Electrochemical method for preparing hydroxyapatite dendritic micro nano composite coating on surface of metallic titanium

A hydroxyapatite, micro-nano composite technology, applied in the field of biomedical materials, can solve the problems of low solubility, slow integration rate, etc., and achieve easy adsorption, easy operation, and excellent combination effect

Inactive Publication Date: 2013-01-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, micron-sized HA has low solubility, which makes it slow to integrate with bone in the early stage, and can only play an advantage in the long-term healing process; on the contrary, nano-sized HA coatings have the same good biological properties, More excellent biodegradability and wettability

Method used

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  • Electrochemical method for preparing hydroxyapatite dendritic micro nano composite coating on surface of metallic titanium
  • Electrochemical method for preparing hydroxyapatite dendritic micro nano composite coating on surface of metallic titanium
  • Electrochemical method for preparing hydroxyapatite dendritic micro nano composite coating on surface of metallic titanium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1) Add molar concentration of 1.2mMCaCl 2 , the molar concentration is 0.72mMNH 4 h 2 PO 4 , The molar concentration is 0.1MNaCl mixed, the pH value of the electrolyte is adjusted to 6 with ammonia water or hydrochloric acid solution, heated to 85°C and then kept at a constant temperature to obtain a low-concentration Ca-P electrolyte;

[0031] 2) Add molar concentration of 9.6mMCaCl 2 , the molar concentration is 5.76mM NH 4 h 2 PO 4 , molar concentration is 0.1MNaCl, molar concentration is 38.4mM Na 3 Mix with Cit, adjust the pH value of the electrolyte to 6 with ammonia water or hydrochloric acid solution, heat to 60°C and keep the temperature to obtain a high-concentration Ca-P electrolyte;

[0032] 3) Platinum is used as the anode, and the metal titanium substrate is used as the cathode. The anode and the cathode are completely immersed in the low-concentration Ca-P electrolyte. The DC voltage between the two electrodes is set to -3.0V, and the distance betw...

Embodiment 2

[0036] 1) Add molar concentration of 0.6mMCaCl 2 , the molar concentration is 0.36mMNH 4 h 2 PO 4 , The molar concentration is 0.1MNaCl mixed, the pH value of the electrolyte is adjusted to 6 with ammonia water or hydrochloric acid solution, heated to 85°C and then kept at a constant temperature to obtain a low-concentration Ca-P electrolyte;

[0037] 2) Add molar concentration of 2.4mMCaCl 2 , the molar concentration is 1.44mM NH 4 h 2 PO 4 , molar concentration is 0.1MNaCl, molar concentration is 1.2mM Na 3 Mix with Cit, adjust the pH value of the electrolyte to 6 with ammonia water or hydrochloric acid solution, heat to 60°C and keep the temperature to obtain a high-concentration Ca-P electrolyte;

[0038] 3) Platinum is used as the anode, and the metal titanium substrate is used as the cathode. The anode and the cathode are completely immersed in the low-concentration Ca-P electrolyte. The DC voltage between the two electrodes is set to -3.0V, and the distance betwe...

Embodiment 3

[0042] 1) Add molar concentration of 0.9mMCaCl 2 , the molar concentration is 0.54mMNH 4 h 2 PO 4 , The molar concentration is 0.1MNaCl mixed, the pH value of the electrolyte is adjusted to 6 with ammonia water or hydrochloric acid solution, heated to 85°C and then kept at a constant temperature to obtain a low-concentration Ca-P electrolyte;

[0043] 2) Add molar concentration of 6mMCaCl 2 , the molar concentration is 3.6mM NH 4 h 2 PO 4 , molar concentration is 0.1MNaCl, molar concentration is 24mM Na 3 Mix with Cit, adjust the pH value of the electrolyte to 6 with ammonia water or hydrochloric acid solution, heat to 60°C and keep the temperature to obtain a high-concentration Ca-P electrolyte;

[0044] 3) Platinum is used as the anode, and the metal titanium substrate is used as the cathode. The anode and the cathode are completely immersed in the low-concentration Ca-P electrolyte. The DC voltage between the two electrodes is set to -3.0V, and the distance between t...

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Abstract

The invention discloses an electrochemical method for preparing a hydroxyapatite dendritic micro nano composite coating on the surface of metallic titanium, comprising the following steps: preparing two electrolytes containing Ca-P with a high concentration and a low concentration, wherein Ca-P is the component element of hydroxyapatite; adding the electrolytes in a container equipped with a constant temperature heating system; by taking Pt as anode and metallic Ti as cathode, immersing the two electrodes in the electrolytes; after depositing in the Ca-P electrolyte with the low concentration, continue to deposite in the Ca-P electrolyte with the high concentration to form the hydroxyapatite dendritic micro nano composite coating on the surface of the metallic titanium matrix; taking out the matrix and cleaning the matrix to remove the electrolytes adhered on the surface, and drying in a drying box. According to the invention, the prepared coating disclosed has surface geometric externality with double dimensions from nanometer to micrometer, benefits the adhesion of osteoblast and subsequent growth by differentiation, simultaneously changes the dissolving characteristic of the coating, has good wettability, and has great application values.

Description

technical field [0001] The invention relates to an electrochemical preparation method for preparing a dendritic micro-nano composite coating on the surface of metal titanium, belonging to the field of biomedical materials. Background technique [0002] A large number of experimental reports pointed out that the different morphology of biological coating materials will have a significant impact on cell adsorption, cell morphology, biomineralization process and gene expression, especially in terms of size, nanoscale materials have more superior biological properties: Dolatshahi-Pirouz et al. found that the shed-shaped nano-metal tantalum surface is more conducive to the formation of fibronectin and eventually adsorbed cells. At the same time, compared with the flat surface, the dome-shaped and shed-shaped nano-metal tantalum surface is more conducive to the pulp Differentiation of mesenchymal stem cells; Michael et al. induced cell adsorption with a special morphology by chan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/08
Inventor 王小祥杜博
Owner ZHEJIANG UNIV
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