and the gypsum, rehmannia glutinosa, buffalo horn, coptis, gardenia, moutan bark, skullcap, red peony root, scrophulariaceae, anemarrhena, forsythia, platycodon, licorice and light bamboo leaves are crushed through a 100-mesh sieve, and mixed to obt...

Embodiment 2

[0066] Qingwenbaidu powder solid dispersion, the raw materials used and their mass percentages are:

[0067] Gypsum 15%

[0068] Rehmannia glutinosa 3.75%

[0069] Buffalo Horn 7.5%

[0070] Coptis 2.5%

[0071] Gardenia 3.75%

[0072] Moutan Bark 2.5%

[0073] Skullcap 3.13%

[0074] Paeoniae Rubra 3.13%

[0075] Scrophulariaceae 3.13%

[0076] Anemarrhena 3.75%

[0077] Forsythia 3.75%

[0078] Bellflower 3.13%

[0079] Licorice 1.86%

[0080] Bamboo leaves 3.12%

[0081] Polyethylene glycol 6000 28%

[0082] Poloxamer 188 6%

[0083] Propylene Glycol 6%.

[0084] The preparation method of described Qingwenbaidu powder solid dispersion, comprises the following steps:

[0085] (1) The ingredients are taken in proportion, and the gypsum, rehmannia glutinosa, buffalo horn, coptis, gardenia, moutan bark, skullcap, red peony root, scrophulariaceae, anemarrhena, forsythia, platycodon, licorice and light bamboo leaves are crushed through a 120 mesh sieve, and mixed ...

Embodiment 3

[0090] Qingwenbaidu powder solid dispersion, the raw materials used and their mass percentages are:

[0091] Gypsum 15%

[0092] Rehmannia glutinosa 3.75%

[0093] Buffalo Horn 7.5%

[0094] Coptis 2.5%

[0095] Gardenia 3.75%

[0096] Moutan Bark 2.5%

[0097] Skullcap 3.13%

[0098] Paeoniae Rubra 3.13%

[0099] Scrophulariaceae 3.13%

[0100] Anemarrhena 3.75%

[0101] Forsythia 3.75%

[0102] Bellflower 3.13%

[0103] Licorice 1.86%

[0104] Bamboo leaves 3.12%

[0105] Polyethylene glycol 6000 25%

[0106] Poloxamer 188 6%

[0107] Glycerin 9%.

[0108] The preparation method of described Qingwenbaidu powder solid dispersion, comprises the following steps:

[0109] (1) Take the ingredients according to the proportion, and use the superfine pulverization method to separate the gypsum, rehmannia, buffalo horn, coptis, gardenia, moutan bark, skullcap, red peony root, scrophulariaceae, anemarrhena, forsythia, bellflower, licorice and light bamboo The leaves a...

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Abstract

The invention belongs to the technical field of Chinese medicines and particularly relates to a Qingwen Baidu San solid dispersion. The Qingwen Baidu San solid dispersion comprises the following ingredients: gypsum, dried rehmannia root, buffalo horn, golden thread, gardenia, tree peony bark, baical skullcap root, red paeony root, figwort root, common anemarrhena rhizome, weeping forsythia, balloon flower root, liquorice, common lophatherum herb, polyethyleneglycol 6000, poloxamer, glycerol or propylene glycol. The Qingwen Baidu San solid dispersion is prepared by a superfine grinding technology and a solid dispersion technology; an appropriate carrier is selected, so that the leaching of active ingredients of the Qingwen Baidu San solid dispersion is facilitated; and the dispersity and specific surface area of medicines are increased, so that the solubility and dissolving-out speed of the Qingwen Baidu San solid dispersion are increased, the bioavailability of the medicines is improved, and the formulation blending, the administration and the exertion of a therapeutic effect are facilitated. The Qingwen Baidu San solid dispersion has the effects of purging fire for removing toxin, cooling blood and the like, and can be used for treating febrile diseases such as macular eruption due to heat toxin, and high fever and coma.

Description

Technical field [0001] The present invention is a Chinese medicine technology field, which involves a method of clearing the scattered solid scattered body and its preparation methods. Background technique [0002] The sculpture of the Qing Guan is a compound Chinese medicine composed of plaster, ground yellow, cattle horns, paddy horn, Huanglian, gardenia, peony peel, scutellaria baicalensis, red peony, Xuanyou, forsythia, oraoe, licorice, and light bamboo leaves.It has the effects of diarrhea and detoxification and cooling blood. It is clinically used to treat diseases such as heat poisoning spots and high fever.The routine method preparation of the clearing of the plague, the ground yellow, the horn of the cattle, the horn of the cattle, the paddy, the puppet, the peony peel, the scutellaria baicalensis, the red peony, the mothers, the forsythia, the bellflower, the licorice, and the light bamboo leaf are crushed and mixed directly.Welfare.Due to the difficulty of the effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/14A61P29/00A61P31/00A61K33/06A61K35/32
Inventor 刘钊锋唐洪峰赵建平郭芳茹吴胜耀苑青艳
Owner 河南亚卫动物药业有限公司
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