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Sterilization microcapsule suspending agent with adjustable releasing rate and preparation and usage method thereof

A technology of microcapsule suspension and controlled release, which is applied in the direction of microcapsule preparations, botany equipment and methods, fungicides, etc., can solve the problems of easy decomposition, achieve good slow-release performance, good permeability and quick-acting, Effect of good photolysis resistance

Inactive Publication Date: 2014-04-09
BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, it can better overcome the problem that natamycin is easy to decompose under light, and can be used to prevent fungal diseases on the surface of plants.

Method used

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  • Sterilization microcapsule suspending agent with adjustable releasing rate and preparation and usage method thereof
  • Sterilization microcapsule suspending agent with adjustable releasing rate and preparation and usage method thereof
  • Sterilization microcapsule suspending agent with adjustable releasing rate and preparation and usage method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: LBL assembles NA microcapsules and performance testing

[0053] (1) LBL assembled NA microcapsules

[0054] 1) Disperse natamycin in deionized water to prepare a suspension, and ultrasonically refine the suspension for 5-10 minutes to obtain a uniform aqueous suspension A of 30 g / L natamycin;

[0055] 2) Assemble the first layer: add sodium alginate solution, Tween-80, sodium chloride and deionized water to the suspension A obtained in step 1) under stirring, so that the content of natamycin in the reaction system is 15g / L, the content of sodium alginate is 1g / L, the content of Tween-80 is 10g / L, and the content of sodium chloride is 14.6g / L. Immediately after the addition, adjust the pH of the system to 4.5. After reacting for 15-20min, centrifuge and water Wash 3 times, and finally resuspend the precipitate in deionized water to obtain a uniform aqueous suspension A1 of natamycin microcapsules with a natamycin content of 30 g / L;

[0056] 3) Assemble the...

Embodiment 2

[0096] The preparation of embodiment 2 microcapsule suspension

[0097] The microcapsule suspension prepared in Example 1 was left to stand and discarded different amounts of supernatant to obtain NA content respectively as microcapsule suspensions of 20g / L and 60g / L, and then press the components of Table 8-9 Each component is weighed according to the mass ratio to prepare a microcapsule suspension. The method is to weigh the anti-sedimentation agent first, add an appropriate amount of water to fully dissolve it, and make it into a paste, then add the weighed microcapsule suspension, and then add other ingredients, fully stir evenly under the condition of the mixer speed of 800-1000rpm, Natamycin microcapsule suspension (NACS). Microcapsule suspensions with 4-layer assembly and 8-layer assembly were prepared respectively, code-named NACS-4 and NACS-8, respectively.

[0098] Table 8 The mass ratio of each component of natamycin microcapsule suspension (NACS-4) (1)

[0099] ...

Embodiment 3

[0102] Embodiment 3 Microcapsule drug effect test

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Abstract

The invention discloses a sterilization microcapsule suspending agent with an adjustable releasing rate and a preparation and usage method thereof. An active ingredient of core materials of a microcapsule is natamycin, sodium alginate and chitosan serve as wall materials, and the suspending agent is prepared through a layer-by-layer (LBL) method. The releasing rate of the microcapsule can be adjusted according to requirements of quick effects and persist effects for preventing plant fungal diseases, and the suspending agent has the advantages of being wide in sterilization spectrum, low in consumption, good in sterilization effect, not easy to obtain resistance and the like.

Description

technical field [0001] The invention belongs to the technical field of biopesticide processing and application, and in particular relates to a natamycin microcapsule and its suspending agent whose release rate can be controlled, as well as their preparation and use methods. Background technique [0002] Natamycin (Natamycin, NA) is a secondary metabolite of Streptomyces natalensis, Streptomyces lydicus A01 (Sotrytis lydicus) (Chinese patent: 200710187435.1), and belongs to antibiotic antifungal agents. NA has the advantages of broad spectrum, high efficiency, safety, and not easy to obtain resistance. It has been widely used in the fields of beverage, feed, food and medicine, but in agricultural production, it is limited to the control of inoculum diseases of cotton and beans. This is because the molecular structure of NA belongs to polyene macrolide, which is susceptible to ultraviolet light and photolysis in aqueous solution, thus limiting its application in the prevention...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02A01N43/90A01N25/04A01P3/00
Inventor 卢向阳刘伟成杨万吉卢彩鸽吴慧玲董丹
Owner BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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